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    System and method of controlling fluid temperature for improving injectivity of supercritical carbon dioxide into stratum
    1.
    发明授权
    System and method of controlling fluid temperature for improving injectivity of supercritical carbon dioxide into stratum 有权
    控制流体温度的系统和方法，以提高超临界二氧化碳向地层的注入

    公开(公告)号：US09074456B2

    公开(公告)日：2015-07-07

    申请号：US13289803

    申请日：2011-11-04

    申请人： Kue-Young Kim ,  Taehee Kim ,  Jeong-Chan Kim

    发明人： Kue-Young Kim ,  Taehee Kim ,  Jeong-Chan Kim

    IPC分类号： E21B36/04 ,  E21B36/00 ,  E21B41/00

    CPC分类号： E21B41/0064 ,  E21B36/04 ,  Y02C10/14

    摘要： A system and a method of controlling a fluid temperature for improving injectivity of a supercritical carbon dioxide into a stratum includes a casing part installed in a well, which is formed from a ground surface to a target stratum for injection, a grouting part formed between the casing part and a counterforted wall of the well, a cover covering an upper portion of the casing part, an injection tube inserted into the casing part through the cover and receiving the carbon dioxide injected into the injection tube, a perforation part serving as a passage allowing the carbon dioxide to flow from the injection tube to the target stratum, a packing part formed between the injection tube and an inner portion of the casing part, a heat coil part surrounding the injection tube, and a temperature adjusting unit controlling a temperature of the heat coil part.

    摘要翻译： 控制流体温度以提高超临界二氧化碳向地层注入的系统和方法包括：安装在井中的壳体部分，其由地表到目标喷射层形成;灌浆部分 壳体部分和井的反渗透壁，覆盖壳体部分的上部的盖，通过盖插入壳体部分并接收注入到喷射管中的二氧化碳的喷射管，用作通道的穿孔部分 允许二氧化碳从注射管流到目标层，形成在注射管和壳体部分的内部之间的填充部分，围绕注射管的热线圈部分和控制温度的温度调节单元 热线圈部分。

    Sustained-release liposomal anesthetic compositions
    3.
    发明申请
    Sustained-release liposomal anesthetic compositions 有权
    持续释放脂质体麻醉剂组合物

    公开(公告)号：US20060078606A1

    公开(公告)日：2006-04-13

    申请号：US11097756

    申请日：2005-04-01

    申请人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    发明人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1277 ,  A61K9/0002 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12

    摘要： The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.

    摘要翻译： 本发明提供一种用于获得包封在脂质体中的局部麻醉剂的方法，例如多泡脂质体，具有高的包封效率和体内缓释。 当胶囊麻醉剂作为单次皮内剂量施用时，与未包封的麻醉剂的注射相比，在局部注射部位的药物的麻醉持续时间和半衰期增加。 包封的麻醉剂的最大耐受剂量在注射未包封的麻醉剂时在脂质体制剂中也显着增加。 这些结果表明，局部麻醉剂的脂质体制剂可用于持续局部浸润和神经阻滞麻醉。

    Sustained-release liposomal anesthetic compositions
    5.
    发明授权
    Sustained-release liposomal anesthetic compositions 有权
    持续释放脂质体麻醉剂组合物

    公开(公告)号：US08834921B2

    公开(公告)日：2014-09-16

    申请号：US13476823

    申请日：2012-05-21

    申请人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    发明人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K47/12 ,  A61K47/02 ,  A61K31/40 ,  A61K31/445 ,  A61K31/167

    CPC分类号： A61K9/1277 ,  A61K9/0002 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12

    摘要： The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.

    摘要翻译： 本发明提供了一种用于获得包封在脂质体中的局部麻醉剂的方法，例如多囊泡脂质体，具有高的包封效率和体内缓释。 当胶囊麻醉剂作为单次皮内剂量施用时，与未包封的麻醉剂的注射相比，在局部注射部位的药物的麻醉持续时间和半衰期增加。 包封的麻醉剂的最大耐受剂量在注射未包封的麻醉剂时在脂质体制剂中也显着增加。 这些结果表明，局部麻醉剂的脂质体制剂可用于持续局部浸润和神经阻滞麻醉。

    SUSTAINED-RELEASE LIPOSOMAL ANESTHETIC COMPOSITIONS
    6.
    发明申请
    SUSTAINED-RELEASE LIPOSOMAL ANESTHETIC COMPOSITIONS 有权
    持续释放脂肪组织

    公开(公告)号：US20120231070A1

    公开(公告)日：2012-09-13

    申请号：US13476823

    申请日：2012-05-21

    申请人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    发明人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    IPC分类号： A61K9/127 ,  A61K31/40 ,  A61K31/165 ,  A61K31/445

    CPC分类号： A61K9/1277 ,  A61K9/0002 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12

    摘要： The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.

    摘要翻译： 本发明提供了一种用于获得包封在脂质体中的局部麻醉剂的方法，例如多囊泡脂质体，具有高的包封效率和体内缓释。 当胶囊麻醉剂作为单次皮内剂量施用时，与未包封的麻醉剂的注射相比，在局部注射部位的药物的麻醉持续时间和半衰期增加。 包封的麻醉剂的最大耐受剂量在注射未包封的麻醉剂时在脂质体制剂中也显着增加。 这些结果表明，局部麻醉剂的脂质体制剂可用于持续局部浸润和神经阻滞麻醉。

    Sustained-release liposomal anesthetic compositions
    8.
    发明授权
    Sustained-release liposomal anesthetic compositions 有权
    持续释放脂质体麻醉剂组合物

    公开(公告)号：US6045824A

    公开(公告)日：2000-04-04

    申请号：US156214

    申请日：1998-09-18

    申请人： Sinil Kim ,  Taehee Kim ,  Sharad Murdandi

    发明人： Sinil Kim ,  Taehee Kim ,  Sharad Murdandi

    IPC分类号： F04C18/02 ,  A61K9/127 ,  A61K31/16 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61P23/02

    CPC分类号： A61K9/1277 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12 ,  A61K9/0002 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1271

    摘要： The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is usefuil for sustained local infiltration and nerve block anesthesia.

    摘要翻译： 本发明提供一种用于获得包封在脂质体中的局部麻醉剂的方法，例如多泡脂质体，具有高的包封效率和体内缓释。 当胶囊麻醉剂作为单次皮内剂量施用时，与未包封的麻醉剂的注射相比，在局部注射部位的药物的麻醉持续时间和半衰期增加。 包封的麻醉剂的最大耐受剂量在注射未包封的麻醉剂时在脂质体制剂中也显着增加。 这些结果表明，局部麻醉剂的脂质体制剂是用于持续局部浸润和神经阻滞麻醉的用途。

    Sustained-release liposomal anesthetic compositions
    10.
    发明授权
    Sustained-release liposomal anesthetic compositions 有权
    持续释放脂质体麻醉剂组合物

    公开(公告)号：US08182835B2

    公开(公告)日：2012-05-22

    申请号：US11097756

    申请日：2005-04-01

    申请人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    发明人： Sinil Kim ,  Taehee Kim ,  Sharad Murdande

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1277 ,  A61K9/0002 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12

    摘要： The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is useful for sustained local infiltration and nerve block anesthesia.

    摘要翻译： 本发明提供一种用于获得包封在脂质体中的局部麻醉剂的方法，例如多泡脂质体，具有高的包封效率和体内缓释。 当胶囊麻醉剂作为单次皮内剂量施用时，与未包封的麻醉剂的注射相比，在局部注射部位的药物的麻醉持续时间和半衰期增加。 包封的麻醉剂的最大耐受剂量在注射未包封的麻醉剂时在脂质体制剂中也显着增加。 这些结果表明，局部麻醉剂的脂质体制剂可用于持续局部浸润和神经阻滞麻醉。