公开(公告)号：US20070275888A1

公开(公告)日：2007-11-29

申请号：US10584183

申请日：2004-12-24

申请人： Eiji Sunahara ,  Takafumi Ishii

发明人： Eiji Sunahara ,  Takafumi Ishii

IPC分类号： A61K38/55 ,  C07K14/705 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06

CPC分类号： G01N33/574 ,  C07K14/47 ,  G01N2333/47

摘要： The present invention provides a substance that inhibits the binding of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7 or SEQ ID NO: 10, its partial peptide or a salt thereof, to a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 26, its partial peptide or a salt thereof; an agent for preventing/treating cancer, etc., an agent for promoting apoptosis in cancer cells, an agent for inhibiting cancer cell growth, and so on, which comprises the substance described above.

摘要翻译： 本发明提供抑制包含与SEQ ID NO：1，SEQ ID NO：4，SEQ ID NO：7或SEQ ID NO：7所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合的物质 NO：10，其部分肽或其盐与包含与SEQ ID NO：26所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质，其部分肽或其盐; 用于预防/治疗癌症的药剂等，用于促进癌细胞凋亡的药剂，抑制癌细胞生长的药剂等，其包含上述物质。

公开(公告)号：US20050204514A1

公开(公告)日：2005-09-22

申请号：US11076948

申请日：2005-03-11

申请人： Yukichi Takamatsu ,  Koji Kiriyama ,  Akira Asano ,  Takafumi Ishii

发明人： Yukichi Takamatsu ,  Koji Kiriyama ,  Akira Asano ,  Takafumi Ishii

IPC分类号： C01B13/20 ,  C01F7/34 ,  C01G1/00 ,  C01G1/02 ,  C01G23/00 ,  C01G29/00 ,  C01G33/00 ,  C01G35/00

CPC分类号： C01G1/02 ,  C01B13/20 ,  C01G23/003 ,  C01G23/006 ,  C01G29/00 ,  C01G33/00 ,  C01G35/00 ,  Y10S502/525

摘要： An apparatus for producing powders of metal compound containing oxygen comprising a liquid flow controller, a vaporizer and a reactor, which consists essentially of: means for feeding a gas containing a material and oxygen; means for heating the gas from the side surface of the feeding means; means for cooling the gas positioned at the downstream side of the feeding means; and means for receiving the product generated by the reaction. A process and products for producing powders of metal compound containing oxygen comprising the steps of: feeding at least one material selected from a liquid material and a solution material obtained by dissolving solid ingredient in organic solvent via a liquid flow controller into a vaporizer; vaporizing the materials in the vaporizer; adding oxygen; heating; cooling; and crystallizing. The process and the apparatus enable easily mass-producing fine powders of metal compound containing oxygen used as materials for optical crystals, nonlinear crystals or magneto-optical crystals with reasonable production cost.

摘要翻译： 一种用于生产包含氧的金属化合物的粉末的装置，包括液体流量控制器，蒸发器和反应器，其基本上由以下部件组成：用于供给包含材料和氧气的气体的装置; 用于从进料装置的侧表面加热气体的装置; 用于冷却位于所述进给装置的下游侧的气体的装置; 以及用于接收由反应产生的产物的装置。 一种用于生产含氧的金属化合物粉末的方法和产品，包括以下步骤：将通过液体流量控制器将固体成分溶解在有机溶剂中而获得的液体材料和溶液中的至少一种材料进料到蒸发器中; 蒸发蒸发器中的物质; 加氧; 加热; 冷却; 并结晶。 该方法和装置能够以合理的生产成本容易地批量生产含有氧的金属化合物的细粉末作为光学晶体的材料，非线性晶体或磁光晶体。

公开(公告)号：US5288426A

公开(公告)日：1994-02-22

申请号：US601026

申请日：1990-10-23

申请人： Hiroyuki Itoh ,  Takafumi Ishii ,  Takehiro Toyooka ,  Tetsuo Satoh

发明人： Hiroyuki Itoh ,  Takafumi Ishii ,  Takehiro Toyooka ,  Tetsuo Satoh

IPC分类号： C09K19/38 ,  G02F1/361 ,  C09K19/54 ,  C09K19/52 ,  F21V9/00 ,  G02F1/13

CPC分类号： C09K19/3809 ,  G02F1/361 ,  G02F1/3616

摘要： A nonlinear optical material having a high nonlinear optical constant useful for frequency doubler of laser beam which comprises a chiral smectic C liquid crystalline polyester consisting essentially of the structural units having the general formulae (A), (B) and (C); ##STR1## Wherein X is a structural unit selected from the group consisting of ##STR2## Wherein Y is a group having at least one optically active carbon and the total carbon number of Y is 3-12. ##STR3## wherein n is an integer of 2-10.

摘要翻译： 具有用于激光束倍频器的高非线性光学常数的非线性光学材料，其包括基本上由具有通式（A），（B）和（C）的结构单元组成的手性近晶C液晶聚酯; （*化学结构*）其中X是选自（*化学结构*）（*化学结构*）（*化学结构*）（*化学结构*）（*化学结构*）（* 化学结构*）（*化学结构*）（*化学结构*）（B）+ BL，4 -OYO- + BL，4444 1-60摩尔％其中Y是具有至少一个 光学活性碳，Y的总碳数为3-12。 （*化学结构*）其中n为2-10的整数。

公开(公告)号：US5097016A

公开(公告)日：1992-03-17

申请号：US334594

申请日：1989-04-06

申请人： Takafumi Ishii ,  Takehiro Toyooka ,  Shigeki Iida ,  Tomohiro Toya ,  Itoh Hiroyuki ,  Hajime Hara ,  Satoh Tetsuo

发明人： Takafumi Ishii ,  Takehiro Toyooka ,  Shigeki Iida ,  Tomohiro Toya ,  Itoh Hiroyuki ,  Hajime Hara ,  Satoh Tetsuo

IPC分类号： C09K19/38 ,  C09K19/54 ,  G02F1/361

CPC分类号： G02F1/3615 ,  C09K19/389 ,  C09K19/54

摘要： A nonlinear optical material obtained by blending 50-99% by weigth of a polypeptide and 1-50% by weight of a compound exerting a nonlinear optical response has a very large nonlinear optical constant, exterts a high and stable SHG activity and easily undergoes phase matching.

公开(公告)号：US08860430B2

公开(公告)日：2014-10-14

申请号：US13379515

申请日：2010-05-18

申请人： Takafumi Ishii ,  Masanobu Yoshidomi

发明人： Takafumi Ishii ,  Masanobu Yoshidomi

IPC分类号： G01R31/02 ,  G01R27/18 ,  G01R27/02 ,  G01R31/14

CPC分类号： G01R27/025 ,  G01R27/18 ,  G01R31/025 ,  G01R31/14

摘要： An object is to detect an insulation failure of a DC circuit with high sensitivity and in safety by means of a simple detection circuit. An insulation resistance measurement device of this invention is a device for measuring an insulation resistance to ground of a DC source circuit and is provided with connection terminals for connections to a positive electrode and a negative electrode of a series power supply, switch elements connected between the connection terminals and the ground potential and configured to switch connections between the connection terminals and the ground potential, resistive elements connected through the switch elements between the connection terminals respectively, and the ground potential, and a voltage detection unit for detecting voltage drops in the resistive elements.

摘要翻译： 目的是通过简单的检测电路来检测具有高灵敏度和安全性的直流电路的绝缘故障。 本发明的绝缘电阻测量装置是用于测量直流源电路的接地绝缘电阻的装置，并且设置有用于连接到串联电源的正极和负极的连接端子，连接在串联电源 连接端子和地电位，并且被配置为切换连接端子与接地电位之间的连接，分别通过连接端子之间的开关元件连接的电阻元件和接地电位;以及用于检测电阻中的电压降的电压检测单元 元素。

公开(公告)号：US20140225444A1

公开(公告)日：2014-08-14

申请号：US14236423

申请日：2012-07-13

申请人： Masanobu Yoshidomi ,  Takafumi Ishii

发明人： Masanobu Yoshidomi ,  Takafumi Ishii

IPC分类号： G01R31/02 ,  H02J1/00 ,  G01R31/40

CPC分类号： G01R31/025 ,  H01L31/02021 ,  H02H3/16 ,  H02J1/00 ,  H02S50/00 ,  H02S50/10 ,  Y02E10/50 ,  Y10T307/691

摘要： In a ground fault detection device, two photovoltaic strings are disconnected from a photovoltaic power generation system, a measurement of a first voltage value is performed for the one photovoltaic string by a first measurement unit, and in parallel therewith, a measurement of a second voltage value is performed for the other photovoltaic string by the second measurement unit by executing various functions of a calculation control unit. Thus, a capacitance relative to a ground of a measurement target is reduced. Further, the photovoltaic string is electrically separated from a load device at the time of such a measurement. Further, separate measurements are performed on the one and other photovoltaic strings in the disconnected state, and the first and second voltage values are measured in parallel.

摘要翻译： 在接地故障检测装置中，从光伏发电系统断开两个光伏电池串，通过第一测量单元对一个光伏电池串执行第一电压值的测量，并且与之并行地测量第二电压 通过执行计算控制单元的各种功能，由第二测量单元为另一光伏串执行值。 因此，相对于测量对象的接地的电容减小。 此外，在这种测量时，光伏串与负载装置电气分离。 此外，在断开状态下对一个和其它光伏电池串进行单独的测量，并且测量第一和第二电压值。

公开(公告)号：US07723496B2

公开(公告)日：2010-05-25

申请号：US10525105

申请日：2003-08-20

申请人： Takafumi Ishii ,  Koji Yamamoto ,  Eiji Sunahara ,  Shuji Sato

发明人： Takafumi Ishii ,  Koji Yamamoto ,  Eiji Sunahara ,  Shuji Sato

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12P15/00

CPC分类号： A61K45/06 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/47 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  A61K2300/00

摘要： A compound inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 10, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 25 or SEQ ID NO: 27, or a salt thereof; a compound inhibiting the expression of a gene of the protein; an antisense polynucleotide containing the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding the protein or its partial peptide; an antibody to the protein or its partial peptide, etc. are useful as prophylactic/therapeutic agents for cancer, etc., apoptosis promoters for cancer cells, and the like.

摘要翻译： 抑制蛋白质活性的化合物，其包含与SEQ ID NO：1，SEQ ID NO：4，SEQ ID NO：7，SEQ ID NO：10，SEQ ID NO：10所示的氨基酸序列相同或基本相同的氨基酸序列 SEQ ID NO：17，SEQ ID NO：20，SEQ ID NO：22，SEQ ID NO：25或SEQ ID NO：27，或其盐; 抑制蛋白质基因表达的化合物; 含有与编码该蛋白质或其部分肽的多核苷酸的碱基序列互补或基本上互补的全部或部分碱基序列的反义多核苷酸; 对蛋白质或其部分肽的抗体等可用作癌症等的预防/治疗剂，癌细胞的凋亡启动子等。

公开(公告)号：US20090142345A1

公开(公告)日：2009-06-04

申请号：US11908675

申请日：2005-03-14

申请人： Shuji Satou ,  Takafumi Ishii

发明人： Shuji Satou ,  Takafumi Ishii

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/00

CPC分类号： C07K16/2851 ,  C07K16/30 ,  C07K2317/73 ,  C07K2317/76

摘要： The present invention provides a safe drug that targets a molecule specifically expressed in cancer cells, and that induces cancer cell growth inhibition. More specifically, the present invention provides a neutralizing antibody against a protein comprising the same or substantially the same amino acid sequence as that shown by SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7 or SEQ ID NO:9, or a partial peptide thereof or a salt thereof, and a prophylactic/therapeutic agent for cancers (for example, breast cancer, ovarian cancer, colorectal cancer, lung cancer, pancreatic cancer) and the like, apoptosis promoter, cancer cell growth suppressant, DDR1 antagonist and the like, comprising the neutralizing antibody.

摘要翻译： 本发明提供了靶向在癌细胞中特异性表达的分子并且诱导癌细胞生长抑制的安全药物。 更具体地，本发明提供了针对蛋白质的中和抗体，其包含与SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：7所示相同或基本相同的氨基酸序列 或其部分肽或其盐，以及癌症的预防/治疗剂（例如乳腺癌，卵巢癌，结肠直肠癌，肺癌，胰腺癌）等，凋亡启动子 ，癌细胞生长抑制剂，DDR1拮抗剂等，其包含中和抗体。

公开(公告)号：US07489857B2

公开(公告)日：2009-02-10

申请号：US11735732

申请日：2007-04-16

申请人： Yukichi Takamatsu ,  Koji Kiriyama ,  Akira Asano ,  Takafumi Ishii

发明人： Yukichi Takamatsu ,  Koji Kiriyama ,  Akira Asano ,  Takafumi Ishii

IPC分类号： C23C14/00 ,  C23C16/00 ,  B01J10/02

CPC分类号： C01G1/02 ,  C01B13/20 ,  C01G23/003 ,  C01G23/006 ,  C01G29/00 ,  C01G33/00 ,  C01G35/00 ,  Y10S502/525

摘要： An apparatus for producing powders of metal compound containing oxygen comprising a liquid flow controller, a vaporizer and a reactor, which consists essentially of: means for feeding a gas containing a material and oxygen; means for heating the gas from the side surface of the feeding means; means for cooling the gas positioned at the downstream side of the feeding means; and means for receiving the product generated by the reaction. A process and products for producing powders of metal compound containing oxygen comprising the steps of: feeding at least one material selected from a liquid material and a solution material obtained by dissolving solid ingredient in organic solvent via a liquid flow controller into a vaporizer; vaporizing the materials in the vaporizer; adding oxygen; heating; cooling; and crystallizing. The process and the apparatus enable easily mass-producing fine powders of metal compound containing oxygen used as materials for optical crystals, nonlinear crystals or magneto-optical crystals with reasonable production cost.

摘要翻译： 一种用于生产包含氧的金属化合物的粉末的装置，包括液体流量控制器，蒸发器和反应器，其基本上由以下部件组成：用于供给包含材料和氧气的气体的装置; 用于从进料装置的侧表面加热气体的装置; 用于冷却位于所述进给装置的下游侧的气体的装置; 以及用于接收由反应产生的产物的装置。 一种用于生产含氧的金属化合物粉末的方法和产品，包括以下步骤：将通过液体流量控制器将固体成分溶解在有机溶剂中而获得的液体材料和溶液中的至少一种材料进料到蒸发器中; 蒸发蒸发器中的物质; 加氧; 加热; 冷却; 并结晶。 该方法和装置能够以合理的生产成本容易地批量生产含有氧的金属化合物的细粉末作为光学晶体的材料，非线性晶体或磁光晶体。

公开(公告)号：US07297322B2

公开(公告)日：2007-11-20

申请号：US11076948

申请日：2005-03-11

申请人： Yukichi Takamatsu ,  Koji Kiriyama ,  Akira Asano ,  Takafumi Ishii

发明人： Yukichi Takamatsu ,  Koji Kiriyama ,  Akira Asano ,  Takafumi Ishii

IPC分类号： C01G1/00

CPC分类号： C01G1/02 ,  C01B13/20 ,  C01G23/003 ,  C01G23/006 ,  C01G29/00 ,  C01G33/00 ,  C01G35/00 ,  Y10S502/525

摘要： A process for producing powders of metal compound containing oxygen including the steps of: feeding at least one material selected from a liquid material and a solution material obtained by dissolving solid ingredient in organic solvent via a liquid flow controller into a vaporizer; vaporizing the materials in the vaporizer; adding oxygen; heating; cooling; and crystallizing. Also disclosed is the product formed by this process, and apparatus used in performing the process. The process and the apparatus enable easily mass-producing fine powders of metal compound containing oxygen used as materials for optical crystals, nonlinear crystals or magneto-optical crystals with reasonable production cost.

摘要翻译： 一种生产包含氧的金属化合物粉末的方法，包括以下步骤：将通过液体流量控制器将固体成分溶解在有机溶剂中而获得的液体材料和溶液中的至少一种材料进料到蒸发器中; 蒸发蒸发器中的物质; 加氧; 加热; 冷却; 并结晶。 还公开了通过该方法形成的产品以及用于执行该过程的装置。 该方法和装置能够以合理的生产成本容易地批量生产含有氧的金属化合物的细粉末作为光学晶体的材料，非线性晶体或磁光晶体。