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公开(公告)号：US20230133326A1
公开(公告)日：2023-05-04
申请号：US17975595
申请日：2022-10-27
发明人： Mansoor Khan , Ziyaur Rahman , Indra K. Reddy , Satish Dharani
摘要： In an embodiment, the present disclosure pertains to a stable formulation of a primary, secondary, and/or tertiary amino group containing composition that prevents or reduces formation of a nitroso impurity until the end of stated expiration or longer. In some embodiments, the composition includes metformin and at least one pharmaceutical excipient. In some embodiments, the at least one pharmaceutical excipient includes a magnesium salt and at least one of a calcium salt, dicalcium phosphate, polyethylene glycol, or polyethylene oxide. In some embodiments, the magnesium salt can include, without limitation, magnesium aluminum silicate, magnesium aluminometasilicate, magnesium carbonate, magnesium oxide, magnesium silicate, magnesium stearate, magnesium sulfate, magnesium trisilicate, and combinations thereof. In some embodiments, a weight ratio of the drug to the at least one pharmaceutical excipient ranges from 1 to 99 to 99 to 1% w/w. In some embodiments, the at least one pharmaceutical excipient is a protective pharmaceutical ingredient.
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公开(公告)号：US20230121041A1
公开(公告)日：2023-04-20
申请号：US17911609
申请日：2021-03-17
摘要： An apparatus for converting heavy hydrocarbons to light hydrocarbons includes an inlet capable of supplying a pre-foaming mixture comprising a hydrocarbon to be processed and a processing gas, wherein the processing gas is dissolved in the hydrocarbon to be processed; a foam generator configured to receive the pre-foaming mixture at a first pressure, compress the pre-foaming mixture to a second pressure that is higher than the first pressure by routing it through a nozzle; and generate a foam by allowing the pre-foaming mixture at the second pressure to expand in a chamber at a third pressure that is lower than the first or second pressures; a plasma reactor, wherein the plasma reactor is capable of receiving the foam and comprises at least one pair of spark gap electrodes capable of subjecting the foam to a plasma discharge to yield a processed mixture; and an outlet capable of receiving the processed mixture.
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公开(公告)号：US20230085218A1
公开(公告)日：2023-03-16
申请号：US17759244
申请日：2021-01-21
发明人： Virender K. Sharma
摘要： Activated ferrate solutions, methods of their preparation, and methods of disinfecting surfaces and oxidizing pollutants in water are provided.
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公开(公告)号：US20230083257A1
公开(公告)日：2023-03-16
申请号：US17790336
申请日：2020-12-31
发明人： Suresh D. Pillai , David Staack , John Lassalle , Thomas Hoelen , Paul Bireta
IPC分类号： C02F9/00
摘要： A method of waste treatment includes treating partially-dewatered matrix with a first electron-beam radiation dose. The treated partially-dewatered matrix is transferred to a digester where the treated partially-dewatered matrix is subjected to anaerobic digestion. Biogas is recovered from the treated partially-dewatered matrix during the anaerobic digestion. The treated partially-dewatered matrix is dried and subjected to a second electron-beam radiation dose.
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公开(公告)号：US11596530B2
公开(公告)日：2023-03-07
申请号：US16769013
申请日：2018-12-12
发明人： Daniel McGowan , Pilwon Hur
摘要： In an embodiment, a prosthetic leg including a modular knee element coupled to a modular ankle element. The modular knee element includes a knee motor rotatable about an axis of a shaft in the knee motor. The modular ankle element includes a drive portion coupled to a surface-contacting portion via a pylon having a top and bottom end. The top end is coupled to the drive portion and the bottom end is coupled to the surface-contacting portion. The drive portion includes an ankle motor coupled to a rotary series elastic actuator (RSEA) and a first pulley coupled to the RSEA. The surface-contacting portion includes a hinge and a second pulley with a belt engaging at least a portion of at least one of the first and second pulley, and a modular foot element coupled to the bottom of the hinge.
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公开(公告)号：US11585755B2
公开(公告)日：2023-02-21
申请号：US17083365
申请日：2020-10-29
发明人： Minchul Kang
摘要： A system and associated method measures anomalous diffusion of biomolecules in cell membranes of intact cells and includes a laser that illuminates a cell membrane within an intact cell to express fluorescently tagged biomolecules. The laser photobleaches a region of interest and illuminates the region of interest over time. A detector detects the fluorescence recovery over time within the region of interest to yield fluorescence recovery after photobleaching (FRAP) data. A controller computes the mean square displacement (MSD) of diffusing biomolecules and a time-dependent diffusion coefficient D(t) from a plurality of time points of the FRAP data and determines the anomalous diffusion in the cell membrane.
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公开(公告)号：US20230036705A1
公开(公告)日：2023-02-02
申请号：US17787958
申请日：2021-01-29
发明人： Meng-Jie Hsiao , Cam V. Nguyen
摘要： Architectures of millimeter wave fully-integrated frequency-division duplex (FDD) transmitting-receiving (T/R) front-end (FE) modules include a duplexer (DUX), power amplifier (PA), and low noise amplifier (LNA) on a single semiconductor substrate to facilitate the development of system on a chip (SoC) for millimeter wave 5G wireless and next-generation communications applications. The entire balanced DUX module implements TX signals in differential mode, and RX signals in single-ended mode. LNA input is located at the center of a symmetrical plane of the entire FE module, resulting in an inherent ultra-high isolation between the differential PA output ports and the LNA input port across a ultra-wide bandwidth. The DUX can stand alone as a single unit in a system and is used together with external PA and LNA provided in the system, or it can include its own internal PA and LNA to form a DUX FE module.
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公开(公告)号：US11549354B2
公开(公告)日：2023-01-10
申请号：US16294807
申请日：2019-03-06
发明人： Enrique Zarate Losoya , Samuel F. Noynaert , Ibrahim S. El-sayed , Tyrell A. Cunningham , Eduardo Gildin
摘要： In some examples, a method performed by a drilling rig control center, includes receiving raw data for a first time segment, the raw data related to a drilling operation. In addition, the method includes deriving first drilling state measurements based on the raw data of the first time segment. Further, the method includes deriving first formation state measurements based on the raw data of the first time segment. The method also includes correlating the first derived drilling and formation state measurements of the first time segment with a second derived drilling and formation state measurements of a second time segment. Still further, the method includes generating a control response based on the correlation.
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9.发明授权公开(公告)号：US11535703B2
公开(公告)日：2022-12-27
申请号：US17161067
申请日：2021-01-28
发明人： Lei Fang , Zi-Hao Guo , Chenxu Wang , Qiang Zhang , Hong-Cai Zhou
IPC分类号： C08G61/10 , B01J20/26 , B01J20/20 , B01J20/28 , B01J20/30 , B01D15/16 , B01D67/00 , C08G61/12 , B01D71/06 , B01D71/44 , C08G61/02 , C08J9/28 , B01D61/02 , B01D61/14
摘要： The present disclosure relates to synthesis of porous polymer networks and applications of such materials. The present disclosure relates to a method of fabricating of a porous polymer network comprising: (a) providing: (i) a first reactant comprising a plurality of compounds comprising at least one acetyl group, said plurality of compounds comprising at least one compound type, and (ii) a second reactant comprising an alkylsulfonic acid, and (b) creating a solution of said reactants, (c) casting said solution in a form, and (d) treating said solution under such conditions so as to produce a porous polymer network. In one embodiment, the invention relates to a porous polymer network which has a basic structure selected from the group consisting of
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公开(公告)号：US20220402998A1
公开(公告)日：2022-12-22
申请号：US17772539
申请日：2020-10-30
发明人： WENSHE RAY LIU , WENYUE CAO
IPC分类号： C07K14/725 , C07K14/705 , A61K35/17 , A61P35/00 , C12N9/50 , C07K16/28
摘要： The subject invention pertains to a chimeric antigen receptor, a T cell comprising said CAR and methods of making and using said CAR and said T cell for the treatment of a cancer and/or an immune disease. In specific embodiments, the method comprises the use of T cells comprising CARs to target different antigens on target cells. In further specific embodiments, the CARs of the invention comprise NS3 protease domains and cleavage sites, which NS3 domains are inhibited by small molecule inhibitors for customized CAR-T cell therapy.
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