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1.发明授权Method of screening apoptosis accelerating compound or anti-apoptotic compound and method of determining malignancy of neurodegenerative disease 有权筛选凋亡加速化合物或抗凋亡化合物的方法及测定神经退行性疾病恶性肿瘤的方法公开(公告)号：US07985556B2
公开(公告)日：2011-07-26
申请号：US12063381
申请日：2006-08-09
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/574 , G01N33/5011 , G01N33/6896 , G01N2333/4748 , G01N2500/02 , G01N2510/00
摘要： Screening methods for determining pro-apoptotic compounds or anti-apoptotic compounds comprise measuring the interaction between p53 and NEDL1 in the presence and in the absence of a test compound, and comparing the strength of interaction between p53 and NEDL1 in the presence and in the absence of the test compound.
摘要翻译： 用于测定促凋亡化合物或抗凋亡化合物的筛选方法包括在存在和不存在测试化合物的情况下测量p53和NEDL1之间的相互作用，并且比较p53和NEDL1在存在和不存在下的相互作用强度 的试验化合物。
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公开(公告)号：US4942452A
公开(公告)日：1990-07-17
申请号：US158673
申请日：1988-02-22
申请人： Makoto Kitano , Sueo Kawai , Asao Nishimura , Hideo Miura , Akihiro Yaguchi , Chikako Kitabayashi , Ichio Shimizu , Toshio Hatsuda , Toshinori Ozaki , Toshio Hattori , Souji Sakata
发明人： Makoto Kitano , Sueo Kawai , Asao Nishimura , Hideo Miura , Akihiro Yaguchi , Chikako Kitabayashi , Ichio Shimizu , Toshio Hatsuda , Toshinori Ozaki , Toshio Hattori , Souji Sakata
IPC分类号： H01L23/495 , H01L23/48 , H01L23/12
CPC分类号： H01L24/32 , H01L23/49503 , H01L24/83 , H01L2224/29111 , H01L2224/32057 , H01L2224/32245 , H01L2224/451 , H01L2224/45124 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2224/83385 , H01L2224/92247 , H01L24/45 , H01L24/48 , H01L24/73 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01029 , H01L2924/01033 , H01L2924/0105 , H01L2924/01082 , H01L2924/0132 , H01L2924/15738 , H01L2924/15747 , H01L2924/1576 , H01L2924/181 , H01L2924/351
摘要： A lead frame and a semiconductor device wherein a through hole is formed in the center of a semiconductor chip-mounting surface of a chip pad at the center of the lead frame, the through hole being tapered or being one which corresponds to a surface area that is greater on the surface of the chip-mounting surface of the chip pad than on the surface of the side opposite to the chip-mounting surface thereof. This prevents the occurrence of cracks in the sealing plastic portion in the step of reflow soldering of the lead frame to the substrate.
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3.发明申请METHOD OF SCREENING APOPTOSIS ACCELERATING COMPOUND OR ANTI-APOPTOTIC COMPOUND AND METHOD OF DETERMINING MALIGNANCY OF NEURODEGENERATIVE DISEASE 有权筛选加速化合物或抗微生物化合物的方法和确定神经营养因子疾病恶性的方法公开(公告)号：US20100279312A1
公开(公告)日：2010-11-04
申请号：US12063381
申请日：2006-08-09
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/68
CPC分类号： G01N33/574 , G01N33/5011 , G01N33/6896 , G01N2333/4748 , G01N2500/02 , G01N2510/00
摘要： Screening methods for determining pro-apoptotic compounds or anti-apoptotic compounds comprise measuring the interaction between p53 and NEDL1 in the presence and in the absence of a test compound, and comparing the strength of interaction between p53 and NEDL1 in the presence and in the absence of the test compound.
摘要翻译： 用于测定促凋亡化合物或抗凋亡化合物的筛选方法包括在存在和不存在测试化合物的情况下测量p53和NEDL1之间的相互作用，并且比较p53和NEDL1在存在和不存在下的相互作用强度 的试验化合物。
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4.发明授权Screening method for the identification of a drug for the development of an agent for prevention and/or treatment of Alzheimer's disease 有权用于鉴定用于开发用于预防和/或治疗阿尔茨海默氏病的药物的药物的筛选方法公开(公告)号：US07625711B2
公开(公告)日：2009-12-01
申请号：US10570346
申请日：2004-09-06
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/567
CPC分类号： G01N33/5088 , A61K38/16 , A61K45/06 , G01N2333/4709 , G01N2800/2821
摘要： The present invention provides a novel drug/agent for the prevention and/or treatment of Alzheimer's disease based on a different Alzheimer's disease onset mechanism from the amyloid hypothesis, and a method of screening for it.
摘要翻译： 本发明基于淀粉样蛋白假说的不同的阿尔茨海默病发病机制提供了用于预防和/或治疗阿尔茨海默氏病的新型药物/试剂及其筛选方法。
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5.发明授权Method of screening compound capable of accelerating or inhibiting apoptosis, apoptosis accelarator and apoptosis inhibitor 失效筛选加速抑制细胞凋亡的化合物，凋亡加速剂和凋亡抑制剂的方法公开(公告)号：US07618787B2
公开(公告)日：2009-11-17
申请号：US10594448
申请日：2005-03-23
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/53
CPC分类号： G01N33/502 , A61K38/00 , C07K14/4747 , G01N33/5008 , G01N2510/00
摘要： A method for screening a pro-apoptotic compound comprising a determination step of determining a compound enhancing interaction between p73 and IKK-α as a pro-apoptotic compound.
摘要翻译： 一种用于筛选促凋亡化合物的方法，包括测定步骤，其确定增强p73和IKK-α之间相互作用的化合物作为促凋亡化合物。
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6.发明申请Method of Screening Compound Capable of Accelerating or Inhibiting Apoptosis, Apoptosis Accelarator and Apoptosis Inhibitor 失效筛选能够加速或抑制凋亡的化合物的方法，细胞凋亡加速器和细胞凋亡抑制剂公开(公告)号：US20080032320A1
公开(公告)日：2008-02-07
申请号：US10594448
申请日：2005-03-23
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
CPC分类号： G01N33/502 , A61K38/00 , C07K14/4747 , G01N33/5008 , G01N2510/00
摘要： A method for screening a pro-apoptotic compound comprising a determination step of determining a compound enhancing interaction between p73 and IKK-α as a pro-apoptotic compound.
摘要翻译： 一种用于筛选促凋亡化合物的方法，包括测定步骤，其确定增强p73和IKK-α之间相互作用的化合物作为促凋亡化合物。
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公开(公告)号：US20070218031A1
公开(公告)日：2007-09-20
申请号：US10570346
申请日：2004-09-06
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
CPC分类号： G01N33/5088 , A61K38/16 , A61K45/06 , G01N2333/4709 , G01N2800/2821
摘要： The present invention provides a novel drug/agent for the prevention and/or treatment of Alzheimer's disease based on a different Alzheimer's disease onset mechanism from the amyloid hypothesis, and a method of screening for it.
摘要翻译： 本发明基于淀粉样蛋白假说的不同的阿尔茨海默病发病机制提供了用于预防和/或治疗阿尔茨海默氏病的新型药物/试剂及其筛选方法。
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公开(公告)号：US4203195A
公开(公告)日：1980-05-20
申请号：US862623
申请日：1977-12-20
IPC分类号： C22C1/10 , B21H8/00 , B23K20/00 , B23K20/04 , B29C63/00 , B32B3/10 , B32B37/00 , F16F15/02 , B21D39/00 , B23P11/00
CPC分类号： B21H8/00 , Y10T29/49908
摘要： One or a plurality of layers of a metallic raw material in plate form and one or a plurality of layers of wire netting are placed one over another in vertically stacked relation and then subjected to rolling to produce vibration absorbing metallic material. The metallic material produced in this way exhibits an excellent vibration damping performance.
摘要翻译： 将一层或多层板状的金属原料和一层或多层金属丝网以垂直堆叠的关系放置在另一层上，然后进行轧制以产生吸振金属材料。 以这种方式制造的金属材料表现出优异的减震性能。
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公开(公告)号：USRE37690E1
公开(公告)日：2002-05-07
申请号：US08448881
申请日：1995-05-24
申请人： Makoto Kitano , Sueo Kawai , Asao Nishimura , Hideo Miura , Akihiro Yaguchi , Chikako van Koten nee Kitabayashi , Ichio Shimizu , Toshio Hatsuda , Toshinori Ozaki , Toshio Hattori , Souji Sakata
发明人： Makoto Kitano , Sueo Kawai , Asao Nishimura , Hideo Miura , Akihiro Yaguchi , Chikako van Koten nee Kitabayashi , Ichio Shimizu , Toshio Hatsuda , Toshinori Ozaki , Toshio Hattori , Souji Sakata
IPC分类号： H01L23495
CPC分类号： H01L23/49503 , H01L24/32 , H01L24/45 , H01L24/48 , H01L24/73 , H01L2224/29007 , H01L2224/29111 , H01L2224/32014 , H01L2224/32245 , H01L2224/451 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2224/92247 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01029 , H01L2924/01033 , H01L2924/0105 , H01L2924/01082 , H01L2924/0132 , H01L2924/15738 , H01L2924/15747 , H01L2924/1576 , H01L2924/351 , H01L2924/00014 , H01L2924/00012 , H01L2924/01026 , H01L2924/01028 , H01L2924/00 , H01L2924/3512
摘要： A lead frame and a semiconductor device wherein a through hole is formed in the center of a semiconductor chip-mounting surface of a chip pad at the center of the lead frame, the through hole being tapered or being one which corresponds to a surface area that is greater on the surface of the chip-mounting surface of the chip pad than on the surface of the side opposite to the chip-mounting surface thereof. This prevents the occurrence of cracks in the sealing plastic portion in the step of reflow soldering of the lead frame to the substrate.
摘要翻译： 引线框架和半导体器件，其中在引线框架的中心处的芯片焊盘的半导体芯片安装表面的中心处形成有通孔，该通孔是锥形的，或者是对应于表面积的表面积 在芯片安装面的芯片安装面的表面上比在与芯片安装面相反的一侧的表面上更大。 这防止了在将引线框架回流焊接到基板的步骤中密封塑料部分中出现裂纹。
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公开(公告)号：US4292832A
公开(公告)日：1981-10-06
申请号：US88142
申请日：1979-10-25
IPC分类号： G10K11/162 , G10K11/16 , B21B1/38
CPC分类号： G10K11/16
摘要： A method of producing a vibration attenuating material having the steps of forming a multiplicity of grooves in the surface of a ductile raw material and subjecting the raw material to a drawing or rolling work to form a multiplicity of minute friction interfaces in the surface region of the vibration attenuating material. An improved vibration attenuating performance is ensured by a suitable selection of numerical values of factors such as relationship between the maximum depth of the friction interface and the thickness of the vibration attenuating material, pitch of the friction interfaces and so forth.
摘要翻译： 一种制造振动衰减材料的方法，具有以下步骤：在延展性原料的表面形成多个槽，并对原料进行拉伸或滚压加工，以在该表面区域形成多个微摩擦界面 振动衰减材料。 通过适当选择诸如摩擦界面的最大深度与振动衰减材料的厚度，摩擦界面的间距等因素之间的关系的数值来确保改善的振动衰减性能。
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