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公开(公告)号：US20180217035A1
公开(公告)日：2018-08-02
申请号：US15936767
申请日：2018-03-27
发明人： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC分类号： G01N1/40 , B01J20/32 , B01D71/44 , B01D71/52 , B01D71/56 , B01J20/26 , B01J20/28 , G01N33/544 , C08J7/18 , C07K1/34 , C07K1/18 , C07F9/38 , B01D67/00
CPC分类号： G01N1/405 , B01D67/0093 , B01D71/44 , B01D71/52 , B01D71/56 , B01D2323/345 , B01D2323/38 , B01D2325/14 , B01D2325/16 , B01J20/261 , B01J20/28038 , B01J20/321 , B01J20/3242 , B01J20/3251 , B01J20/3253 , B01J20/327 , C07F9/3808 , C07K1/18 , C07K1/34 , C08J7/18 , C08J2377/00 , G01N1/4077 , G01N33/544 , G01N2001/4088 , G01N2333/924
摘要： An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US20130217032A1
公开(公告)日：2013-08-22
申请号：US13848257
申请日：2013-03-21
发明人： Jerald K. Rasmussen , Kannan Seshadri , Robert T. Fitzsimons, JR. , James I. Hembre , Catherine A. Bothof , Erin A. Satterwhite , George W. Griesgraber , Yi He , Louis C. Haddad
IPC分类号： G01N33/545
CPC分类号： C07K1/14 , B01D21/01 , C08F120/60 , C08F126/02 , C08G69/10 , C08G73/0206 , C08G73/022 , C08G73/028 , C08L77/04 , C08L79/02 , C08L83/08 , C12N7/02 , C12N11/08 , G01N33/54393 , G01N33/545 , Y10T428/249978 , Y10T428/249991 , Y10T428/2935 , Y10T428/2998 , Y10T442/20
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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公开(公告)号：US20190062369A1
公开(公告)日：2019-02-28
申请号：US16174373
申请日：2018-10-30
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, JR. , George W. Griesgraber , Yi He
IPC分类号： C07K1/22 , C09D179/02 , B01D71/56 , C07K14/765 , B01D67/00 , C07H1/08
摘要： A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
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公开(公告)号：US20160152662A1
公开(公告)日：2016-06-02
申请号：US15018129
申请日：2016-02-08
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, JR. , George W. Griesgraber , Yi He
IPC分类号： C07K1/22 , C07H1/08 , C07K14/765
CPC分类号： C07K1/22 , B01D67/0093 , B01D71/56 , B01D2323/30 , B01D2323/385 , C07H1/08 , C07K14/765 , C09D179/02 , Y10T428/31663 , Y10T428/31721 , Y10T428/31725 , Y10T428/31855 , Y10T428/31928
摘要： A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
摘要翻译： 提供了包含交联聚合物底漆层并接枝到配体官能化聚合物上的底物。 在接近或低于生物材料的pI的pH值下，接枝聚合物对结合中性或带负电荷的生物材料如细胞，细胞碎片，细菌，孢子，病毒，核酸和蛋白质具有必要的亲和力。
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公开(公告)号：US20150307526A1
公开(公告)日：2015-10-29
申请号：US14437769
申请日：2013-11-20
发明人： George W. Griesgraber , Robert T. Fitzsimons, JR. , Douglas A. Hanggi , Masayuki Nakamura , Jerald K. Rasmussen
CPC分类号： C07F7/1804 , B01D15/00 , B01D24/00 , B01J20/103 , B01J20/22 , B01J20/28004 , B01J20/28083 , B01J20/28085 , B01J20/286 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3244 , B01J20/3293 , B01J2220/80 , C07F7/1872 , C07F7/1892 , C12M25/16 , G01N1/405
摘要： Guanidine-functionalized particles and methods of making and using such particles.
摘要翻译： 胍官能化颗粒以及制造和使用这些颗粒的方法。
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公开(公告)号：US20130137158A1
公开(公告)日：2013-05-30
申请号：US13748373
申请日：2013-01-23
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Erin A. Satterwhite , Robert T. Fitzsimons, JR. , James L. Hembre , Mahfuza B. Ali
IPC分类号： C08F220/56
CPC分类号： C08F220/56 , B01D15/00 , C08F20/00 , C08F26/02 , C08F220/60 , G01N33/54393 , Y10T428/12264 , Y10T428/249991
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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公开(公告)号：US20220120649A1
公开(公告)日：2022-04-21
申请号：US17562459
申请日：2021-12-27
发明人： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC分类号： G01N1/40 , B01D71/44 , C07K1/34 , C08J7/18 , C07F9/38 , G01N33/544 , C07K1/18 , B01D67/00 , B01D71/52 , B01D71/56 , B01J20/26 , B01J20/28 , B01J20/32 , C07F5/00 , C07F5/02 , C07F5/04
摘要： An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US20200209123A1
公开(公告)日：2020-07-02
申请号：US16815749
申请日：2020-03-11
发明人： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC分类号： G01N1/40 , B01J20/32 , B01J20/28 , B01J20/26 , B01D71/56 , B01D71/52 , B01D67/00 , C07K1/18 , G01N33/544 , C07F9/38 , C08J7/18 , C07K1/34 , B01D71/44
摘要： An article that can be used for biomaterial capture comprises(a) a porous substrate; and(b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US20190285523A1
公开(公告)日：2019-09-19
申请号：US16433223
申请日：2019-06-06
发明人： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC分类号： G01N1/40 , C07K1/34 , C08J7/18 , C07F9/38 , G01N33/544 , C07K1/18 , B01D67/00 , B01D71/44 , B01J20/32 , B01J20/28 , B01J20/26 , B01D71/56 , B01D71/52
摘要： An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US20170217995A1
公开(公告)日：2017-08-03
申请号：US15488716
申请日：2017-04-17
发明人： George W. Griesgraber , Robert T. Fitzsimons, JR. , Douglas A. Hanggi , Masayuki Nakamura , Jerald K. Rasmussen
IPC分类号： C07F7/18 , B01J20/22 , B01D15/00 , B01J20/28 , B01J20/32 , G01N1/40 , B01J20/289 , B01J20/10
CPC分类号： C07F7/1804 , B01D15/00 , B01D24/00 , B01J20/103 , B01J20/22 , B01J20/28004 , B01J20/28083 , B01J20/28085 , B01J20/286 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3244 , B01J20/3293 , B01J2220/80 , C07F7/1872 , C07F7/1892 , C12M25/16 , G01N1/405
摘要： Guanidine-functionalized particles and methods of making and using such particles.
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