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    Device and method for direct delivery of a therapeutic using non-newtonian fluids
    1.
    发明授权
    Device and method for direct delivery of a therapeutic using non-newtonian fluids 有权
    使用非牛顿流体直接递送治疗剂的装置和方法

    公开(公告)号：US07803141B2

    公开(公告)日：2010-09-28

    申请号：US10638426

    申请日：2003-08-12

    申请人： Samuel J. Epstein ,  Wendy Naimark ,  Toby Freyman

    发明人： Samuel J. Epstein ,  Wendy Naimark ,  Toby Freyman

    IPC分类号： A61M5/00

    CPC分类号： A61M25/00 ,  A61M25/0023 ,  A61M25/0068 ,  A61M25/0074 ,  A61M25/0082 ,  A61M2025/0057 ,  A61M2025/0073

    摘要： A device, system, and method for direct delivery of a therapeutic to a target site that utilizes the non-Newtonian characteristics of shear thinning and shear thickening to allow easy passage of a therapeutic through a delivery lumen yet facilitate retention of the therapeutic in the target site. The device, system, and method includes increasing the shear rate or shear stress of a non-Newtonian fluid having therapeutic properties thereby increasing or decreasing the viscosity of the non-Newtonian fluid.

    摘要翻译： 用于将治疗剂直接递送到靶位点的装置，系统和方法，其利用剪切稀化和剪切增厚的非牛顿特性，以允许治疗剂容易地通过输送腔，而促进治疗剂保留在靶 现场。 装置，系统和方法包括增加具有治疗性质的非牛顿流体的剪切速率或剪切应力，从而增加或降低非牛顿流体的粘度。

    Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents
    3.
    发明授权
    Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents 有权
    提供减少治疗剂流出的注射装置和递送治疗剂的方法

    公开(公告)号：US07070582B2

    公开(公告)日：2006-07-04

    申请号：US10215034

    申请日：2002-08-09

    申请人： Toby Freyman ,  Wendy Naimark ,  Tim Mickley ,  Samuel J. Epstein

    发明人： Toby Freyman ,  Wendy Naimark ,  Tim Mickley ,  Samuel J. Epstein

    IPC分类号： A61M5/32

    CPC分类号： A61M5/1582

    摘要： Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.

    摘要翻译： 提供了注射装置，其减少治疗剂从注射部位的潜在流出。 提供了具有至少包含一种或多种治疗剂的第一腔和包含用于注射到组织中的第二种材料的第二腔的装置。 提供其他装置，其具有带有注射针的内腔，以注射治疗剂和在注射针和针轨之间提供真空密封的外腔。 还提供了将治疗剂递送至组织的方法。

    Local delivery of therapeutic agent to heart valves
    4.
    发明授权
    Local delivery of therapeutic agent to heart valves 有权
    局部向心脏瓣膜递送治疗剂

    公开(公告)号：US08808364B2

    公开(公告)日：2014-08-19

    申请号：US13240792

    申请日：2011-09-22

    申请人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

    发明人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

    IPC分类号： A61F2/06 ,  A61M29/00

    CPC分类号： A61M31/002 ,  A61F2/24 ,  A61F2250/0067

    摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

    摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。

    Device and method for delivering micronized therapeutic agents in the body
    5.
    发明授权
    Device and method for delivering micronized therapeutic agents in the body 失效
    在体内递送微粉治疗剂的装置和方法

    公开(公告)号：US07892205B2

    公开(公告)日：2011-02-22

    申请号：US10455298

    申请日：2003-06-06

    申请人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

    发明人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

    IPC分类号： A61M37/00

    CPC分类号： A61M11/06 ,  A61M25/0054 ,  A61M2025/0057

    摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

    摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

    Delivery of therapeutic through multiple delivery members
    6.
    发明授权
    Delivery of therapeutic through multiple delivery members 有权
    通过多个递送成员递送治疗

    公开(公告)号：US07517338B2

    公开(公告)日：2009-04-14

    申请号：US11038241

    申请日：2005-01-21

    申请人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  William J. Shaw

    发明人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  William J. Shaw

    IPC分类号： A61M25/00 ,  A61M29/00

    CPC分类号： A61M25/0068 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M25/0071 ,  A61M25/0074 ,  A61M25/0084 ,  A61M25/10 ,  A61M2025/0058 ,  A61M2025/0076 ,  A61M2025/0079 ,  A61M2025/0085 ,  A61M2025/0681

    摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.

    摘要翻译： 本发明的实施方案涉及治疗的递送。 一种这样的装置可以包括用于递送治疗剂或其它物质的多个独立激活的注射装置。 该装置可以包括第一导管; 第一导管中的第二导管和多个递送部件注射装置。 该多个传送构件可以包括可扩张构件和多个注射元件。 第三导管可以定位在第二导管中。 该第三导管可以具有连接到可扩张构件的壁的远端和连接到第三导管的远端的多个填充管。 在一些实施方案中，每个注射元件可以在释放治疗剂之前保持加压治疗。

    Methods and apparatus for injection coating a medical device
    9.
    发明申请
    Methods and apparatus for injection coating a medical device 审中-公开
    用于注射涂覆医疗装置的方法和装置

    公开(公告)号：US20060029720A1

    公开(公告)日：2006-02-09

    申请号：US10909408

    申请日：2004-08-03

    申请人： Anastasia Panos ,  Wendy Naimark ,  Maria Palasis ,  Toby Freyman ,  Samuel Epstein

    发明人： Anastasia Panos ,  Wendy Naimark ,  Maria Palasis ,  Toby Freyman ,  Samuel Epstein

    IPC分类号： A61L33/00 ,  B05C5/00

    CPC分类号： B05C5/0208 ,  A61F2/86 ,  A61F2002/072 ,  A61L31/08 ,  A61L31/10 ,  A61L2420/02 ,  B05C13/025 ,  B05D1/002 ,  B05D1/26 ,  B05D1/30

    摘要： Methods and apparatus for coating at least a portion of the surface of medical devices using an injection coating device are disclosed. In one embodiment, the invention includes a coating method wherein an orifice of the injection coating device is placed adjacent a vertically positioned medical device, coating material is ejected from the orifice onto the medical device, and the coating material gravitationally flows downward coating the medical device. In another embodiment, an orifice of an injection coating device is positioned adjacent a horizontally positioned medical device to gravitationally flow and deposit coating material onto the medical device. These methods may be used to apply one or more coating materials, simultaneously or in sequence. In another embodiment, multiple injection coating devices may be utilized. In certain embodiments of the invention, the coating materials include therapeutic or biologically active agents.

    摘要翻译： 公开了使用注射涂覆装置涂覆医疗装置的表面的至少一部分的方法和装置。 在一个实施方案中，本发明包括一种涂覆方法，其中注射涂覆装置的孔口邻近垂直定位的医疗装置放置，涂层材料从孔口喷射到医疗装置上，并且涂覆材料重力地向下流动涂覆医疗装置 。 在另一个实施例中，注射涂覆装置的孔口邻近水平定位的医疗装置定位以重力地流动并将涂层材料沉积到医疗装置上。 这些方法可以同时或按顺序施用一种或多种涂料。 在另一个实施例中，可以使用多个注射涂覆装置。 在本发明的某些实施方案中，涂层材料包括治疗或生物活性剂。

    Decullularized extracellular matrix of conditioned body tissues and uses thereof
    10.
    发明申请
    Decullularized extracellular matrix of conditioned body tissues and uses thereof 审中-公开
    条状体组织的脱细胞细胞外基质及其用途

    公开(公告)号：US20050181016A1

    公开(公告)日：2005-08-18

    申请号：US11076328

    申请日：2005-03-10

    申请人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

    发明人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

    IPC分类号： A61K35/12 ,  A61L27/36 ,  C12N5/071 ,  A61B17/58

    CPC分类号： A61L27/3683 ,  A61K35/12 ,  A61L27/3633 ,  A61L2430/40 ,  C12N5/0679 ,  C12N2510/00

    摘要： The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix is used to form a bodily implant such as a vein, an artery, an esophagus, or a ventricular restraining device. In some embodiments of the invention, the decellularized extracellular matrix is configured to be a time released therapeutic. In another embodiment of the invention, a decellularized extracellular matrix forms an aneurysm treatment device, such as an aneurysm coil, a seal, a pouch, or a filler. In a further embodiment of the invention, decellularized extracellular matrix is used to embolize lesions, tumors, or vessels. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of body tissues are also provided.

    摘要翻译： 本发明涉及一种诸如医疗装置的装置，其具有被脱细胞的细胞外基质包被或覆盖的表面，或具有包含用于植入受试者，优选人的脱细胞的细胞外基质的组分。 在本发明的一个实施方案中，使用脱细胞的细胞外基质形成诸如静脉，动脉，食管或心室抑制装置的身体植入物。 在本发明的一些实施方案中，脱细胞的细胞外基质被配置为时间释放的治疗剂。 在本发明的另一个实施方案中，脱细胞的细胞外基质形成动脉瘤治疗装置，例如动脉瘤线圈，密封件，小袋或填充物。 在本发明的另一个实施方案中，脱细胞的细胞外基质用于栓塞病变，肿瘤或血管。 还提供了用于制备组织再生支架的方法和用于制造具有包含身体组织的脱细胞的细胞外基质的组分的涂覆或覆盖的医疗装置的方法。