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公开(公告)号：US20240252469A1
公开(公告)日：2024-08-01
申请号：US18578664
申请日：2022-07-08
IPC分类号： A61K31/4172 , A61P3/10
CPC分类号： A61K31/4172 , A61P3/10
摘要： The invention provides a compound of Formula (I) or a tautomer, isomer, prodrug, metal complex, or pharmaceutically acceptable salt thereof for use in the treatment of a metabolic disorder, wherein R1 is: a straight or branched C1-C20 alkoxy, preferably C1-C10 alkoxy group, optionally containing one or more rings, and/or optionally containing one or more double bonds; an alkoxycarbonyloxyalkoxy group bearing a straight, branched or cyclic alkyl; an aryloxy group; or an arylalkoxy group; R2 and R3 which can be the same or different, are: hydrogen; a straight or branched C1-C20 alkylcarbonyl or cyclic C3-C7 alkylcarbonyl group optionally containing one or more double bonds; an arylcarbonyl or arylalkylcarbonyl group; a straight or branched C1-C10 alkoxycarbonyl or cyclic C3-C7 alkoxycarbonyl group optionally containing one or more double bonds; an arylalkoxy carbonyl group; an amino group; a hydroxy group; or a group of general Formula (II) wherein Y is nitrogen, oxygen or sulfur and A is hydrogen or an amino group.
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公开(公告)号：US11971371B2
公开(公告)日：2024-04-30
申请号：US17623462
申请日：2020-06-16
发明人： Paul Evans
IPC分类号： G01N23/087 , G01N23/083 , G01N23/20 , G01N23/20008 , G01N23/205 , G01N23/2055 , G01V5/22 , G01V5/222 , G01V5/226 , G21K1/02
CPC分类号： G01N23/20083 , G01N23/083 , G01N23/087 , G01N23/20 , G01N23/20008 , G01N23/205 , G01N23/2055 , G01V5/22 , G01V5/222 , G01V5/224 , G01V5/226 , G01V5/232 , G21K1/02 , G21K1/025 , G01N2223/04 , G01N2223/045 , G01N2223/056 , G01N2223/316 , G01N2223/401
摘要： A sample inspection system contains a source of electromagnetic radiation and an apparatus that includes a beam former, a collimator and an energy resolving detector. The beam former is adapted to receive electromagnetic radiation from the source to provide a polygonal shell beam formed of at least three walls of electromagnetic radiation. The collimator has a plurality of channels adapted to receive diffracted or scattered radiation at an angle. The energy resolving detector is arranged to detect radiation diffracted or scattered by a sample upon incidence of the polygonal shell beam onto the sample and transmitted by the collimator.
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公开(公告)号：US20220381710A1
公开(公告)日：2022-12-01
申请号：US17623462
申请日：2020-06-16
发明人： Paul EVANS
IPC分类号： G01N23/20 , G01N23/083
摘要： A sample inspection system contains a source of electromagnetic radiation and an apparatus that includes a beam former, a collimator and an energy resolving detector. The beam former is adapted to receive electromagnetic radiation from the source to provide a polygonal shell beam formed of at least three walls of electromagnetic radiation. The collimator has a plurality of channels adapted to receive diffracted or scattered radiation at an angle. The energy resolving detector is arranged to detect radiation diffracted or scattered by a sample upon incidence of the polygonal shell beam onto the sample and transmitted by the collimator.
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公开(公告)号：US10775381B2
公开(公告)日：2020-09-15
申请号：US15417511
申请日：2017-01-27
IPC分类号： G01N33/574 , C12Q1/6886 , C07K16/18 , G01N33/577 , C07K16/30
摘要： There has been a recent shift in cancer therapy from one size fits all to a personalized and tailored treatment for individual patients to increase efficiency and avoid unnecessary toxicity. This invention relates to a method of determining the prognosis and suitable treatment of cancer in a subject by measuring the level of expression of SPAG5. In particular, it relates to a method where high expression of SPAG5 in tumour cells correlates with aggressive tumours.
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公开(公告)号：US10604712B2
公开(公告)日：2020-03-31
申请号：US13863105
申请日：2013-04-15
申请人： Trent University
发明人： Suresh Narine , Laziz Bouzidi , Bruce Darling , Mark Baker , Shaojun Li , Ali Mahdevari
摘要： This application relates to phase behaviors of certain triacylglycerols and fatty acid methyl esters, and how the phase behaviors of these individual components in a biodiesel fuel, as well as their combined mixtures, helps understand the fundamental mechanisms of their crystallization so as to design biodiesel fuels with improved low temperature characteristics.
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公开(公告)号：US20200057010A1
公开(公告)日：2020-02-20
申请号：US16549028
申请日：2019-08-23
发明人： Paul EVANS , Keith ROGERS
IPC分类号： G01N23/20008 , G01N23/205
摘要： A sample inspection apparatus irradiates a sample with a conical shell of X-ray or similar radiation generating a plurality of Debye rings originating from a circular path on the sample. The apparatus is provided with two detectors. A first detector receives diffracted radiation and a second detector receives radiation which is transmitted through a coded aperture provided at a detection surface of the first detector.
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公开(公告)号：US10457562B2
公开(公告)日：2019-10-29
申请号：US15558007
申请日：2016-03-15
申请人： TRENT UNIVERSITY
IPC分类号： C08L83/06 , C01B33/145 , C08G77/14 , C08G77/28 , C09D5/08 , C09D183/06
摘要： The present disclosure relates to anti-corrosion sol-gel material. In particular, the disclosure relates to a cross-linked sol-gel material comprising a first colloidal sol gel made from silanols having an epoxy functionality and a second colloidal sol gel made from silanols having a thiol functionality.
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公开(公告)号：US20170273307A1
公开(公告)日：2017-09-28
申请号：US15419712
申请日：2017-01-30
申请人： Trent University
发明人： Suresh Narine , Michael Floros
CPC分类号： A01N55/00 , A61L2/232 , A61L2202/21 , A61L2202/26 , C07F7/1804 , C07F7/1892 , C08K5/0058 , C08K5/5442 , C09D5/14 , G01N21/64 , G01N2021/6497 , G01N2021/8427
摘要： The present invention provides compounds that can be used to form antimicrobial coatings on, for example, a surface or textile, including methods of making and using such compounds. In some embodiments, the present invention provides methods of making such compounds by a single-step reaction. In some embodiments, the present invention provides methods of forming an antimicrobial coating on a surface, including applying such compounds to, for example, a surface or textile, and, optionally, treating, for example, the surface or textile, to form a coating.
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9.发明申请Methods of Making Triacylglycerol Polyols from Fractions of Metathesized Natural Oils and Uses Thereof 审中-公开从分解天然油的馏分制备三酰基甘油多元醇的方法及其用途公开(公告)号：US20160311753A1
公开(公告)日：2016-10-27
申请号：US15005522
申请日：2016-01-25
申请人： Trent University
IPC分类号： C07C67/31 , C07C67/52 , C07C67/58 , C08J9/12 , C08G18/36 , C08G18/76 , C08G18/08 , C07C67/475 , C07D301/12
CPC分类号： C07C67/31 , A61K8/85 , A61K2800/10 , A61Q19/00 , C07C67/333 , C07C67/475 , C07C67/52 , C07C67/58 , C07D301/12 , C07D301/16 , C08G18/14 , C08G18/3206 , C08G18/36 , C08G18/7657 , C08G18/7671 , C08G2101/0008 , C08G2101/0025 , C08G2101/0066 , C08G2101/0083 , C08J9/122 , C08J2205/06 , C08J2205/10 , C08J2375/06 , C08L75/04 , C07C69/533 , C07C69/58 , C07C69/675
摘要： Polyols derived from palm oil fractions of metathesized triacylglycerols, and their related physical properties are disclosed. Such metathesized triacylglycerol polyols are also used as a component of polyurethane applications, including polyurethane foams.
摘要翻译： 公开了衍生自偏碳酸三酰基甘油的棕榈油馏分的多元醇及其相关的物理性质。 这种复分解的三酰基甘油多元醇也用作聚氨酯应用的组分，包括聚氨酯泡沫。
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公开(公告)号：US09434674B2
公开(公告)日：2016-09-06
申请号：US14605344
申请日：2015-01-26
申请人： Trent University
摘要： A method of producing a diol diester, which includes reacting a fatty acid alkyl ester having 6 to 30 carbon atoms, an α,ω-alkanediol having n carbon atoms, wherein n is an integer from 2 to 22; and a basic transesterification catalyst, is provided. Use of the diol diesters as phase change materials is also provided.
摘要翻译： 一种制备二醇二酯的方法，其包括使具有6至30个碳原子的脂肪酸烷基酯，具有n个碳原子的α，ω-链烷二醇反应，其中n是2至22的整数; 和碱性酯交换催化剂。 还提供了二醇二酯作为相变材料的用途。
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