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1.发明授权公开(公告)号：US08888969B2
公开(公告)日：2014-11-18
申请号：US13061465
申请日：2009-09-01
申请人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
IPC分类号： C25B11/02 , G01N27/30 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.
摘要翻译： 本文公开了纳米结构微电极和结合其的生物感测装置。
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公开(公告)号：US07741033B2
公开(公告)日：2010-06-22
申请号：US10913925
申请日：2004-08-06
CPC分类号： C12Q1/6825 , G01N27/3278 , C12Q2563/173 , C12Q2563/155 , C12Q2563/113
摘要： The detection of specific nucleic acid sequences using electrochemical readout would permit the rapid and inexpensive detection and identification of bacterial pathogens and the analysis of human genes. A new assay developed for this purpose is described that harnesses an electrocatalytic process to monitor nucleic acid hybridization. Furthermore, the new assay when used on nanoscale electrodes, provides ultrasensitive detection of nucleic acids.
摘要翻译： 使用电化学读数检测特异性核酸序列将允许快速和便宜地检测和鉴定细菌病原体并分析人类基因。 描述了为此目的开发的新的测定法，其利用电催化过程来监测核酸杂交。 此外，当用于纳米尺度电极时的新测定提供核酸的超敏感检测。
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公开(公告)号：US09173952B2
公开(公告)日：2015-11-03
申请号：US13700988
申请日：2011-05-27
申请人： Shana Kelley , Mark Pereira
发明人： Shana Kelley , Mark Pereira
CPC分类号： A61K47/48246 , A61K38/08 , A61K47/64 , A61K47/645 , C07K7/06
摘要： There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.
摘要翻译： 在本文中描述了包含与抗微生物结合的线粒体穿透肽（MPP）的化合物及其使用方法。
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4.发明申请公开(公告)号：US20110233075A1
公开(公告)日：2011-09-29
申请号：US13061465
申请日：2009-09-01
申请人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.
摘要翻译： 本文公开了纳米结构微电极和结合其的生物感测装置。
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公开(公告)号：US20180292305A1
公开(公告)日：2018-10-11
申请号：US15764030
申请日：2016-09-27
申请人： Shana KELLEY , Edward SARGENT , Mahla POUDINEH , Reza MOHAMADI , Peter ALDRIDGE
发明人： Shana KELLEY , Edward SARGENT , Mahla POUDINEH , Reza MOHAMADI , Peter ALDRIDGE
CPC分类号： G01N15/1484 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , B03C1/0332 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , G01N15/1475 , G01N33/491 , G01N33/57492 , G01N2015/1006 , G01N2015/149
摘要： Methods and devices for magnetic profiling of target particles in a flow. There are a plurality of flow rate-reducing structures in a flow chamber. Each flow rate-reducing structure is provided with a localized magnetic attractive force, the magnetic attractive force defining a capture zone in the vicinity of the flow rate-reducing structure. The size of capture zones may be variable for different locations within the device. The magnetic attractive force, in the capture zone, is sufficiently high to overcome the drag force on a given subset of the target particles to promote capture of any particles belonging to the subset of the target particles in the capture zone. Different target particles having different magnetic susceptibility are captured in different capture zones.
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公开(公告)号：US09132198B2
公开(公告)日：2015-09-15
申请号：US13700970
申请日：2011-05-27
申请人： Shana Kelley , Mark Pereira , Sonali Fonseca
发明人： Shana Kelley , Mark Pereira , Sonali Fonseca
CPC分类号： A61K47/48 , A61K38/00 , A61K47/64 , A61K47/645 , C07K7/06
摘要： There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anticancer compound, and their method of use.
摘要翻译： 本文描述了包含与抗癌化合物缀合的线粒体穿透肽（MPP）的化合物及其使用方法。
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7.发明申请公开(公告)号：US20130172266A1
公开(公告)日：2013-07-04
申请号：US13700970
申请日：2011-05-27
申请人： Shana Kelley , Mark Pereira , Sonali Fonseca
发明人： Shana Kelley , Mark Pereira , Sonali Fonseca
IPC分类号： A61K47/48
CPC分类号： A61K47/48 , A61K38/00 , A61K47/64 , A61K47/645 , C07K7/06
摘要： There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anti-cancer compound, and their method of use.
摘要翻译： 本文描述了包含与抗癌化合物缀合的线粒体穿透肽（MPP）的化合物及其使用方法。
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公开(公告)号：US20130157931A1
公开(公告)日：2013-06-20
申请号：US13700988
申请日：2011-05-27
申请人： Shana Kelley , Mark Pereira
发明人： Shana Kelley , Mark Pereira
IPC分类号： A61K47/48
CPC分类号： A61K47/48246 , A61K38/08 , A61K47/64 , A61K47/645 , C07K7/06
摘要： There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.
摘要翻译： 在本文中描述了包含与抗微生物结合的线粒体穿透肽（MPP）的化合物及其使用方法。
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公开(公告)号：US20060223079A1
公开(公告)日：2006-10-05
申请号：US11270983
申请日：2005-11-11
CPC分类号： C12Q1/6825 , C12Q2563/137
摘要： The detection of specific DNA sequences using electrochemical readout would permit the rapid and inexpensive detection and identification of bacterial pathogens and the analysis of human genes. A new assay developed for this purpose is described that harnesses an electrocatalytic process to monitor DNA hybridization.
摘要翻译： 使用电化学读数检测特异性DNA序列将允许快速和便宜地检测和鉴定细菌病原体并分析人类基因。 描述了为此目的开发的新测定法，利用电催化过程来监测DNA杂交。
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公开(公告)号：US20050084881A1
公开(公告)日：2005-04-21
申请号：US10913925
申请日：2004-08-06
CPC分类号： C12Q1/6825 , G01N27/3278 , C12Q2563/173 , C12Q2563/155 , C12Q2563/113
摘要： The detection of specific nucleic acid sequences using electrochemical readout would permit the rapid and inexpensive detection and identification of bacterial pathogens and the analysis of human genes. A new assay developed for this purpose is described that harnesses an electrocatalytic process to monitor nucleic acid hybridization. Furthermore, the new assay when used on nanoscale electrodes, provides ultrasensitive detection of nucleic acids.
摘要翻译： 使用电化学读数检测特异性核酸序列将允许快速和便宜地检测和鉴定细菌病原体并分析人类基因。 描述了为此目的开发的新的测定法，其利用电催化过程来监测核酸杂交。 此外，当用于纳米尺度电极时的新测定提供核酸的超敏感检测。
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