公开(公告)号：US20070287691A1

公开(公告)日：2007-12-13

申请号：US11781520

申请日：2007-07-23

申请人： Tadashi HASE ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

发明人： Tadashi HASE ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

IPC分类号： A61K31/231 ,  A61K31/575 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/575 ,  A61K31/231

摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.

摘要翻译： 公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。 还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。 二酰基甘油的摄入导致脂肪酸在小肠中的积累。 如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。 这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。 此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

公开(公告)号：US07056949B2

公开(公告)日：2006-06-06

申请号：US10343742

申请日：2001-08-07

申请人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase

发明人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase

IPC分类号： A61K31/22 ,  A61K31/20 ,  C11B5/00 ,  A23D7/00 ,  A23D9/013

CPC分类号： A23G1/36 ,  A21D2/16 ,  A21D2/165 ,  A23D9/00 ,  A23D9/013 ,  A23G3/40 ,  A23G9/327 ,  A23K20/158 ,  A23L7/111 ,  A23L13/428 ,  A23L13/43 ,  A23L13/60 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23V2002/00 ,  A61K45/06 ,  C11C3/02 ,  C11C3/06 ,  A23V2250/1882 ,  A23V2250/2136 ,  A23V2250/6422 ,  A23V2250/642 ,  A23V2250/032 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/194 ,  A23V2250/5108 ,  A23V2250/1874 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/5118 ,  A23V2250/54246 ,  A23V2250/628

摘要： An oil/fat composition comprising 5 to 99.9 wt. % of a monoglyccride having, as fatty acid constituents thereof, 15 to 90 wt % of an ω 3-unsaturated fatty acid having less than 20 carbon atoms, 1 to 80 wt. % of an ω 9-unsaturated fatty acid and 2 to 50 wt. % of an ω 9-unsaturated fatty acid; and 0.1 to 49.9 wt. % of a diglyceride, wherein a weight ratio of the diglyceride to the monoglyceride is less than 1 and the content of a polyunsaturated fatty acid having at least 4 carbon-to-carbon double bonds is 20% or less in all the fatty acid constituents. The oil/fat composition according to the present invention has excellent processing properties, good taste and excellent lowering action against glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in blood. It is useful not only for pharmaceuticals but also for preventive or remedial foods of feeds effective for hepatic function disturbances or obesity.

摘要翻译： 一种油/脂肪组合物，其包含5至99.9wt。 作为其脂肪酸组分，具有少于20个碳原子的ω-3-不饱和脂肪酸为15〜90重量％，1〜80重量％ ％的不饱和脂肪酸和2〜50重量％ ％的不饱和脂肪酸的％; 和0.1〜49.9wt。 甘油二酯的百分比，其中甘油二酯与单酸甘油酯的重量比小于1，并且在所有脂肪酸组分中具有至少4个碳 - 碳双键的多不饱和脂肪酸的含量为20％以下。 根据本发明的油/脂肪组合物具有优异的加工性能，良好的味道和对谷氨酸草酰乙酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT）水平的降低作用。 它不仅用于药物，而且对于有用于肝功能障碍或肥胖的饲料的预防或补救食物是有用的。

公开(公告)号：US07090886B2

公开(公告)日：2006-08-15

申请号：US10343748

申请日：2001-08-07

申请人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

发明人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

IPC分类号： A23D9/007

CPC分类号： A23G3/40 ,  A21D2/16 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23G3/346 ,  A23G2200/08 ,  A23K20/158 ,  A23L27/60 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  C11B5/0092 ,  C11C1/04 ,  C11C3/02 ,  C11C3/06 ,  A23V2250/182 ,  A23V2250/194 ,  A23V2250/1874 ,  A23V2250/188 ,  A23V2250/1882

摘要： Abstract Provided is an oil/fat composition comprising 60 to 100 wt. % of a diglyceride wherein the diglyceride has, as the fatty acid constituent thereof, 15 to 90 wt. % of an ω 3-unsaturated fatty acid having less than 20 carbon atoms and a cis ω 3-unsaturated fatty acid/(cis ω 6-unsaturated fatty acid+saturated fatty acid+trans unsaturated fatty acid) at a weight ratio of 1 to 6. The composition is excellent in visceral fat burning property, body fat burning property and stability against autoxidation.

摘要翻译： 提供一种油/脂肪组合物，其包含60至100重量％ 甘油二酯的百分比，其中甘油二酯作为其脂肪酸组分具有15至90重量％ ％的少于20个碳原子的ω-3-不饱和脂肪酸和顺式ω3-不饱和脂肪酸/（顺式ω6-不饱和脂肪酸+饱和脂肪酸+反式不饱和脂肪酸）的重量比为1〜 6.内脏脂肪燃烧性能，身体脂肪燃烧性能和抗氧化稳定性优良。

公开(公告)号：US20050148666A1

公开(公告)日：2005-07-07

申请号：US11054557

申请日：2005-02-10

申请人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

发明人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

IPC分类号： A61K31/231 ,  A61K31/225

CPC分类号： A61K31/575 ,  A61K31/231

摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.

摘要翻译： 公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。 还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。 二酰基甘油的摄入导致脂肪酸在小肠中的积累。 如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。 这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。 此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

公开(公告)号：US5126434A

公开(公告)日：1992-06-30

申请号：US561762

申请日：1990-08-02

申请人： Toshiaki Osawa ,  Tadashi Hase ,  Naonobu Yoshizuka

发明人： Toshiaki Osawa ,  Tadashi Hase ,  Naonobu Yoshizuka

IPC分类号： G01N33/53 ,  A61K39/395 ,  C07K16/24 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

CPC分类号： C07K16/24

摘要： The present invention relates to a monoclonal antibody which specifically binds to a peptide having amino acid sequence (I) described below or having in part at least continuous 4 amino acid sequences of the amino acid sequence (I), and also to a process for producing a monoclonal antibody capable of specifically binding to the peptide represented by the following amino acid sequence:H-Y-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH (I)wherein X represents Glu or Gln and Y represents Trp or Arg.

公开(公告)号：US07008661B2

公开(公告)日：2006-03-07

申请号：US10343831

申请日：2001-08-07

申请人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

发明人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

IPC分类号： A23D9/007

CPC分类号： A21D13/068 ,  A21D2/16 ,  A21D13/02 ,  A21D13/80 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23K20/158 ,  A23L15/20 ,  A23L27/60 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/232 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/1882 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/194 ,  A23V2250/5108 ,  A23V2250/1874 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/5118 ,  A23V2250/54246

摘要： Provided is an oil/fat composition comprising 10.1 to 94.9 wt. % of a triglyceride, 0.1 to 30 wt. % of a monoglyceride and 5 to 59.9 wt. % of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt. % of an ω3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.

公开(公告)号：US20050256190A1

公开(公告)日：2005-11-17

申请号：US11185813

申请日：2005-07-21

申请人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

发明人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

IPC分类号： A61K31/231 ,  A61K31/225

CPC分类号： A61K31/575 ,  A61K31/231

摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to α-cumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.

摘要翻译： 公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。 还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。 二酰基甘油的摄取导致小肠中脂肪酸的α-累积。 如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。 这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。 此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

公开(公告)号：US06956058B2

公开(公告)日：2005-10-18

申请号：US10238720

申请日：2002-09-11

申请人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

发明人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

IPC分类号： A61K31/231 ,  A61K31/225

CPC分类号： A61K31/575 ,  A61K31/231

摘要： Methods are disclosed for improving insulin resistance in a diabetic comprising administering a diacylglycerol.

摘要翻译： 公开了改善糖尿病患者胰岛素抵抗的方法，包括给予二酰基甘油。

公开(公告)号：US20050137258A1

公开(公告)日：2005-06-23

申请号：US11054319

申请日：2005-02-10

申请人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

发明人： Tadashi Hase ,  Takatoshi Murase ,  Hiroyuki Watanabe ,  Hidehiko Kondo

IPC分类号： A61K31/231 ,  A61K31/225

CPC分类号： A61K31/575 ,  A61K31/231

摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.

公开(公告)号：US06844021B2

公开(公告)日：2005-01-18

申请号：US10132504

申请日：2002-04-26

申请人： Shin Koike ,  Takatoshi Murase ,  Tadashi Hase

发明人： Shin Koike ,  Takatoshi Murase ,  Tadashi Hase

IPC分类号： A21D2/14 ,  A21D2/16 ,  A21D13/00 ,  A23D7/01 ,  A23D9/007 ,  A23K1/16 ,  A23L1/30 ,  A23L1/302 ,  A23L1/307 ,  A61K31/231 ,  A61K31/575 ,  A61P3/04 ,  C11B5/00 ,  C11C3/00 ,  A61K31/202

CPC分类号： A23D7/011 ,  A23K20/158 ,  A23L33/105 ,  A23L33/11 ,  A23L33/12 ,  A23L33/15 ,  A23V2002/00 ,  Y10S514/909 ,  A23V2250/1882 ,  A23V2250/1868 ,  A23V2250/1874 ,  A23V2250/187

摘要： The oil or fat composition of the invention contains a monoacylglycerol and/or a diacylglycerol in a total amount of 5-100 wt. % and which exhibits an index of stability against oxidation (induction time as measured through a Rancimat test conducted at 100° C.) of 7 or higher, wherein the monoacylglycerol and/or the diacylglycerol contain, as fatty acid constituents, ω3 unsaturated fatty acids in amounts of 15-90 wt. %. Through ingestion thereof in a small amount without drastically changing the person's lifestyle, the highly harmless oil/fat composition of the present invention provides effects for reducing and preventing accumulation of body fat, for reducing and preventing accumulation of visceral fat, and for prevention and treatment of obesity; and exerts an excellent prevention and treatment effect on life-style related diseases through long-term ingestion. Thus, the composition of the present invention is useful for foods, pharmaceuticals and pet food or feed.

摘要翻译： 本发明的油脂组合物含有总量为5-100重量％的单酰基甘油和/或二酰基甘油。 ％，其表现出对氧化的稳定性指标（通过在100℃下进行的Rancimat测试的诱导时间）为7或更高，其中单酰基甘油和/或二酰基甘油含有作为脂肪酸成分的ω3不饱和脂肪酸 用量为15-90wt。 ％ 通过摄取少量而不会剧烈改变人的生活方式，本发明的高度无害的油/脂肪组合物提供了降低和防止体脂堆积，减少和防止内脏脂肪累积以及预防和治疗的效果 的肥胖; 通过长期摄入对生活方式相关疾病具有极好的预防和治疗效果。 因此，本发明的组合物可用于食品，药品和宠物食品或饲料。