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    Method for producing micro-nano combined active systems
    1.
    发明授权
    Method for producing micro-nano combined active systems 有权
    微纳结合活性体系的制备方法

    公开(公告)号：US09403160B2

    公开(公告)日：2016-08-02

    申请号：US13994054

    申请日：2011-12-16

    申请人： Stephan Barcikowski ,  Philipp Wagener ,  Andreas Schwenke

    发明人： Stephan Barcikowski ,  Philipp Wagener ,  Andreas Schwenke

    IPC分类号： B01J35/00 ,  C08K3/00 ,  B82Y30/00

    CPC分类号： B01J35/0006 ,  B82Y30/00 ,  C08K3/01 ,  C08K3/105 ,  C08K3/11

    摘要： The invention relates to a method for producing micro-nano combined active systems in which nanoparticles of a first component are bonded to microparticles of a second component, comprising the following steps: (a) producing a low-ligand colloidal suspension containing nanoparticles of the first component, (b) adding microparticles to the colloidal suspension containing the nanoparticles or adding the colloidal suspension containing the nanoparticles to a dispersion containing the microparticles and intensively mixing so that the nanoparticles adsorb onto the microparticles, (c) separating the microparticles and the nanoparticles bonded thereto from the liquid and drying the microparticles and the nanoparticles bonded thereto.

    摘要翻译： 本发明涉及一种用于生产微纳米组合活性体系的方法，其中第一组分的纳米颗粒与第二组分的微粒结合，包括以下步骤：（a）制备含有第一组分的纳米颗粒的低配体胶体悬浮液 （b）将微粒添加到含有纳米颗粒的胶体悬浮液中，或者将含有纳米颗粒的胶体悬浮液加入到含有微粒的分散体中并进行强烈混合，使纳米粒子吸附在微粒上，（c）将微粒与纳米颗粒结合 从液体中取出并干燥微粒和与其结合的纳米颗粒。

    METHOD FOR PRODUCING MICRO-NANO COMBINED ACTIVE SYSTEMS
    3.
    发明申请
    METHOD FOR PRODUCING MICRO-NANO COMBINED ACTIVE SYSTEMS 有权
    生产微纳米组合活性体系的方法

    公开(公告)号：US20130331257A1

    公开(公告)日：2013-12-12

    申请号：US13994054

    申请日：2011-12-16

    申请人： Stephan Barcikowski ,  Philipp Wagener ,  Andreas Schwenke

    发明人： Stephan Barcikowski ,  Philipp Wagener ,  Andreas Schwenke

    IPC分类号： B01J35/00

    CPC分类号： B01J35/0006 ,  B82Y30/00 ,  C08K3/01 ,  C08K3/105 ,  C08K3/11

    摘要： The invention relates to a method for producing micro-nano combined active systems in which nanoparticles of a first component are bonded to microparticles of a second component, comprising the following steps: (a) producing a low-ligand colloidal suspension containing nanoparticles of the first component, (b) adding microparticles to the colloidal suspension containing the nanoparticles or adding the colloidal suspension containing the nanoparticles to a dispersion containing the microparticles and intensively mixing so that the nanoparticles adsorb onto the microparticles, (c) separating the microparticles and the nanoparticles bonded thereto from the liquid and drying the microparticles and the nanoparticles bonded thereto.

    摘要翻译： 本发明涉及一种生产微纳米组合活性体系的方法，其中第一组分的纳米颗粒与第二组分的微粒结合，包括以下步骤：（a）制备含有第一组分的纳米颗粒的低配位体胶体悬浮液 （b）将微粒添加到含有纳米颗粒的胶体悬浮液中，或者将含有纳米颗粒的胶体悬浮液加入到含有微粒的分散体中并进行强烈混合，使纳米粒子吸附在微粒上，（c）将微粒与纳米颗粒结合 从液体中取出并干燥微粒和与其结合的纳米颗粒。

    METHOD AND DEVICE FOR PRODUCING METAL-CONTAINING ORGANIC COMPOUNDS
    4.
    发明申请
    METHOD AND DEVICE FOR PRODUCING METAL-CONTAINING ORGANIC COMPOUNDS 有权
    用于生产含金属有机化合物的方法和装置

    公开(公告)号：US20110189695A1

    公开(公告)日：2011-08-04

    申请号：US13003720

    申请日：2009-07-15

    申请人： Stephan Barcikowski ,  Svea Petersen

    发明人： Stephan Barcikowski ,  Svea Petersen

    IPC分类号： G01N33/53 ,  C07H21/04 ,  B01J19/08

    CPC分类号： G01N33/532 ,  C12N5/0612 ,  G01N33/54313 ,  G01N33/54346

    摘要： The invention relates to a method and to a device for producing conjugates comprising or consisting of a metallic nanoparticulate component and an organic component. Said method enables activated or reactive nanoparticles containing metal to be produced by irradiating a metal body with a laser beam and prevents the modification and damage of organic components of said conjugates by laser irradiation. Said nanoparticulate metallic component comprises plasmon resonant metal. According to the invention, the claimed method of production enables particles having a metal centre and a metal-oxide covering to be produced, in particular when using a carrier fluid containing oxygen, e.g. alcohol or water.

    摘要翻译： 本发明涉及包含或由金属纳米颗粒组分和有机组分组成的缀合物的方法和装置。 所述方法能够通过用激光束照射金属体来产生含金属的活性或反应性纳米颗粒，并通过激光照射来防止所述共轭物的有机组分的改性和损坏。 所述纳米颗粒金属组分包括等离子体共振金属。 根据本发明，所要求的生产方法使得能够生产具有金属中心和金属氧化物覆盖层的颗粒，特别是当使用含氧的载体流体时。 酒精或水。

    IMPLANT AND METHOD FOR ITS MANUFACTURE
    5.
    发明申请
    IMPLANT AND METHOD FOR ITS MANUFACTURE 审中-公开
    植物及其制造方法

    公开(公告)号：US20100178311A1

    公开(公告)日：2010-07-15

    申请号：US12452335

    申请日：2008-06-27

    申请人： Stephan Barcikowski ,  Andreas Schuessler

    发明人： Stephan Barcikowski ,  Andreas Schuessler

    IPC分类号： A61F2/82 ,  C25D13/10 ,  C25D13/12

    CPC分类号： A61L31/022 ,  A61L31/082 ,  A61L2400/12

    摘要： The invention is directed to an implant (1) with a main body (2) having a surface (5,6), and with a coating (7) of nanoparticles (8) provided at least on portions of the surface (5,6) of the main body (2), wherein the main body (2) is made from a material with a metal lattice structure, and the nanoparticles (8) of the coating (7) comprise a material which also has a metal lattice structure. The implant is characterized by the lattice structure of the material of the nanoparticles (8) being compatible in such a way to the lattice structure of the material of the main body (2), that both materials are mutually connectable by a diffusion process, in particular by a diffusion joining process. The invention is also directed to a method for manufacturing such an implant, wherein the method of manufacturing allows the simultaneous coating of a plurality of implants (1) under “mild” process conditions.

    摘要翻译： 本发明涉及具有主体（2）的植入物（1），其具有表面（5,6），并且具有至少在表面的部分（5,6）上提供的纳米颗粒（8）的涂层（7） ），其中主体（2）由具有金属格子结构的材料制成，并且涂层（7）的纳米颗粒（8）包括也具有金属晶格结构的材料。 植入物的特征在于纳米颗粒（8）的材料的晶格结构以这样的方式与主体（2）的材料的晶格结构相容，两种材料可通过扩散过程相互连接，在 特别是通过扩散接合过程。 本发明还涉及一种用于制造这种植入物的方法，其中制造方法允许在“温和的”工艺条件下同时涂覆多个植入物（1）。

    Method and device for producing metal-containing organic compounds
    6.
    发明授权
    Method and device for producing metal-containing organic compounds 有权
    用于生产含金属有机化合物的方法和装置

    公开(公告)号：US09097709B2

    公开(公告)日：2015-08-04

    申请号：US13003720

    申请日：2009-07-15

    申请人： Stephan Barcikowski ,  Svea Petersen

    发明人： Stephan Barcikowski ,  Svea Petersen

    IPC分类号： G01N33/532 ,  G01N33/543 ,  C12N5/071

    CPC分类号： G01N33/532 ,  C12N5/0612 ,  G01N33/54313 ,  G01N33/54346

    摘要： The invention relates to a method and to a device for producing conjugates comprising or consisting of a metallic nanoparticulate component and an organic component. Said method enables activated or reactive nanoparticles containing metal to be produced by irradiating a metal body with a laser beam and prevents the modification and damage of organic components of said conjugates by laser irradiation. Said nanoparticulate metallic component comprises plasmon resonant metal. According to the invention, the claimed method of production enables particles having a metal centre and a metal-oxide covering to be produced, in particular when using a carrier fluid containing oxygen, e.g. alcohol or water.

    摘要翻译： 本发明涉及包含或由金属纳米颗粒组分和有机组分组成的缀合物的方法和装置。 所述方法能够通过用激光束照射金属体来产生含金属的活性或反应性纳米颗粒，并通过激光照射来防止所述共轭物的有机组分的改性和损坏。 所述纳米颗粒金属组分包括等离子体共振金属。 根据本发明，所要求的生产方法使得能够生产具有金属中心和金属氧化物覆盖层的颗粒，特别是当使用含氧的载体流体时，例如， 酒精或水。

    BIOLOGICALLY ACTIVE DEVICE AND METHOD FOR ITS PRODUCTION
    9.
    发明申请
    BIOLOGICALLY ACTIVE DEVICE AND METHOD FOR ITS PRODUCTION 审中-公开
    生物活性物质及其生产方法

    公开(公告)号：US20100291174A1

    公开(公告)日：2010-11-18

    申请号：US12449311

    申请日：2008-02-01

    申请人： Stephan Barcikowski ,  Thomas Lenarz ,  Timo Stoever

    发明人： Stephan Barcikowski ,  Thomas Lenarz ,  Timo Stoever

    IPC分类号： A61F2/00 ,  A61K33/42 ,  A61K33/38 ,  A61K33/34 ,  A61K33/30 ,  A61K9/00 ,  A61F2/82 ,  A61F2/24 ,  A61F2/06 ,  A61M25/00 ,  A61F2/18 ,  A61P41/00 ,  B29C35/08 ,  C12N5/07

    CPC分类号： A61L31/16 ,  A61L27/446 ,  A61L27/54 ,  A61L31/128 ,  A61L2300/102 ,  A61L2300/624 ,  A61L2400/12 ,  B22F1/0059 ,  B22F3/225

    摘要： The present invention is directed to a biologically active device with a main body made from a polymer, in which bioactive nanoparticles of one or several materials are embedded, wherein the nanoparticles of at least one material proliferatively act on a biological material contacted by the device, and wherein nanoparticles of a different material act in an anti-proliferative manner on biological material in the ambience of the device. The invention is also directed to a method of manufacturing a biologically active device with a main body made from a polymer, wherein nanoparticles of several different materials are dispersed in an injection-moldable fluid, and the fluid is shaped into the polymer main body by means of injection molding and curing, such that the nanoparticles are dispersed in the bulk of the polymer main body. According to the invention, the nanoparticles are generated by arranging at least two substrates of different material in a vessel filled with a fluid material, and by generating the nanoparticles by abrasion from the surface of the substrates in the fluid with laser radiation.

    摘要翻译： 本发明涉及具有由聚合物制成的主体的生物活性器件，其中嵌入了一种或几种材料的生物活性纳米颗粒，其中至少一种材料的纳米颗粒增殖作用于与该器件接触的生物材料上， 并且其中不同材料的纳米颗粒在器件的环境中以抗增殖方式作用于生物材料。 本发明还涉及制造具有由聚合物制成的主体的生物活性器件的方法，其中将几种不同材料的纳米颗粒分散在可注射成型的流体中，并且流体通过装置成形为聚合物主体 的注塑和固化，使得纳米颗粒分散在聚合物主体的本体中。 根据本发明，通过在填充有流体材料的容器中布置不同材料的至少两个衬底，并且通过用激光辐射从流体中的衬底的表面磨损产生纳米颗粒来产生纳米颗粒。