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    Granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof
    4.
    发明授权
    Granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof 失效
    粒细胞巨噬细胞集落刺激因子受体及其衍生物

    公开(公告)号：US5629283A

    公开(公告)日：1997-05-13

    申请号：US351149

    申请日：1994-11-23

    申请人： Nicos A. Nicola ,  Nicholas M. Gough ,  David P. Gearing ,  Donald Metcalf ,  Julie A. King

    发明人： Nicos A. Nicola ,  Nicholas M. Gough ,  David P. Gearing ,  Donald Metcalf ,  Julie A. King

    IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K14/705 ,  C12N15/12

    CPC分类号： C07K14/7153 ,  A61K38/00

    摘要： The invention provides a recombinant or synthetic receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) and biochemical and/or biological equivalents, homologues, or derivatives thereof. The GM-CSF receptor is useful inter alia in treatment and diagnosis of GM-CSF related diseases, and in screening of agonists and antagonists of binding of GM-CSF to its cell-bound receptors. The invention further provides nucleic acid sequences encoding GM-CSF receptor, recombinant DNA molecules comprising these sequences, and transformed hosts carrying the recombinant DNA molecules, as well as antibodies directed against GM-CSF receptor, and pharmaceutical compositions comprising either the GM-CSF receptor or antibodies thereto.

    摘要翻译： 本发明提供了用于粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）和生物化学和/或生物等同物，同系物或其衍生物的重组或合成受体。 GM-CSF受体特别用于治疗和诊断GM-CSF相关疾病，以及筛选GM-CSF与其细胞结合受体结合的激动剂和拮抗剂。 本发明还提供了编码GM-CSF受体的核酸序列，包含这些序列的重组DNA分子和携带重组DNA分子的转化宿主以及针对GM-CSF受体的抗体，以及包含GM-CSF受体 或其抗体。