摘要:
The present invention provides novel methods to identify polypeptide ligands for Toll-like Receptors (TLRs), such as TLR2, TLR4 and TLR5. The method involves the use of phage display technology in an iterative biopanning procedure. The invention also provides polypeptide TLR ligands identified by the methods of the invention. In preferred embodiments, the polypeptide TLR ligands so identified modulate TLR signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising a polypeptide TLR ligand identified by the methods of the invention and an antigen. The invention also provides methods of modulating TLR signaling using the polypeptide TLR ligands and vaccines of the invention.
摘要:
A remediation method and system is disclosed. A plurality of conductors is installed into the subsurface to introduce electrical current to produce heat in the subsurface. One or more agents are released into the subsurface to cause or accelerate the decomposition of one or more pre-existing halogenated organic compounds and release halogen ions, improving electrode performance.
摘要:
A habitat mount for a wall mounted taxidermy mannequin includes a habitat piece having a three dimensional first side with the appearance of one or more natural elements and an opposing generally planar second side. A tab extends outwardly from and generally parallel to a plane defined by the second side of the habitat piece. The tab is sized and shaped to mount directly to a rear side of the wall mounted taxidermy mannequin.
摘要:
A computer-performed method of modeling a physical structure. A plurality of geometric parameters specific to a type of the structure are applied to aerodynamic surface data in accordance with rules predefined for the structure type to geometrically describe a plurality of structural features. Based on the geometric describing, a plurality of points representing the structure are obtained. The points are used to model the structure.
摘要:
Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions can further include a Toll-like Receptor agonist and a carrier protein.
摘要:
A portable Dutch Oven stand comprising a low aspect ratio and few parts which are integrally pieced together into one transportable unit. In a preferred form the Dutch Oven Stand includes a tray for holding cooking fuel (typically charcoal briquettes) at a safe distance from the ground while also maintaining such fuel from falling onto the ground, and while also supporting at least one Dutch Oven during cooking. The Dutch Oven stand also comprises folding legs permanently attached to the tray, a leveling means forming a part of the tray to level the stand prior to cooking, and a rotatable platform assembly for rotating a Dutch Oven while on the stand without lifting the Dutch Oven from the stand.
摘要:
Method and system of connecting and facilitating safe and efficient electronic communications between three or more parties for the purpose of an exchange of goods and/or services between the three parties. One embodiment of the present invention uses a software script that connects buyers, sellers, and third party couriers based on how close the parties are physically located to each other. This embodiment is accomplished by having a buyer, a seller, and a courier connect to a remote location-based goods exchange server (remote server) and set up an account.
摘要:
Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick-borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response and protective immunity in a subject.
摘要:
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Control of mammalian gastro-intestinal tissues growth and repair is facilitated by the use of the proteins, making the proteins candidates for therapies.