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1.发明申请公开(公告)号：US20100303774A1
公开(公告)日：2010-12-02
申请号：US12853110
申请日：2010-08-09
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译： 存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。
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2.发明申请RESORBABLE HOLLOW DEVICES FOR IMPLANTATION AND DELIVERY OF THERAPEUTIC AGENTS 有权用于植入和输送治疗药物的可分离的中空装置公开(公告)号：US20090259177A1
公开(公告)日：2009-10-15
申请号：US12424140
申请日：2009-04-15
CPC分类号： A61B17/7097 , A61B17/8833 , A61B17/8855 , A61B2017/00004 , A61B2017/8813 , A61B2017/883 , A61F2/44 , A61F2/4601 , A61F2002/30062 , A61F2002/30064 , A61M25/10 , A61M25/1029 , A61M31/002 , A61M2025/0057 , A61M2025/105
摘要： A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. Methods and apparatus are also described for delivering therapeutic agents using collapsible, resorbable balloons. The balloons may be nested and filled with various therapeutic agents that are released over time at rates dependent upon structures and degradation rates of the balloons. Furthermore, the function of the hollow devices can encompass both encapsulation and therapeutic substance delivery roles simultaneously.
摘要翻译： 描述了一种制造可再吸收球囊的方法，该球囊被设计用于容纳用于椎体成形术或椎体后凸成形术的骨粘固剂。 可再吸收的球囊可以在椎体空洞后插入椎体中并填充骨水泥。 气球保持在椎体内的位置，随着时间的推移再次吸收。 还描述了使用可折叠，可再吸收气囊输送治疗剂的方法和装置。 气球可以嵌套并填充随着时间的流逝释放的各种治疗剂，其取决于气囊的结构和降解速率。 此外，中空装置的功能可以同时包含包封和治疗物质递送作用。
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3.发明授权Methods of using adipose derived regenerative cells to promote restoration of intevertebral disc 有权使用脂肪来源的再生细胞促进椎间盘恢复的方法公开(公告)号：US09504716B2
公开(公告)日：2016-11-29
申请号：US12853110
申请日：2010-08-09
IPC分类号： C12N5/00 , A61K35/28 , A61L27/38 , A61L27/52 , A61L27/56 , C12N5/0775 , A61L27/18 , A61L27/36 , A61L27/54
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译： 存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。
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4.发明申请CELL CARRIER AND CELL CARRIER CONTAINMENT DEVICES CONTAINING REGENERATIVE CELLS 审中-公开包含再生细胞的细胞载体和细胞载体包含装置公开(公告)号：US20130060338A1
公开(公告)日：2013-03-07
申请号：US13598203
申请日：2012-08-29
IPC分类号： A61F2/44
CPC分类号： A61K35/32 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2002/30062 , A61F2002/30075 , A61F2002/30133 , A61F2002/30448 , A61F2002/30604 , A61F2002/30841 , A61F2002/30879 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2210/0004 , A61F2210/0061 , A61F2220/005 , A61F2230/0015 , A61K9/0019 , A61K35/28 , B33Y80/00 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： The present invention relates to a device comprising a cell carrier portion containing regenerative cells, e.g., stem and progenitor cells, and a cell carrier containment portion. The device is useful for the treatment of bone related disorders, including spinal fusion related disorders and long bone or flat bone related defects. The device may be used in conjunction with disclosed automated systems and methods for separating and concentrating regenerative cells.
摘要翻译： 本发明涉及包含含有再生细胞例如干细胞和祖细胞的细胞载体部分和细胞载体封闭部分的装置。 该装置可用于治疗骨相关疾病，包括脊柱融合相关疾病和长骨或平骨相关缺陷。 该装置可以与公开的用于分离和集中再生细胞的自动化系统和方法结合使用。
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5.发明授权Methods of using regenerative cells in the treatment of musculoskeletal disorders 有权使用再生细胞治疗肌肉骨骼疾病的方法公开(公告)号：US07771716B2
公开(公告)日：2010-08-10
申请号：US10884637
申请日：2004-07-01
IPC分类号： A01N63/00
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译： 存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。
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6.发明申请RESORBABLE HOLLOW DEVICES FOR IMPLANTATION AND DELIVERY OF THERAPEUTIC AGENTS 审中-公开用于植入和输送治疗药物的可分离的中空装置公开(公告)号：US20100065989A1
公开(公告)日：2010-03-18
申请号：US12624217
申请日：2009-11-23
IPC分类号： B29C49/64
CPC分类号： A61B17/7097 , A61B17/8833 , A61B17/8855 , A61B2017/00004 , A61B2017/8813 , A61B2017/883 , A61F2/44 , A61F2/4601 , A61F2002/30062 , A61F2002/30064 , A61M25/10 , A61M25/1029 , A61M31/002 , A61M2025/0057 , A61M2025/105
摘要： A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. Methods and apparatus are also described for delivering therapeutic agents using collapsible, resorbable balloons. The balloons may be nested and filled with various therapeutic agents that are released over time at rates dependent upon structures and degradation rates of the balloons. Furthermore, the function of the hollow devices can encompass both encapsulation and therapeutic substance delivery roles simultaneously.
摘要翻译： 描述了一种制造可再吸收球囊的方法，该球囊被设计用于容纳用于椎体成形术或椎体后凸成形术的骨粘固剂。 可再吸收的球囊可以在椎体空洞后插入椎体中并填充骨水泥。 气球保持在椎体内的位置，随着时间的推移再次吸收。 还描述了使用可折叠，可再吸收气囊输送治疗剂的方法和装置。 气球可以嵌套并填充随着时间的流逝释放的各种治疗剂，其取决于气囊的结构和降解速率。 此外，中空装置的功能可以同时包含包封和治疗物质递送作用。
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公开(公告)号：US09662152B2
公开(公告)日：2017-05-30
申请号：US12424140
申请日：2009-04-15
IPC分类号： A61F2/44 , A61B17/70 , A61M25/10 , A61M31/00 , A61F2/46 , A61F2/30 , A61B17/88 , A61B17/00 , A61M25/00
CPC分类号： A61B17/7097 , A61B17/8833 , A61B17/8855 , A61B2017/00004 , A61B2017/8813 , A61B2017/883 , A61F2/44 , A61F2/4601 , A61F2002/30062 , A61F2002/30064 , A61M25/10 , A61M25/1029 , A61M31/002 , A61M2025/0057 , A61M2025/105
摘要： A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. Methods and apparatus are also described for delivering therapeutic agents using collapsible, resorbable balloons. The balloons may be nested and filled with various therapeutic agents that are released over time at rates dependent upon structures and degradation rates of the balloons. Furthermore, the function of the hollow devices can encompass both encapsulation and therapeutic substance delivery roles simultaneously.
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8.发明申请CELL CARRIER AND CELL CARRIER CONTAINMENT DEVICES CONTAINING REGENERATIVE CELLS 审中-公开包含再生细胞的细胞载体和细胞载体包含装置公开(公告)号：US20100015204A1
公开(公告)日：2010-01-21
申请号：US12568533
申请日：2009-09-28
CPC分类号： A61K35/32 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2002/30062 , A61F2002/30075 , A61F2002/30133 , A61F2002/30448 , A61F2002/30604 , A61F2002/30841 , A61F2002/30879 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2210/0004 , A61F2210/0061 , A61F2220/005 , A61F2230/0015 , A61K9/0019 , A61K35/28 , B33Y80/00 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： The present invention relates to a device comprising a cell carrier portion containing regenerative cells, e.g. stem and progenitor cells, and a cell carrier containment portion. The device is useful for the treatment of bone related disorders, including spinal fusion related disorders and long bone or flat bone related defects. The device may be used in conjunction with disclosed automated systems and methods for separating and concentrating regenerative cells.
摘要翻译： 本发明涉及一种装置，包括一个包含再生细胞的细胞载体部分， 干细胞和祖细胞，以及细胞载体容纳部分。 该装置可用于治疗骨相关疾病，包括脊柱融合相关疾病和长骨或平骨相关缺陷。 该装置可以与公开的用于分离和集中再生细胞的自动化系统和方法结合使用。
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公开(公告)号：US07595043B2
公开(公告)日：2009-09-29
申请号：US10885293
申请日：2004-07-01
IPC分类号： A01N63/00
CPC分类号： A61K35/32 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2002/30062 , A61F2002/30075 , A61F2002/30133 , A61F2002/30448 , A61F2002/30604 , A61F2002/30841 , A61F2002/30879 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2210/0004 , A61F2210/0061 , A61F2220/005 , A61F2230/0015 , A61K9/0019 , A61K35/28 , B33Y80/00 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： The present invention relates to a device comprising a cell carrier portion containing regenerative cells, e.g., stem and progenitor cells, and a cell carrier containment portion. The device is useful for the treatment of bone related disorders, including spinal fusion related disorders and long bone or flat bone related defects. The device may be used in conjunction with disclosed automated systems and methods for separating and concentrating regenerative cells.
摘要翻译： 本发明涉及包含含有再生细胞例如干细胞和祖细胞的细胞载体部分和细胞载体封闭部分的装置。 该装置可用于治疗骨相关疾病，包括脊柱融合相关疾病和长骨或平骨相关缺陷。 该装置可以与公开的用于分离和集中再生细胞的自动化系统和方法结合使用。
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