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1.Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 有权
标题翻译: 用于抑制ABL1,ABL2和BCR-ABL1活性的化合物和组合物公开(公告)号:US08829195B2
公开(公告)日:2014-09-09
申请号:US13892769
申请日:2013-05-13
申请人: Stephanie Kay Dodd , Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer
发明人: Stephanie Kay Dodd , Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer
IPC分类号: C07D401/00 , C07D211/72 , C07D211/84 , C07D211/56 , A01N43/40 , A61K31/44 , C07D405/14 , C07D401/10 , C07D401/04 , C07D213/82 , A61K45/06 , C07D403/10 , C07F9/58 , A61K31/4439 , A61K31/506 , C07D401/14
CPC分类号: C07D213/82 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07F9/58
摘要: The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
摘要翻译: 本发明涉及式(I)化合物:其中Y,Y 1,R 1,R 2,R 3和R 4在发明概述中定义; 能够抑制BCR-ABL1及其突变体的活性。 本发明还提供了制备本发明化合物的方法,包含这些化合物的药物制剂和使用这些化合物治疗癌症的方法。
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2.
公开(公告)号:US20120035174A1
公开(公告)日:2012-02-09
申请号:US13272814
申请日:2011-10-13
申请人: Joginder Singh Bajwa , Marilyn De La Cruz , Stephanie Kay Dodd , Liladhar Murlidhar Waykole , Raeann Wu
发明人: Joginder Singh Bajwa , Marilyn De La Cruz , Stephanie Kay Dodd , Liladhar Murlidhar Waykole , Raeann Wu
IPC分类号: A61K31/5377 , A61P35/00 , A61P35/02 , C07D413/04
CPC分类号: C07D413/04
摘要: Salts of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4′-(trifluoromethoxy)[1,1′-biphenyl]-3-carboxamide are prepared and characterized.
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公开(公告)号:US20140171363A1
公开(公告)日:2014-06-19
申请号:US14188647
申请日:2014-02-24
申请人: David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON, II , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , SU Liansheng
发明人: David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON, II , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , SU Liansheng
IPC分类号: A61K31/542 , A61K31/4184 , C07D235/12 , C07D403/04 , C07D405/04 , C07D235/30 , C07D235/16 , C07D405/14 , A61K31/496 , C07D263/57 , A61K31/423 , C07D209/24 , A61K31/404 , C07D413/12 , A61K31/5377 , C07D513/04 , A61K45/06 , C07D235/08
CPC分类号: A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要: The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
摘要翻译: 本发明提供式(I)化合物; 或其药学上可接受的盐,其中变量如本文所定义。 本发明提供了制备式(I)化合物,其治疗用途,与其他药理学活性剂的组合以及药物组合物的方法。
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公开(公告)号:US08697739B2
公开(公告)日:2014-04-15
申请号:US13189760
申请日:2011-07-25
申请人: David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su
发明人: David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su
IPC分类号: C07D215/00 , C07D235/04 , A61K31/4985 , A61K31/47
CPC分类号: A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要: The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
摘要翻译: 本发明提供式(I)化合物; 或其药学上可接受的盐,其中变量如本文所定义。 本发明提供了制备式(I)化合物,其治疗用途,与其他药理学活性剂的组合以及药物组合物的方法。
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公开(公告)号:US20120028969A1
公开(公告)日:2012-02-02
申请号:US13189760
申请日:2011-07-25
申请人: David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , Liansheng SU
发明人: David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , Liansheng SU
IPC分类号: A61K31/542 , A61K31/5365 , A61K31/5377 , A61K31/4985 , A61K31/47 , A61K31/4245 , A61K31/4184 , A61K31/405 , C07D513/04 , C07D498/04 , C07D413/12 , C07D471/04 , C07D215/00 , C07D235/04 , C07D209/04 , A61P31/12 , A61P3/10 , A61P3/08 , A61P3/04 , A61P3/06 , A61P3/00 , C12N9/99
CPC分类号: A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要: The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
摘要翻译: 本发明提供式(I)化合物; 或其药学上可接受的盐,其中变量如本文所定义。 本发明提供了制备式(I)化合物,其治疗用途,与其他药理学活性剂的组合以及药物组合物的方法。
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公开(公告)号:US20170275264A1
公开(公告)日:2017-09-28
申请号:US15452430
申请日:2017-03-07
申请人: Yves AUBERSON , Mark Gary BOCK , Dario BRAGA , Marco CURZI , Stephanie Kay DODD , Stefano Luca GIAFFREDA , Haiyang JIANG , Piotr KARPINSKI , Thomas J. TROXLER , Tie-Lin WANG , Xiaoyang WANG , Xuechun ZHANG
发明人: Yves AUBERSON , Mark Gary BOCK , Dario BRAGA , Marco CURZI , Stephanie Kay DODD , Stefano Luca GIAFFREDA , Haiyang JIANG , Piotr KARPINSKI , Thomas J. TROXLER , Tie-Lin WANG , Xiaoyang WANG , Xuechun ZHANG
IPC分类号: C07D401/04 , C07D403/04 , C07C57/15 , C07C59/265 , A61K31/496 , A61K31/501
CPC分类号: C07D401/04 , A61K31/496 , A61K31/501 , C07B2200/13 , C07C57/15 , C07C59/265 , C07D403/04
摘要: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
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公开(公告)号:US09624192B2
公开(公告)日:2017-04-18
申请号:US15049739
申请日:2016-02-22
申请人: Yves Auberson , Mark Gary Bock , Dario Braga , Marco Curzi , Stephanie Kay Dodd , Stefano Luca Giaffreda , Haiyang Jiang , Piotr Karpinski , Thomas J. Troxler , Tie-Lin Wang , Xiaoyang Wang , Xuechun Zhang
发明人: Yves Auberson , Mark Gary Bock , Dario Braga , Marco Curzi , Stephanie Kay Dodd , Stefano Luca Giaffreda , Haiyang Jiang , Piotr Karpinski , Thomas J. Troxler , Tie-Lin Wang , Xiaoyang Wang , Xuechun Zhang
IPC分类号: A61K31/501 , C07D401/04 , A61K31/496 , C07C57/15 , C07C59/265 , C07D403/04
CPC分类号: C07D401/04 , A61K31/496 , A61K31/501 , C07B2200/13 , C07C57/15 , C07C59/265 , C07D403/04
摘要: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
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公开(公告)号:US09273026B2
公开(公告)日:2016-03-01
申请号:US14685926
申请日:2015-04-14
申请人: Yves Auberson , Mark Gary Bock , Dario Braga , Marco Curzi , Stephanie Kay Dodd , Stefano Luca Giaffreda , Hayang Jiang , Piotr Karpinski , Thomas J. Troxler , Tie-Lin Wang , Xiaoyang Wang , Xuechun Zhang
发明人: Yves Auberson , Mark Gary Bock , Dario Braga , Marco Curzi , Stephanie Kay Dodd , Stefano Luca Giaffreda , Hayang Jiang , Piotr Karpinski , Thomas J. Troxler , Tie-Lin Wang , Xiaoyang Wang , Xuechun Zhang
IPC分类号: A61K31/501 , C07D401/04 , A61K31/496 , C07C57/15 , C07C59/265 , C07D403/04
CPC分类号: C07D401/04 , A61K31/496 , A61K31/501 , C07B2200/13 , C07C57/15 , C07C59/265 , C07D403/04
摘要: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
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公开(公告)号:US09034874B2
公开(公告)日:2015-05-19
申请号:US13944354
申请日:2013-07-17
申请人: Yves Auberson , Mark Gary Bock , Dario Braga , Marco Curzi , Stephanie Kay Dodd , Stefano Luca Giaffreda , Haiyang Jiang , Piotr Karpinski , Thomas J. Troxler , Tielin Wang , Xiaoyang Wang , Xuechun Zhang
发明人: Yves Auberson , Mark Gary Bock , Dario Braga , Marco Curzi , Stephanie Kay Dodd , Stefano Luca Giaffreda , Haiyang Jiang , Piotr Karpinski , Thomas J. Troxler , Tielin Wang , Xiaoyang Wang , Xuechun Zhang
IPC分类号: A61K31/496 , A61K31/501 , C07D401/04 , C07D403/04 , C07C57/15 , C07C59/265
CPC分类号: C07D401/04 , A61K31/496 , A61K31/501 , C07B2200/13 , C07C57/15 , C07C59/265 , C07D403/04
摘要: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译: 本发明涉及式I化合物或其盐,其中取代基如说明书中所定义; 作为其制备,用作药物和包含它的药物。
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10.COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 审中-公开
标题翻译: 抑制ABL1,ABL2和BCR-ABL1活性的化合物和组合物公开(公告)号:US20140343086A1
公开(公告)日:2014-11-20
申请号:US14448363
申请日:2014-07-31
申请人: Stephanie Kay DODD , Pascal FURET , Robert Martin GROTZFELD , Wolfgang JAHNKE , Darryl Brynley JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER
发明人: Stephanie Kay DODD , Pascal FURET , Robert Martin GROTZFELD , Wolfgang JAHNKE , Darryl Brynley JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER
IPC分类号: C07D213/82 , A61K31/506 , C07D401/14 , C07D401/04 , A61K31/4439 , C07D405/14
CPC分类号: C07D213/82 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07F9/58
摘要: The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
摘要翻译: 本发明涉及式(I)化合物:其中Y,Y 1,R 1,R 2,R 3和R 4在发明概述中定义; 能够抑制BCR-ABL1及其突变体的活性。 本发明还提供了制备本发明化合物的方法,包含这些化合物的药物制剂和使用这些化合物治疗癌症的方法。
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