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公开(公告)号：US20220175851A1
公开(公告)日：2022-06-09
申请号：US17437643
申请日：2020-03-13
IPC分类号： A61K35/74 , A61P15/00 , A61P3/02 , A61K31/575 , A61K31/353 , A61K38/18
摘要： Disclosed herein are methods for promoting fetal growth, placental development, and angiogenesis, comprising administering to a female subject or to a maternal subject gestating an unborn baby (e.g., fetus) a composition of the present disclosure. Also disclosed are methods of inhibiting development of a disease or disorder, such as preeclampsia or fetal growth reduction (FGR), in a subject, comprising administering to a female subject or to a maternal subject gestating an unborn baby (e.g., fetus) a composition of the present disclosure.
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公开(公告)号：US20150299279A1
公开(公告)日：2015-10-22
申请号：US14607713
申请日：2015-01-28
发明人： Nazneen Dewji , S. Jonathan Singer
CPC分类号： C07K14/4711 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/1709 , C07K7/06 , C07K7/08
摘要： The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease.
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3.发明申请STENCIL PATTERNING METHODS AND APPARATUS FOR GENERATING HIGHLY UNIFORM STEM CELL COLONIES 审中-公开用于产生高度均匀干细胞群的STENCIL模式方法和装置公开(公告)号：US20130196435A1
公开(公告)日：2013-08-01
申请号：US13738210
申请日：2013-01-10
申请人： THE REGENTS OF THE UNIVERSITY CALIFORNIA , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
CPC分类号： C12M23/34 , C12N5/0068 , C12N5/0657 , C12N2533/90 , C12N2535/10
摘要： A method for producing highly uniform cell colonies in a cell culture dish with the use of stencils made from an elastomeric sheet sized to fit within the cell culture dish, having a singular opening or a plurality of openings of a number, pitch and diameter configured to optimally control the geometric growth parameters of a cell colony. The uniform cell colonies are produced by placing the stencil in a cell culture dish and hydropilizing the stencil. The stencil is overlayed with cell culture media and seeded with seed cells that are preferably grown for at least a day before the stencil is removed to produce a pattern of seeded cells with controlled pitch, colony diameter and density within the culture dish that grow to become highly uniform cell colonies. A kit with culture dish, stencil, culture media and growth media is also provided.
摘要翻译： 一种在细胞培养皿中产生高度均匀的细胞集落的方法，其使用由尺寸适合于细胞培养皿的弹性体片制成的模板，所述模板具有单个开口或多个开口或数个，间距和直径的开口，其被配置为 最佳地控制细胞集落的几何生长参数。 通过将模板放置在细胞培养皿中并将模板加水来制备均匀的细胞集落。 将模板覆盖在细胞培养基上并用种子细胞接种，种子细胞优选在去除模板之前至少一天生长以产生培养皿中培养皿内具有受控间距，菌落直径和密度的接种细胞的图案 高度统一的细胞集落。 还提供了包含培养皿，模板，培养基和成长培养基的试剂盒。
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公开(公告)号：US20170175126A1
公开(公告)日：2017-06-22
申请号：US15382539
申请日：2016-12-16
IPC分类号： C12N15/113 , A01K67/027
CPC分类号： C12N15/1137 , A01K67/0278 , A01K2217/072 , A01K2217/203 , A01K2227/105 , A01K2267/0318 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/313 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3233 , C12N2320/33
摘要： Provided herein are methods, compositions and transgenic mice useful in treating and developing treatments for VCP-associated neurodegenerative diseases.
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公开(公告)号：US11623205B2
公开(公告)日：2023-04-11
申请号：US16296590
申请日：2019-03-08
IPC分类号： B01J23/755 , B01J23/72 , C07D307/50 , B01J37/04 , C07D307/36 , C10L1/185 , B01J37/08 , B01J21/06 , B01J35/12
摘要： A method is disclosed for converting biomass into a fuel additive, the method comprising: liquefying the biomass to form a liquor; neutralizing the liquor; precipitating lignin out of the liquor; extracting furfural (FF) and 5-hydroxymethylfurfural (HMF) from the liquor; and hydrodeoxygenating (HDO) the extracted furfurals over a Cu—Ni/TiO2 catalyst. The catalyst for hydrodeoxygenating (HDO) furfural (FF) and 5-hydroxymethylfurfural (HMF) to methylated furans comprises copper-nickel (Cu—Ni) particles supported on titanium dioxide (TiO2), and wherein the copper-nickel particles form core-shell structures in which copper (Cu) is enriched at a surface of the catalyst.
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公开(公告)号：US20160325013A1
公开(公告)日：2016-11-10
申请号：US14872699
申请日：2015-10-01
发明人： Song LI , Shyam PATEL , Craig HASHI , Ngan Fong HUANG , Kyle KURPINSKI
CPC分类号： A61L27/18 , A61L27/50 , A61L2430/36 , C12M21/08 , C12M25/14 , D01D5/0076 , D10B2509/00 , C08L67/04 , C08L71/02
摘要： The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer arc aligned, and a molecule is covalcntly attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human.
摘要翻译： 本发明提供一种组合物，其包含纳米纤维聚合物，其中纳米纤维聚合物的纤维与直接或通过接头共价连接到纳米纤维聚合物上。 该分子能够共价或非共价连接至选自细胞外基质组分，生长因子及其组合的成员。 本发明还提供了使组合物和使用组合物向受试者（例如人）添加新组织的方法。
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公开(公告)号：US20140371471A1
公开(公告)日：2014-12-18
申请号：US14370733
申请日：2013-01-11
发明人： Ting Guo
IPC分类号： C07D311/12
CPC分类号： C07D311/12
摘要： A method for dynamic enhancement of chemical reactions by nanomaterials under hard X-ray irradiation. The nanomaterials were gold and platinum nanoparticles, and the chemical reaction employed was the hydroxylation of coumarin carboxylic acid. The reaction yield was enhanced 2000 times over that predicted on the basis of the absorption of X-rays only by the nanoparticles, and the enhancement was found for the first time to depend on the X-ray dose rate. The maximum turnover frequency was measured at 116×10-4 s-1 Gy-1. We call this process chemical enhancement, which is defined as the increased yield of a chemical reaction due to the chemical properties of the added materials. The chemical enhancement described here is believed to be ubiquitous and may significantly alter the outcome of chemical reactions under X-ray irradiation with the assistance of nanomaterials.
摘要翻译： 一种在硬X射线照射下由纳米材料动态增强化学反应的方法。 纳米材料是金和铂纳米颗粒，所用的化学反应是香豆素羧酸的羟基化。 基于仅通过纳米颗粒吸收X射线而预测的反应产率增加了2000倍，并且首次发现增强取决于X射线剂量率。 最大周转频率为116×10-4 s-1 Gy-1。 我们称这种过程化学增强，其定义为由于所添加的材料的化学性质引起的化学反应的增加的产率。 这里描述的化学增强被认为是普遍存在的，并且可以在纳米材料的帮助下在X射线照射下显着改变化学反应的结果。
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公开(公告)号：US20240297354A1
公开(公告)日：2024-09-05
申请号：US18595391
申请日：2024-03-04
发明人： Jennifer Lu , Michael Leveille , Han-Lin Kuo , Lexi Hefner
IPC分类号： H01M10/42 , C08F292/00 , C08G81/00 , H01M10/0565 , H01M50/383
CPC分类号： H01M10/4235 , C08F292/00 , C08G81/00 , H01M10/0565 , H01M50/383 , H01M2300/0082
摘要： Solid-state polymer electrolyte systems and methods of making the same are disclosed. The solid-state polymer electrolyte can be a multi-segmented polymer that includes two high-contrast segments. The high-contrast segments can be, respectively, soft segments and one or more hard segments. Batteries with a solid-state polymer electrolyte system is also disclosed.
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9.发明申请公开(公告)号：US20200332254A1
公开(公告)日：2020-10-22
申请号：US16799548
申请日：2020-02-24
IPC分类号： C12N5/079 , C12N5/0797 , C12N5/0735
摘要： This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations bearing markers of oligodendrocyte precursor cells. Upon further differentiation form complex processes characteristic of mature oligodendrocytes. The cells are capable of forming myelin sheaths, and can be used therapeutically improve function of the central nervous system.
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公开(公告)号：US20180140703A1
公开(公告)日：2018-05-24
申请号：US15817017
申请日：2017-11-17
发明人： Sunil J. Advani , Stephen Adams , Roger Y. Tsien
CPC分类号： A61K41/0038 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/55 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/73
摘要： Disclosed herein, the invention pertains to methods and compositions that find use in radiosensitization of tumors and tumor samples based on the ability of a tumor sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is an optional pre-targeting moiety; M is an optional macromolecular carrier; and T is a radiosensitization agent for delivery to a target, including for example a therapeutic compound, wherein T is not an auristatin, including MMAE, or a derivative thereof.
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