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公开(公告)号：US08394858B2
公开(公告)日：2013-03-12
申请号：US12956146
申请日：2010-11-30
申请人： David Barnes , Gregory Raymond Bebernitz , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Herbert Franz Schuster , Wei Zhang
发明人： David Barnes , Gregory Raymond Bebernitz , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Herbert Franz Schuster , Wei Zhang
IPC分类号： A01N37/18 , A61K31/16 , C07C327/48
CPC分类号： C07D413/10 , C07B2200/05 , C07C311/20 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/44 , C07C2603/74 , C07D207/06 , C07D207/08 , C07D207/263 , C07D211/16 , C07D211/18 , C07D213/40 , C07D213/71 , C07D241/04 , C07D241/08 , C07D265/30 , C07D277/26 , C07D279/12 , C07D295/088 , C07D401/06
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20140171363A1
公开(公告)日：2014-06-19
申请号：US14188647
申请日：2014-02-24
申请人： David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON, II , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , SU Liansheng
发明人： David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON, II , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , SU Liansheng
IPC分类号： A61K31/542 , A61K31/4184 , C07D235/12 , C07D403/04 , C07D405/04 , C07D235/30 , C07D235/16 , C07D405/14 , A61K31/496 , C07D263/57 , A61K31/423 , C07D209/24 , A61K31/404 , C07D413/12 , A61K31/5377 , C07D513/04 , A61K45/06 , C07D235/08
CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要： The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
摘要翻译： 本发明提供式（I）化合物; 或其药学上可接受的盐，其中变量如本文所定义。 本发明提供了制备式（I）化合物，其治疗用途，与其他药理学活性剂的组合以及药物组合物的方法。
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公开(公告)号：US08697739B2
公开(公告)日：2014-04-15
申请号：US13189760
申请日：2011-07-25
申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su
发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su
IPC分类号： C07D215/00 , C07D235/04 , A61K31/4985 , A61K31/47
CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要： The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
摘要翻译： 本发明提供式（I）化合物; 或其药学上可接受的盐，其中变量如本文所定义。 本发明提供了制备式（I）化合物，其治疗用途，与其他药理学活性剂的组合以及药物组合物的方法。
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公开(公告)号：US20120028969A1
公开(公告)日：2012-02-02
申请号：US13189760
申请日：2011-07-25
申请人： David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , Liansheng SU
发明人： David Weninger BARNES , Gregory Raymond BEBERNITZ , Kevin CLAIRMONT , Scott Louis COHEN , Robert Edson DAMON , Robert Francis DAY , Stephanie Kay DODD , Christoph GAUL , Hatice Belgin GULGEZE EFTHYMIOU , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Kai LIN , Justin Yik Ching MAO , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , Liansheng SU
IPC分类号： A61K31/542 , A61K31/5365 , A61K31/5377 , A61K31/4985 , A61K31/47 , A61K31/4245 , A61K31/4184 , A61K31/405 , C07D513/04 , C07D498/04 , C07D413/12 , C07D471/04 , C07D215/00 , C07D235/04 , C07D209/04 , A61P31/12 , A61P3/10 , A61P3/08 , A61P3/04 , A61P3/06 , A61P3/00 , C12N9/99
CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要： The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
摘要翻译： 本发明提供式（I）化合物; 或其药学上可接受的盐，其中变量如本文所定义。 本发明提供了制备式（I）化合物，其治疗用途，与其他药理学活性剂的组合以及药物组合物的方法。
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公开(公告)号：US09789118B2
公开(公告)日：2017-10-17
申请号：US14188647
申请日：2014-02-24
申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng
发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng
IPC分类号： C07D215/36 , C07D235/18 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/12 , C07D471/04 , C07D513/04 , A61K31/542 , A61K31/4184 , A61K9/00 , A61K9/08 , A61K9/107 , C12N9/00 , A61K31/404 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/30 , C07D405/14
CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要： The present invention provides compounds of formula (IV); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (IV), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
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公开(公告)号：US20110136735A1
公开(公告)日：2011-06-09
申请号：US12956146
申请日：2010-11-30
申请人： David BARNES , Gregory Raymond BEBERNITZ , Scott Louis COHEN , Robert Edson DAMON , Robert Francis DAY , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , Herbert Franz SCHUSTER , Wei ZHANG
发明人： David BARNES , Gregory Raymond BEBERNITZ , Scott Louis COHEN , Robert Edson DAMON , Robert Francis DAY , Monish JAIN , Rajeshri Ganesh KARKI , Louise Clare KIRMAN , Tajesh Jayprakash PATEL , Brian Kenneth RAYMER , Herbert Franz SCHUSTER , Wei ZHANG
IPC分类号： A61K31/18 , C07C311/20 , C07C311/29 , C07D413/12 , A61K31/496 , C07D211/18 , A61K31/451 , C07D207/06 , A61K31/40 , C07D265/30 , A61K31/5375 , C07D279/12 , A61K31/54 , C07D401/06 , A61K31/5377 , C07D213/71 , A61K31/4418 , C07D263/32 , A61K31/421 , C07D235/02 , A61K31/4184 , C07F9/09 , A61K31/661 , A61P3/10 , A61K38/28 , A61K31/60 , A61K38/26 , A61P3/04 , A61P9/12 , A61P3/00 , C12N9/99
CPC分类号： C07D413/10 , C07B2200/05 , C07C311/20 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/44 , C07C2603/74 , C07D207/06 , C07D207/08 , C07D207/263 , C07D211/16 , C07D211/18 , C07D213/40 , C07D213/71 , C07D241/04 , C07D241/08 , C07D265/30 , C07D277/26 , C07D279/12 , C07D295/088 , C07D401/06
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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