公开(公告)号：US20210285046A1

公开(公告)日：2021-09-16

申请号：US17220534

申请日：2021-04-01

Applicant: 10x Genomics, Inc. ,  Spatial Transcriptomics AB

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/6811

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US20240294974A1

公开(公告)日：2024-09-05

申请号：US18649255

申请日：2024-04-29

Applicant: 10x Genomics, Inc.

Inventor： Christina Galonska ,  Ariel Royall ,  Malte Kuhnemund

IPC: C12Q1/6841 ,  G01N1/30

CPC classification number: C12Q1/6841 ,  G01N1/30

Abstract: Provided herein are methods, compositions, and kits for the spatial analysis of target nucleic acids, or complements thereof, by their 5′ end.

公开(公告)号：US20240175080A1

公开(公告)日：2024-05-30

申请号：US18404317

申请日：2024-01-04

Applicant: 10x Genomics, Inc.

Inventor： Christina Galonska ,  Marco Mignardi

IPC: C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6855

CPC classification number: C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6855

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample.

公开(公告)号：US11332790B2

公开(公告)日：2022-05-17

申请号：US17220529

申请日：2021-04-01

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/6811 ,  C12Q1/25 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US20230080543A1

公开(公告)日：2023-03-16

申请号：US17882241

申请日：2022-08-05

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Michael Schnall-Levin ,  Christina Galonska ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876

Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

公开(公告)号：US20230064372A1

公开(公告)日：2023-03-02

申请号：US17896520

申请日：2022-08-26

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/6811 ,  C12Q1/25 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US20220127666A1

公开(公告)日：2022-04-28

申请号：US17573119

申请日：2022-01-11

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Michael Schnall-Levin ,  Christina Galonska ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6876 ,  C12Q1/6806

Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

公开(公告)号：US12275988B2

公开(公告)日：2025-04-15

申请号：US18649255

申请日：2024-04-29

Applicant: 10x Genomics, Inc.

Inventor： Christina Galonska ,  Ariel Royall ,  Malte Kuhnemund

IPC: C12Q1/6841 ,  G01N1/30

Abstract: Provided herein are methods, compositions, and kits for the spatial analysis of target nucleic acids, or complements thereof, by their 5′ end.

公开(公告)号：US11981958B1

公开(公告)日：2024-05-14

申请号：US17406824

申请日：2021-08-19

Applicant: 10x Genomics, Inc.

Inventor： Christina Galonska

IPC: C12Q1/6827 ,  C12Q1/6876

CPC classification number: C12Q1/6827 ,  C12Q1/6876 ,  C12Q2600/156

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using DNA templated ligation. For example, provided herein are methods for detecting an gDNA analyte in a biological sample where (i) the first RTL probe and second RTL probe hybridize to adjacent sequences on the gDNA analyte, (ii) enzyme-mediate cleavage of a 5′ FLAP results in release of the 5′ FLAP, and (iii) the sequence of the 5′ FLAP is determined and used to detect the gDNA analyte in the biological sample.

公开(公告)号：US20230340576A1

公开(公告)日：2023-10-26

申请号：US18302421

申请日：2023-04-18

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Michael Schnall-Levin ,  Christina Galonska ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q2600/154

Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.