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公开(公告)号：US20220334108A1
公开(公告)日：2022-10-20
申请号：US17762945
申请日：2020-09-24
发明人： Frederica Sgolastra , Stephen B. Roscoe , Daniel M. Dohmeier , Masayuki Nakamura , Catherine A. Bothof , Deniz Yuksel Yurt , David D. Johnson , Kyle A. Kalstabakken , Minghua Dai , Myungchan Kang , Neil Percy , Leslie M. Horton , Stephen M. Kennedy
IPC分类号： G01N33/53 , G01N33/543 , G01N33/552 , G01N33/74 , C03C11/00 , C03C17/30
摘要： A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.
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公开(公告)号：US11446613B2
公开(公告)日：2022-09-20
申请号：US16328389
申请日：2017-08-30
发明人： Andrew W. Vail , Semra Colak Atan , Jerald K. Rasmussen , George W. Griesgraber , Catherine A. Bothof
IPC分类号： B01D71/00 , B01D69/00 , C07K1/34 , B01D71/40 , B01D69/02 , B01D69/12 , B01D71/78 , C07K16/00 , C09D133/26 , B01D67/00
摘要： An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein the first plurality of pendant groups are different than the second plurality of pendant groups; and wherein a mole ratio of the first plurality of pendant groups to the second plurality of pendant groups is in a range of 95:5 to 5:95.
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公开(公告)号：US10526366B2
公开(公告)日：2020-01-07
申请号：US15987441
申请日：2018-05-23
发明人： Jerald K. Rasmussen , Kannan Seshadri , Robert T. Fitzsimons, Jr. , James I. Hembre , Catherine A. Bothof , Erin A. Satterwhite , George W. Griesgraber , Yi He , Louis C. Haddad
IPC分类号： C07K1/14 , C08G69/10 , C08G73/02 , C08L77/04 , C08L79/02 , C08L83/08 , G01N33/543 , G01N33/545 , C12N7/02 , C12N11/08 , B01D21/01 , C08F120/60 , C08F126/02
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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公开(公告)号：US20180217035A1
公开(公告)日：2018-08-02
申请号：US15936767
申请日：2018-03-27
发明人： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC分类号： G01N1/40 , B01J20/32 , B01D71/44 , B01D71/52 , B01D71/56 , B01J20/26 , B01J20/28 , G01N33/544 , C08J7/18 , C07K1/34 , C07K1/18 , C07F9/38 , B01D67/00
CPC分类号： G01N1/405 , B01D67/0093 , B01D71/44 , B01D71/52 , B01D71/56 , B01D2323/345 , B01D2323/38 , B01D2325/14 , B01D2325/16 , B01J20/261 , B01J20/28038 , B01J20/321 , B01J20/3242 , B01J20/3251 , B01J20/3253 , B01J20/327 , C07F9/3808 , C07K1/18 , C07K1/34 , C08J7/18 , C08J2377/00 , G01N1/4077 , G01N33/544 , G01N2001/4088 , G01N2333/924
摘要： An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US09296847B2
公开(公告)日：2016-03-29
申请号：US14600117
申请日：2015-01-20
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Erin A. Satterwhite , Robert T. Fitzsimons, Jr. , James L. Hembre , Mahfuza B. Ali
IPC分类号： C08F220/56 , C08F20/00 , B01D15/00 , C08F26/02 , C08F220/60 , G01N33/543
CPC分类号： C08F220/56 , B01D15/00 , C08F20/00 , C08F26/02 , C08F220/60 , G01N33/54393 , Y10T428/12264 , Y10T428/249991
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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公开(公告)号：US20150136698A1
公开(公告)日：2015-05-21
申请号：US14400810
申请日：2013-05-23
IPC分类号： B01D71/78 , C08F255/02 , C08G69/48
CPC分类号： B01D71/78 , B01D71/40 , B01D71/56 , B01D71/76 , B01D2323/30 , B01D2323/385 , B01D2325/12 , B01J20/261 , B01J20/264 , B01J20/321 , B01J20/3282 , B01J20/3293 , B01J20/3297 , C08F255/02 , C08F283/04 , C08G69/10 , C08G69/48 , C08G73/0206 , C08G73/022 , C08G73/028 , C08J7/18 , C08J2323/06 , C08J2323/12 , C08J2377/00 , C08J2433/14 , C09D177/04 , C09D179/02 , G01N33/54393 , G01N33/545
摘要： Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.
摘要翻译： 描述了胍基配位体官能化聚合物，其制备方法和具有配体官能聚合物的接枝涂层的基材。 在接近或低于生物材料的pI处，接枝聚合物具有对结合中性或带负电荷的生物材料如细胞，细胞碎片，细菌，孢子，病毒，核酸，内毒素和蛋白质具有必要的亲和力。
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公开(公告)号：US08846203B2
公开(公告)日：2014-09-30
申请号：US14092070
申请日：2013-11-27
发明人： Catherine A. Bothof , Yi He , Jerald K. Rasmussen , Kannan Seshadri , Clinton P. Waller, Jr. , Douglas E. Weiss
IPC分类号： B32B27/00 , C08J9/42 , C12N7/00 , B01D39/16 , C07C281/16 , C07C279/12 , C07K1/34 , C08J9/28 , B01J20/285 , C08J7/18
CPC分类号： C07C279/12 , B01D39/1676 , B01J20/285 , C07C277/08 , C07C279/14 , C07C281/16 , C07K1/34 , C08F259/08 , C08F283/04 , C08G69/48 , C08J7/18 , C08J9/283 , C08J9/42 , C08J2327/16 , C08J2377/00 , C12N7/00 , Y02C10/08 , Y10T428/31855
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. The ligand functionalized substrate may be described as the grafted reaction product of a substrate and a ligand monomer of the following formula:
摘要翻译： 配体功能化底物，制备配体官能化底物的方法，以及使用官能化底物的方法。 配体官能化底物可以描述为底物和下式的配体单体的接枝反应产物：
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公开(公告)号：US20130217032A1
公开(公告)日：2013-08-22
申请号：US13848257
申请日：2013-03-21
发明人： Jerald K. Rasmussen , Kannan Seshadri , Robert T. Fitzsimons, JR. , James I. Hembre , Catherine A. Bothof , Erin A. Satterwhite , George W. Griesgraber , Yi He , Louis C. Haddad
IPC分类号： G01N33/545
CPC分类号： C07K1/14 , B01D21/01 , C08F120/60 , C08F126/02 , C08G69/10 , C08G73/0206 , C08G73/022 , C08G73/028 , C08L77/04 , C08L79/02 , C08L83/08 , C12N7/02 , C12N11/08 , G01N33/54393 , G01N33/545 , Y10T428/249978 , Y10T428/249991 , Y10T428/2935 , Y10T428/2998 , Y10T442/20
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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9.发明申请公开(公告)号：US20190194250A1
公开(公告)日：2019-06-27
申请号：US16330304
申请日：2017-08-30
发明人： Semra Colak Atan , Andrew W. Vail , Jerald K. Rasmussen , George W. Griesgraber , Catherine A. Bothof
摘要： A process for separating aggregated proteins from monomeric proteins in a biological solution, the process including: providing at least one filter element having a contacting surface, wherein the filter element comprises filter media comprising: a porous substrate; and disposed on the porous substrate, a polymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein each of a first plurality of pendant groups comprises: (1) at least one acidic group or salt thereof; and (2) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and allowing an initial biological solution to contact the contacting surface of the filter element N under conditions effective to separate the aggregated proteins from the monomeric proteins such that a final biological solution includes purified monomeric proteins.
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公开(公告)号：US10144760B2
公开(公告)日：2018-12-04
申请号：US15018129
申请日：2016-02-08
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, Jr. , George W. Griesgraber , Yi He
IPC分类号： C07K1/22 , C07K14/765 , C07H1/08 , B01D67/00 , B01D71/56 , C09D179/02
摘要： A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
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