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1.发明申请Methods and devices for removal of organic molecules from biological mixtures using anion exchange 失效使用阴离子交换从生物混合物中除去有机分子的方法和装置公开(公告)号：US20030138779A1
公开(公告)日：2003-07-24
申请号：US10027222
申请日：2001-12-20
发明人： Ranjani V. Parthasarathy , Raj Rajagopal , Erin E. Olson , Frank J. Beissel IV , William Bedingham , Barry W. Robole
IPC分类号： C12Q001/68 , C07H021/04 , C12P019/34
CPC分类号： C12N15/101 , B01F11/0002 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J41/05 , B01J47/016 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses an anion exchange material.
摘要翻译： 从使用阴离子交换材料的生物样品混合物中去除小负电荷分子的方法和装置。
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2.发明申请Biological sample processing methods and compositions that include surfactants 审中-公开包括表面活性剂的生物样品处理方法和组合物公开(公告)号：US20030017567A1
公开(公告)日：2003-01-23
申请号：US09841264
申请日：2001-04-24
发明人： Ranjani V. Parthasarathy , Raj Rajagopal , William Bedingham , Michael D. Dirksen , Christopher J. Larson , Vinod P. Menon
IPC分类号： C12N009/12
CPC分类号： C12Q1/6846 , C12Q1/6806 , C12Q1/686 , C12Q1/6862 , C12Q1/6865 , C12Q2563/107 , C12Q2523/113 , C12Q2523/313 , C12Q2527/101
摘要： Compositions containing an enzyme, a dye, and an effective amount of a surfactant selected from the group of a nonionic surfactant, a zwitterionic surfactant, and a mixture thereof and methods for processing sample materials.
摘要翻译： 含有酶，染料和有效量的选自非离子表面活性剂，两性离子表面活性剂及其混合物的表面活性剂的组合物和用于处理样品材料的方法。
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3.发明申请公开(公告)号：US20040092001A1
公开(公告)日：2004-05-13
申请号：US10698302
申请日：2003-10-31
IPC分类号： C12M001/34
CPC分类号： C12M33/04 , C12M23/04 , C12M23/22 , C12M25/02 , G01N2001/282 , G01N2001/288
摘要： Thin film culture devices are described that have positioning structures, as well as methods for harvesting cells from colonies on the culture device based on location of colonies on the device relative to the positioning structures. In addition, a computer readable medium encoded with a computer program is described that identifies position of colonies relative to the positioning structures.
摘要翻译： 描述了具有定位结构的薄膜培养装置，以及基于相对于定位结构在装置上的集落位置从培养装置上的菌落收集细胞的方法。 此外，描述了用计算机程序编码的计算机可读介质，其识别殖民地相对于定位结构的位置。
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公开(公告)号：US20030127152A1
公开(公告)日：2003-07-10
申请号：US10347667
申请日：2003-01-21
IPC分类号： B65B001/14
CPC分类号： G01N27/44704
摘要： Sample processing devices with electrophoresis channels and methods of loading the electrophoresis channels with electrophoresis sieving polymer while rotating the sample processing device are disclosed. In some instances, the electrophoresis channels may be arranged radially relative to the axis of rotation of the sample processing device. In other sample processing devices, the electrophoresis channels may be arranged in curved arcs that are concentric about the center of the sample processing device (which preferably corresponds to the axis of rotation).
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公开(公告)号：US20030124506A1
公开(公告)日：2003-07-03
申请号：US10034993
申请日：2001-12-28
IPC分类号： C12Q001/00 , C12P001/00 , G01N033/566 , G01N021/00 , G01N031/00 , G01N033/00 , C12M001/34 , C12M003/00
CPC分类号： B01L3/50851 , B01L7/52 , B01L7/54 , B01L9/523 , B01L2300/0803 , B01L2300/1861 , G01N35/025 , G01N2035/00326 , Y10T436/111666
摘要： Sample processing systems and methods of using those systems for processing sample materials located in devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include connection apparatus that allow for rapid and easy removal and/or replacement of base plates.
摘要翻译： 公开了使用这些系统来处理位于与系统分离的设备中的样品材料的样品处理系统和方法。 样品处理系统包括在系统操作期间样品处理装置位于其上的旋转底板。 这些系统还包括允许快速且容易地移除和/或更换底板的连接装置。
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公开(公告)号：US20020001848A1
公开(公告)日：2002-01-03
申请号：US09837073
申请日：2001-04-18
发明人： William Bedingham , Barry W. Robole
IPC分类号： G01N001/18
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/021 , B01L2200/147 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2300/1822 , B01L2300/1861 , B01L2300/1872 , B01L2400/0409 , B01L2400/0677 , B01L2400/0688 , F27B9/16 , F27D5/00 , Y10T436/111666 , Y10T436/115831 , Y10T436/25375 , Y10T436/2575
摘要： Devices, methods, and systems for processing sample materials are disclosed. The present invention may provide a bridge between standard microtiter plate systems, methods, protocols, etc. (that include wells arranged in rectangular arrays) and rotating sample processing devices and systems that allow users to obtain the rapid processing advantages of the more advanced sample processing devices. The sample processing devices preferably include a rectangular body to improve compatibility of the sample processing devices of the present invention with equipment designed for use with more conventional microtiter plates (which are typically rectangular in shape). The sample processing devices also include at least one set of process chambers arranged in one or more circular arcs and may include input and/or output chambers arranged in a rectilinear grid array.
摘要翻译： 公开了用于处理样品的装置，方法和系统。 本发明可以提供标准微量滴定板系统，方法，方案等（包括以矩形阵列布置的孔）之间的桥梁，以及旋转的样品处理装置和系统，其允许用户获得更先进的样品处理的快速加工优点 设备。 样品处理装置优选地包括矩形体，以提高本发明的样品处理装置与设计用于与更常规的微量滴定板（其形状通常为矩形）一起使用的设备的相容性。 样品处理装置还包括布置在一个或多个圆弧中的至少一组处理室，并且可以包括以直线网格阵列布置的输入和/或输出室。
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公开(公告)号：US20040137634A1
公开(公告)日：2004-07-15
申请号：US10339447
申请日：2003-01-09
发明人： Barry W. Robole , William Bedingham
IPC分类号： B01L003/00
CPC分类号： B01L3/502715 , B01L3/5025 , B01L3/502723 , B01L2200/0684 , B01L2300/044 , B01L2300/0803 , B01L2300/0864 , B01L2300/0887 , B01L2400/0409 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： Sample processing devices including process chambers having bypass slots and methods of using the same are disclosed. The bypass slots are formed in the sidewalls of the process chambers and are in fluid communication with distribution channels used to deliver fluid sample materials to the process chambers.
摘要翻译： 公开了包括具有旁路槽的处理室的采样处理装置及其使用方法。 旁路槽形成在处理室的侧壁中并且与用于将流体样品材料输送到处理室的分配通道流体连通。
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8.发明申请公开(公告)号：US20020110906A1
公开(公告)日：2002-08-15
申请号：US09797343
申请日：2001-03-01
IPC分类号： C12M001/34
摘要： Thin film culture devices are described that have positioning structures, as well as methods for harvesting cells from colonies on the culture device based on location of colonies on the device relative to the positioning structures. In addition, a computer readable medium encoded with a computer program is described that identifies position of colonies relative to the positioning structures.
摘要翻译： 描述了具有定位结构的薄膜培养装置，以及基于相对于定位结构在装置上的集落位置从培养装置上的菌落收集细胞的方法。 此外，描述了用计算机程序编码的计算机可读介质，其识别殖民地相对于定位结构的位置。
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公开(公告)号：US20040179974A1
公开(公告)日：2004-09-16
申请号：US10808124
申请日：2004-03-24
发明人： William Bedingham , Barry W. Robole
IPC分类号： G01N001/00
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/021 , B01L2200/147 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2300/1822 , B01L2300/1861 , B01L2300/1872 , B01L2400/0409 , B01L2400/0677 , B01L2400/0688 , F27B9/16 , F27D5/00 , Y10T436/111666 , Y10T436/115831 , Y10T436/25375 , Y10T436/2575
摘要： Devices, methods, and systems for processing sample materials are disclosed. The present invention may provide a bridge between standard microtiter plate systems, methods, protocols, etc. (that include wells arranged in rectangular arrays) and rotating sample processing devices and systems that allow users to obtain the rapid processing advantages of the more advanced sample processing devices. The sample processing devices preferably include a rectangular body to improve compatibility of the sample processing devices of the present invention with equipment designed for use with more conventional microtiter plates (which are typically rectangular in shape). The sample processing devices also include at least one set of process chambers arranged in one or more circular arcs and may include input and/or output chambers arranged in a rectilinear grid array.
摘要翻译： 公开了用于处理样品的装置，方法和系统。 本发明可以提供标准微量滴定板系统，方法，方案等（包括以矩形阵列布置的孔）之间的桥梁，以及旋转的样品处理装置和系统，其允许用户获得更先进的样品处理的快速加工优点 设备。 样品处理装置优选地包括矩形体，以提高本发明的样品处理装置与设计用于与更常规的微量滴定板（其形状通常为矩形）一起使用的设备的相容性。 样品处理装置还包括布置在一个或多个圆弧中的至少一组处理室，并且可以包括以直线网格阵列布置的输入和/或输出室。
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10.发明申请Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix 失效在疏水基质中使用亲水性固体载体从生物混合物中除去有机分子的方法和装置公开(公告)号：US20030120062A1
公开(公告)日：2003-06-26
申请号：US10027226
申请日：2001-12-20
发明人： Ranjani V. Parthasarathy , Raj Rajagopal , Vicky L. Morris , William Bedingham , Barry W. Robole
IPC分类号： C07H021/04
CPC分类号： C12N15/1006 , Y10T428/25 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses a solid-phase extraction material that includes a hydrophilic solid support at least partially embedded within a hydrophobic matrix.
摘要翻译： 用于从生物样品混合物中除去小负电荷分子的方法和装置，所述生物样品混合物使用固相萃取材料，其包括至少部分嵌入疏水基质内的亲水性固体支持物。
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