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公开(公告)号：US09212390B2
公开(公告)日：2015-12-15
申请号：US13695427
申请日：2011-04-28
申请人： Boye Schnack Nielsen , Stine Jørgensen , Jan Skouv , Adam Baker , Søren Møller
发明人： Boye Schnack Nielsen , Stine Jørgensen , Jan Skouv , Adam Baker , Søren Møller
CPC分类号： C12Q1/6876 , C12Q1/6832 , C12Q1/6841 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , C12Q2527/125 , C12Q2525/207
摘要： An improved method of in situ hybridization which relies on an improved formulation of the in situ hybridization buffer is described. In at least some formulations the buffer are non-toxic. The combination of Locked Nucleic Acid (LNA) comprising ISH probes and the improved ISH buffer are useful for detection of small non-coding RNA as well as in the manufacturing of ISH kits directed to the detection of such small non-coding RNA. Further disclosed is a method of semi-quantitative ISH and demonstration of the semi-quantitative ISHs diagnostic potential.
摘要翻译： 描述了依赖于原位杂交缓冲液的改进制剂的改进的原位杂交方法。 在至少一些制剂中，缓冲液是无毒的。 包含ISH探针和改进的ISH缓冲液的锁定核酸（LNA）的组合可用于检测小的非编码RNA以及制造用于检测这种小的非编码RNA的ISH试剂盒。 进一步披露的是半定量ISH的方法和半定量ISHs诊断潜力的证明。
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公开(公告)号：US08207347B2
公开(公告)日：2012-06-26
申请号：US12967414
申请日：2010-12-14
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D213/82 , C07D213/89 , C07D413/06
摘要： The present invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.
摘要翻译： 本发明涉及可用于治疗，特别是治疗精神病的化合物，包含所述化合物的组合物，以及治疗包括施用所述化合物的疾病的方法。
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公开(公告)号：US20100286044A1
公开(公告)日：2010-11-11
申请号：US11795104
申请日：2006-12-29
CPC分类号： C12Q1/6881 , C12Q1/6813 , C12Q1/6827 , C12Q1/6832 , C12Q1/6841 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207 , C12Q2527/107 , C12Q2525/101
摘要： Disclosed is a method for determining the cellular or tissue origin of tumor cells. The method entails determining the presence of at least one micro RNA (miRNA) in a sample derived from tumor tissue and based on the said determination establishing a miRNA expression profile and comparing this with pre-established miRNA expression profiles from cells, tissues or tumors. The determination uses short oligonucleotide probes comprising modified affinity-enhancing nucleobases.
摘要翻译： 公开了一种确定肿瘤细胞的细胞或组织来源的方法。 该方法需要确定衍生自肿瘤组织的样品中至少一种微RNA（miRNA）的存在，并且基于所述确定miRNA表达谱并将其与来自细胞，组织或肿瘤的预先确定的miRNA表达谱进行比较。 该测定使用包含修饰的亲和力增强核碱基的短寡核苷酸探针。
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公开(公告)号：US07834008B2
公开(公告)日：2010-11-16
申请号：US10568483
申请日：2004-08-13
申请人： Jan Kehler , Tore Hansen , Anders Poulsen , Berith Bjørnholm , Thomas Ruhland , Morten Bang Nørgaard , Søren Møller Nielsen
发明人： Jan Kehler , Tore Hansen , Anders Poulsen , Berith Bjørnholm , Thomas Ruhland , Morten Bang Nørgaard , Søren Møller Nielsen
IPC分类号： A61K31/54 , A61K31/44 , C07D513/00 , C07D295/00 , C07D471/00
CPC分类号： C07D211/34 , C07D211/14 , C07D211/32 , C07D211/52 , C07D211/58 , C07D211/64 , C07D295/155 , C07D401/06 , C07D471/10
摘要： The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders.
摘要翻译： 本发明涉及式（I）的环丙基衍生物及其盐。 这些化合物是NK3受体拮抗剂，因此可用于治疗涉及NK3受体的疾病，例如， 精神障碍
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公开(公告)号：US07273745B2
公开(公告)日：2007-09-25
申请号：US11605148
申请日：2006-11-28
申请人： Lene Nonboe Andersen , Hanne Dela, legal representative , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
摘要翻译： 本发明涉及属于多糖裂解酶家族1的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）（SEQ ID NO：2的氨基酸236-242）的果胶酸裂解酶在中性的工业过程中具有良好的性能 或碱性条件如洗涤和纺织加工。 果胶裂解酶可以衍生自芽孢杆菌属物种。
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公开(公告)号：US06368843B1
公开(公告)日：2002-04-09
申请号：US09694531
申请日：2000-10-23
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N926
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
摘要翻译： 属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）的新一组果胶酸裂解酶在中性或碱性条件例如洗涤和纺织加工中在工业过程中具有良好的性能。 果胶裂解酶可以衍生自芽孢杆菌属物种。
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公开(公告)号：US06187580B1
公开(公告)日：2001-02-13
申请号：US09198955
申请日：1998-11-24
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N988
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase are derivable from Bacillus species.
摘要翻译： 属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）的新一组果胶酸裂解酶在中性或碱性条件例如洗涤和纺织加工中在工业过程中具有良好的性能。 果胶裂解酶可从芽孢杆菌属物种衍生。
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公开(公告)号：US20130164750A1
公开(公告)日：2013-06-27
申请号：US13695427
申请日：2011-04-28
申请人： Boye Schnack Nielsen , Stine Jørgensen , Jan Skouv , Adam Baker , Søren Møller
发明人： Boye Schnack Nielsen , Stine Jørgensen , Jan Skouv , Adam Baker , Søren Møller
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6832 , C12Q1/6841 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , C12Q2527/125 , C12Q2525/207
摘要： An improved method of in situ hybridization which relies on an improved formulation of the in situ hybridization buffer is described. In at least some formulations the buffer are non-toxic. The combination of Locked Nucleic Acid (LNA) comprising ISH probes and the improved ISH buffer are useful for detection of small non-coding RNA as well as in the manufacturing of ISH kits directed to the detection of such small non-coding RNA. Further disclosed is a method of semi-quantitative ISH and demonstration of the semi-quantitative ISHs diagnostic potential.
摘要翻译： 描述了依赖于原位杂交缓冲液的改进制剂的改进的原位杂交方法。 在至少一些制剂中，缓冲液是无毒的。 包含ISH探针和改进的ISH缓冲液的锁定核酸（LNA）的组合可用于检测小的非编码RNA以及制造用于检测这种小的非编码RNA的ISH试剂盒。 进一步披露的是半定量ISH的方法和半定量ISHs诊断潜力的证明。
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公开(公告)号：US08188255B2
公开(公告)日：2012-05-29
申请号：US11975644
申请日：2007-10-19
申请人： Thomas Litman , Søren Møller , Søren Morgenthaler Echwald , Morten Lindow , Anders Martin Bøgild Jacobsen , Anders Stærmose Krogh , Sanne Nygaard , Rolf Søkilde
发明人： Thomas Litman , Søren Møller , Søren Morgenthaler Echwald , Morten Lindow , Anders Martin Bøgild Jacobsen , Anders Stærmose Krogh , Sanne Nygaard , Rolf Søkilde
IPC分类号： C07H21/04
CPC分类号： C07H21/02 , C12Q1/6886
摘要： The invention provides new sequences for human microRNAs associated with cancer which may be used as molecular markers for cancer diagnostics or as therapeutic targets or agents.
摘要翻译： 本发明提供了与癌症相关的人微小RNA的新序列，其可以用作癌症诊断的分子标记或作为治疗靶标或药剂。
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公开(公告)号：US20110144164A1
公开(公告)日：2011-06-16
申请号：US12967414
申请日：2010-12-14
IPC分类号： A61K31/4412 , C07D213/82 , A61K31/4418 , C07D413/06 , A61K31/4439 , C07D213/89 , C07D213/85 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/24 , A61P3/04 , A61P29/00 , A61P11/06 , A61P11/14 , A61P13/00
CPC分类号： C07D213/82 , C07D213/89 , C07D413/06
摘要： The present invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.
摘要翻译： 本发明涉及可用于治疗，特别是治疗精神病的化合物，包含所述化合物的组合物，以及治疗包括施用所述化合物的疾病的方法。
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