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    Ddr2 protein with activated kinase activity and preparation method thereof
    2.
    发明申请
    Ddr2 protein with activated kinase activity and preparation method thereof 审中-公开
    具有活化激酶活性的Ddr2蛋白及其制备方法

    公开(公告)号：US20070128609A1

    公开(公告)日：2007-06-07

    申请号：US10595585

    申请日：2004-11-01

    申请人： Beom-Seok Yang ,  Sung-Dae Park

    发明人： Beom-Seok Yang ,  Sung-Dae Park

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12 ,  C12N5/06 ,  C12N15/86

    CPC分类号： C07K14/705 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/35 ,  C12N9/1205

    摘要： The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase activity by inducing phosphorylations of tyrosines by a co-expression with Src or Src related proteins in host cells, or by H2O2 processing of host cells, or a site directed mutation modifying at least one of tyrosines to other amino acid; and a use thereof as a target material in developing medical drugs for treating a disease caused by an excessively activated DDR2 autophosphorylation and tyrosine kinase activity.

    摘要翻译： 本发明涉及含有增加的自磷酸化和酪氨酸激酶活性的修饰的DDR（盘带蛋白结构域受体）2胞质酪氨酸激酶结构域的蛋白质; 通过与宿主细胞中的Src或Src相关蛋白的共表达，或通过H 2 O 2处理，通过诱导酪氨酸的磷酸化，具有增加的自磷酸化和酪氨酸激酶活性的DDR2胞质酪氨酸激酶结构域的蛋白质的制备方法 宿主细胞或将至少一种酪氨酸修饰至其它氨基酸的位点定向突变; 以及其用作开发用于治疗由过度活化的DDR2自磷酸化和酪氨酸激酶活性引起的疾病的药物的目标材料。

    SOI semiconductor integrated circuit for eliminating floating body effects in SOI MOSFETs and method of fabricating the same
    3.
    发明授权
    SOI semiconductor integrated circuit for eliminating floating body effects in SOI MOSFETs and method of fabricating the same 有权
    用于消除SOI MOSFET中的浮体效应的SOI半导体集成电路及其制造方法

    公开(公告)号：US06521959B2

    公开(公告)日：2003-02-18

    申请号：US09782116

    申请日：2001-02-13

    申请人： Young-Wug Kim ,  Byung-Sun Kim ,  Hee-Sung Kang ,  Young-Gun Ko ,  Sung-Dae Park ,  Min-Su Kim ,  Kwang-Il Kim

    发明人： Young-Wug Kim ,  Byung-Sun Kim ,  Hee-Sung Kang ,  Young-Gun Ko ,  Sung-Dae Park ,  Min-Su Kim ,  Kwang-Il Kim

    IPC分类号： H01L2972

    CPC分类号： H01L29/78615

    摘要： A silicon-on-insulator (SOI) integrated circuit and a method of fabricating the SOI integrated circuit are provided. At least one isolated transistor active region and a body line are formed on an SOI substrate. The transistor active region and the body line are surrounded by an isolation layer which is in contact with a buried insulating layer of the SOI substrate. A portion of the sidewall of the transistor active region is extended to the body line. Thus, the transistor active region is electrically connected to the body line through a body extension. The body extension is covered with a body insulating layer. An insulated gate pattern is formed over the transistor active region, and one end of the gate pattern is overlapped with the body insulating layer.

    摘要翻译： 提供了绝缘体上硅（SOI）集成电路和制造SOI集成电路的方法。 在SOI衬底上形成至少一个隔离晶体管有源区和体线。 晶体管有源区和体线被与SOI衬底的掩埋绝缘层接触的隔离层围绕。 晶体管有源区的侧壁的一部分延伸到主体线。 因此，晶体管有源区域通过主体延伸部电连接到主体线路。 身体延伸部分覆盖有身体绝缘层。 绝缘栅图案形成在晶体管有源区上方，栅极图案的一端与主体绝缘层重叠。

    DDR2 PROTEIN WITH ACTIVATED KINASE ACTIVITY AND PREPARATION METHOD THEREOF
    5.
    发明申请
    DDR2 PROTEIN WITH ACTIVATED KINASE ACTIVITY AND PREPARATION METHOD THEREOF 审中-公开
    具有活性激酶活性的DDR2蛋白及其制备方法

    公开(公告)号：US20120270234A1

    公开(公告)日：2012-10-25

    申请号：US12987863

    申请日：2011-01-10

    申请人： Beom-Seok YANG ,  Sung-Dae Park

    发明人： Beom-Seok YANG ,  Sung-Dae Park

    IPC分类号： C12N9/12 ,  C12Q1/48 ,  G01N21/76 ,  C12N15/866

    CPC分类号： C07K14/705 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/35 ,  C12N9/1205

    摘要： The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase activity by inducing phosphorylations of tyrosines by a co-expression with Src or Src related proteins in host cells, or by H2O2 processing of host cells, or a site directed mutation modifying at least one of tyrosines to other amino acid; and a use thereof as a target material in developing medical drugs for treating a disease caused by an excessively activated DDR2 autophosphorylation and tyrosine kinase activity.

    摘要翻译： 本发明涉及含有增加的自磷酸化和酪氨酸激酶活性的修饰的DDR（盘带蛋白结构域受体）2胞质酪氨酸激酶结构域的蛋白质; 通过与宿主细胞中的Src或Src相关蛋白的共表达，或通过H 2 O 2处理，通过诱导酪氨酸的磷酸化，具有增加的自磷酸化和酪氨酸激酶活性的DDR2胞质酪氨酸激酶结构域的蛋白质的制备方法 宿主细胞或将至少一种酪氨酸修饰至其它氨基酸的位点定向突变; 以及其用作开发用于治疗由过度活化的DDR2自磷酸化和酪氨酸激酶活性引起的疾病的药物的目标材料。

    Benzopyran derivatives
    10.
    发明授权
    Benzopyran derivatives 有权
    苯并吡喃衍生物

    公开(公告)号：US6153768A

    公开(公告)日：2000-11-28

    申请号：US319616

    申请日：1999-06-08

    申请人： Jae Chon Jo ,  Sung Dae Park ,  Hyun Suk Lim ,  Ju Su Kim ,  Sung Jin Kim ,  Kazumi Morikawa ,  Yoshitake Kanbe ,  Masahiro Nishimoto ,  Myung-Hwa Kim

    发明人： Jae Chon Jo ,  Sung Dae Park ,  Hyun Suk Lim ,  Ju Su Kim ,  Sung Jin Kim ,  Kazumi Morikawa ,  Yoshitake Kanbe ,  Masahiro Nishimoto ,  Myung-Hwa Kim

    IPC分类号： A61K31/352 ,  A61K31/353 ,  A61K31/382 ,  A61K31/453 ,  A61K31/496 ,  A61P5/32 ,  A61P15/00 ,  C07D311/38 ,  C07D311/58 ,  C07D335/06 ,  C07D311/04

    CPC分类号： C07D335/06 ,  C07D311/38 ,  C07D311/58

    摘要： The present invention relates to a novel benzopyran derivative having anti-estrogenic activity. More specifically, the present invention relates to a novel benzopyran derivative represented by formula (I) and pharmaceutically acceptable salt thereof, in which ----- represents a single bond or a double bond; R1 and R2 independently of one another represent hydrogen, hydroxy or OR group, wherein R represents acyl or alkyl; R3 represents hydrogen, lower alkyl or halogeno lower alkyl, provided that when ----- represents a double bond, R3 is not present; R4 represents hydrogen or lower alkyl; A represents a group of formula a, b, c or d; R5, R6 and R7 independently of one another represent hydrogen, alkyl, halogenoalkyl, alkenyl or halogenoalkenyl, or R6 and R7 together with nitrogen atom to which they are bound can form a 4- to 8-membered heterocyclic ring which can be substituted with R5; X represents O, S, or NR8, wherein R8 represents hydrogen or lower alkyl; m denotes an integer of 2 to 15; n denotes an integer of 0 to 2; and p denotes an integer of 0 to 4.

    摘要翻译： PCT No.PCT / KR97 / 00265 Sec。 371 1999年6月8日第 102（e）日期1999年6月8日PCT 1997年12月13日PCT公布。 公开号WO98 / 25916 PCT 日期：1998年6月18日本发明涉及具有抗雌激素活性的新型苯并吡喃衍生物。 更具体地说，本发明涉及由式（I）表示的新型苯并吡喃衍生物及其药学上可接受的盐，其中+ E，uns ----- + EE表示单键或双键; R 1和R 2彼此独立地表示氢，羟基或OR基，其中R表示酰基或烷基; R3表示氢，低级烷基或卤代低级烷基，条件是当+ E时，不为 - + EE表示双键，R3不存在; R4代表氢或低级烷基; A表示式a，b，c或d的基团; R 5，R 6和R 7彼此独立地表示氢，烷基，卤代烷基，烯基或卤代烯基，或者R 6和R 7与它们所连接的氮原子一起可以形成可被R 5取代的4至8元杂环 ; X表示O，S或NR8，其中R8表示氢或低级烷基; m表示2〜15的整数， n表示0〜2的整数， p表示0〜4的整数。