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公开(公告)号：US20240279799A1
公开(公告)日：2024-08-22
申请号：US18649302
申请日：2024-04-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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公开(公告)号：US20190390329A1
公开(公告)日：2019-12-26
申请号：US16455354
申请日：2019-06-27
Applicant: Agilent Technologies, Inc.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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公开(公告)号：US10895009B2
公开(公告)日：2021-01-19
申请号：US16455354
申请日：2019-06-27
Applicant: Agilent Technologies, Inc.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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公开(公告)号：US20150198611A1
公开(公告)日：2015-07-16
申请号：US14664709
申请日：2015-03-20
Applicant: Agilent Technologies, Inc.
Inventor： Magdalena Anna Ostrowski , Rudolf Grimm , Kevin P. Killeen , Karla M. Robotti
CPC classification number: G01N33/6842 , B01D15/08 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L2200/10 , B01L2300/0627 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0421 , B01L2400/0487 , B01L2400/0644 , F16K99/0001 , G01N1/405 , G01N27/44791 , G01N30/465 , G01N30/6095 , G01N30/7266 , G01N2030/085 , G01N2400/00 , H01J49/00
Abstract: Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans. The devices and methods significantly improve the speed and sensitivity of glycan analysis.
Abstract translation: 提供了用于分析糖蛋白聚糖谱的微流体装置和方法。 装置的一些实施方案包括用于切割聚糖的去糖基化柱，用于去除蛋白质的可选清洁柱，用于富集聚糖的捕集塔，以及用于分解聚糖的分离柱。 装置和方法显着提高了聚糖分析的速度和灵敏度。
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公开(公告)号：US20240287673A1
公开(公告)日：2024-08-29
申请号：US18649133
申请日：2024-04-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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Patent Agency Ranking
公开(公告)号：US10209259B2
公开(公告)日：2019-02-19
申请号：US14664709
申请日：2015-03-20
Applicant: Agilent Technologies, Inc.
Inventor： Magdalena Anna Ostrowski , Rudolf Grimm , Kevin P. Killeen , Karla M. Robotti
IPC: B01L3/00 , G01N33/00 , G01N33/68 , F16K99/00 , G01N27/447 , G01N30/46 , G01N30/60 , G01N30/72 , B01D15/08 , G01N1/40 , G01N30/08 , H01J49/00
Abstract: Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans. The devices and methods significantly improve the speed and sensitivity of glycan analysis.
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公开(公告)号：US20160363568A1
公开(公告)日：2016-12-15
申请号：US15241786
申请日：2016-08-19
Applicant: Agilent Technologies, Inc.
Inventor： Kevin P. Killeen , Hubert Kuderer , Karsten Kraiczek
CPC classification number: G01N30/74 , G01J2003/102 , G01N21/05 , G01N21/31 , G01N2021/0346 , G01N2021/3129 , G01N2021/3133 , G01N2021/3148 , G01N2021/317 , G01N2030/027 , G01N2201/06153 , G01N2201/0627 , G01N2201/0638
Abstract: A fluid separation system for separating compounds of a sample fluid in a mobile phase comprises a detector adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal on the optical stimulus signal. The detector comprises a light source adapted to provide an output light beam as the optical stimulus signal. The light source comprises a plurality of light emitting elements each adapted to emit a light beam having a respective wavelength, and a diffracting element. The plurality of light emitting elements are arranged that emitted light beams impinging on the diffracting element in a respective angle dependent on the respective wavelength are diffracted by the diffracting element into the output light beam.
Abstract translation: 用于分离流动相中样品流体的化合物的流体分离系统包括适于通过向样品流体提供光刺激信号并且在光刺激信号上接收响应信号来检测分离的化合物的检测器。 检测器包括适于提供输出光束作为光刺激信号的光源。 光源包括多个适于发射具有各自波长的光束的发光元件和衍射元件。 多个发光元件被布置成使得衍射元件以相应的角度照射在衍射元件上的发射光束被衍射元件衍射成输出光束。
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公开(公告)号：US20240279798A1
公开(公告)日：2024-08-22
申请号：US18649268
申请日：2024-04-29
Applicant: Agilent Technologies, Inc.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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公开(公告)号：US20240279796A1
公开(公告)日：2024-08-22
申请号：US18649199
申请日：2024-04-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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公开(公告)号：US20240279793A1
公开(公告)日：2024-08-22
申请号：US18649004
申请日：2024-04-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
CPC classification number: C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
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