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公开(公告)号：US20240309102A1
公开(公告)日：2024-09-19
申请号：US18733957
申请日：2024-06-05
申请人： Lentigen Technology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C07K16/28 , A61K35/17 , A61K38/00 , C07K14/705 , C07K14/725 , C12N15/10 , C12N15/86
CPC分类号： C07K16/2866 , A61K35/17 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C12N15/1037 , C12N15/86 , A61K38/00 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N2740/15041
摘要： Chimeric antigen receptors containing CD123 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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2.发明公开公开(公告)号：US20240287054A1
公开(公告)日：2024-08-29
申请号：US18568738
申请日：2022-06-09
IPC分类号： C07D413/14 , A61K31/501 , A61K31/5377 , A61K31/55 , C07D413/04
CPC分类号： C07D413/14 , A61K31/501 , A61K31/5377 , A61K31/55 , C07D413/04
摘要： Small molecule compounds that selectively bind to non-canonical G-quadruplex (G4) structures, such as G4s in DNA found in various types of genes described herein, along with methods of using the compounds to reduce or inhibit protein (e.g., N-Myc protein) expression in cells, such as cancer cells. The compounds have a structure according to formulas described herein, or a stereoisomer, tautomer, or pharmaceutically effective salt or ester thereof.
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公开(公告)号：US12037403B2
公开(公告)日：2024-07-16
申请号：US17095982
申请日：2020-11-12
申请人： Lentigen Technology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K39/00 , A61K35/17 , A61K39/395 , C07K14/47 , C07K14/705 , C07K14/725 , C07K16/28 , C07K19/00 , C12N15/10 , C12N15/86 , A61K38/00
CPC分类号： C07K16/2866 , A61K35/17 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C12N15/1037 , C12N15/86 , A61K38/00 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N2740/15041
摘要： Chimeric antigen receptors containing CD123 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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公开(公告)号：US20240226118A1
公开(公告)日：2024-07-11
申请号：US18538065
申请日：2023-12-13
CPC分类号： A61K31/58 , A61K9/0043 , A61K9/0078 , A61P31/14
摘要： Embodiments of a method for inhibiting viral infection in a subject are provided herein. In some embodiments, the method comprises administration of a competitive antagonist of ouabain binding to ATP1A1 to inhibit respiratory syncytial virus infection in the subject.
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公开(公告)号：US11976109B2
公开(公告)日：2024-05-07
申请号：US16959644
申请日：2018-12-31
发明人： Nancy Sullivan , Kendra Leigh , John Misasi , Alberto Cagigi
IPC分类号： C07K16/10 , A61K39/00 , A61K48/00 , A61P31/14 , G01N33/569
CPC分类号： C07K16/10 , A61P31/14 , G01N33/56983 , A61K2039/505 , A61K2039/507 , A61K48/005 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/08 , G01N2400/02 , G01N2469/10
摘要： Antibodies and antigen binding fragments that specifically bind to ebolavirus glycoprotein and neutralize ebolavirus infection are disclosed. Nucleic acids encoding these antibodies, vectors, and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit an ebolavirus infection in a subject.
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公开(公告)号：US11970528B2
公开(公告)日：2024-04-30
申请号：US16780325
申请日：2020-02-03
申请人： Lentigen Technology Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C07K16/18 , A61K35/17 , A61P35/00 , A61P35/02 , C07K14/705 , C07K14/725 , C07K16/30 , C12N5/0783 , C12N15/07 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/63
CPC分类号： C07K16/18 , A61K35/17 , A61P35/00 , A61P35/02 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/30 , C12N5/0636 , C12N5/0638 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/63 , C07K2317/21 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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7.发明公开公开(公告)号：US20240117026A1
公开(公告)日：2024-04-11
申请号：US18364104
申请日：2023-08-02
申请人： The U.S.A., as Represented by the Secretary, Department of Health and Human Services , Sanaria Inc.
发明人： Robert Seder , Neville Kisalu , Azza Idris , Barbara Flynn , Stephen Hoffman
IPC分类号： C07K16/20
CPC分类号： C07K16/205 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
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公开(公告)号：US11878052B2
公开(公告)日：2024-01-23
申请号：US16773379
申请日：2020-01-27
申请人： LentigenTechnology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C12N15/113 , C12N15/31 , C07K14/47 , A61K35/17 , A61K39/00 , C07K16/28 , C07K14/705 , C07K14/725 , A61P35/00
CPC分类号： A61K39/001113 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/2803 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： Chimeric antigen receptors (CARs) containing CD22 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making CAR T cells are also disclosed.
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公开(公告)号：US20230390322A1
公开(公告)日：2023-12-07
申请号：US18032132
申请日：2021-10-12
IPC分类号： A61K31/714 , A61P3/02
CPC分类号： A61K31/714 , A61P3/02
摘要： Methods are disclosed for treating a subject with a cobalamin C (cblC) deficiency. These methods include selecting a human subject with the cblC deficiency; and administering about 5 mg to about 10 grams of methylcobalamin (MeCbl) daily to the human subject. Methods also are disclosed for treating a fetus with a cobalamin C (cblC) deficiency. The methods include selecting a female human subject pregnant with the fetus that has the cblC deficiency; and administering about 5 mg to about 10 grams of MeCbl daily to the female human subject, in order to treat the cblC deficiency in the fetus. Optionally, OHCbl can be administered to the subject.
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公开(公告)号：US20230242593A1
公开(公告)日：2023-08-03
申请号：US17946383
申请日：2022-09-16
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： KIMBERLY DOWD , BARNEY S. GRAHAM , SUNG-YOUL KO , WING-PUI KONG , JOHN MASCOLA , THEODORE PIERSON , MAYURI SHARMA , DONG YU
IPC分类号： C07K14/005 , A61K39/12 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , A61K2039/53
摘要： Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen.
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