公开(公告)号：US10941427B2

公开(公告)日：2021-03-09

申请号：US15675068

申请日：2017-08-11

Applicant: AJINOMOTO CO., INC. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Mitsuhiro Kishino ,  Hiroyuki Kojima ,  Hideo Hosono ,  Michikazu Hara ,  Masaaki Kitano ,  Toshiharu Yokoyama ,  Toru Numaguchi ,  Munenobu Ito ,  Kazuteru Yamada ,  Hiromi Noguchi

IPC: C12P13/04 ,  C12P13/08 ,  C12P13/14 ,  C12P1/00 ,  C12P7/02 ,  C12P7/40 ,  C12P19/04 ,  C12P21/00 ,  B01J21/00 ,  B01J23/02 ,  B01J23/46 ,  B01J27/24 ,  B01J35/00 ,  B01J37/04 ,  B01J37/08 ,  C07C273/00 ,  C01C1/04 ,  C01C1/18 ,  C01C1/28 ,  C01B21/38 ,  C12M1/00 ,  C12N1/00 ,  C07C273/02 ,  B01J21/06

Abstract: A production system for a product selected from a nitrogen-containing product and a fermented and cultured product that does not involve (or can minimize) the transport of liquid ammonia can include: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported metal catalyst containing as a support one or more selected from the group consisting of: i) a conductive mayenite compound; ii) a two-dimensional electride compound or a precursor thereof; and iii) a complex formed of a support base containing at least one metal oxide selected from ZrO2, TiO2, CeO2, and MgO and a metal amide represented by a formula M(NH2)x (where M represents one or more selected from Li, Na, K, Be, Mg, Ca, Sr, Ba, and Eu; and x represents a valence number of M) supported by the support base.

公开(公告)号：US09045789B2

公开(公告)日：2015-06-02

申请号：US13914872

申请日：2013-06-11

Applicant: AJINOMOTO CO., INC.

Inventor： Yousuke Nishio ,  Youko Yamamoto ,  Kazuteru Yamada ,  Kosuke Yokota

IPC: C12P13/14 ,  C12P7/50 ,  C12N15/52 ,  C12N9/04 ,  C12N9/02 ,  C12N9/16 ,  C12N9/88 ,  C12P7/58 ,  C12P13/00 ,  C12P13/04 ,  C12P13/10 ,  C12P13/24

CPC classification number: C12P13/14 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/16 ,  C12N9/88 ,  C12N15/52 ,  C12P7/50 ,  C12P7/58 ,  C12P13/001 ,  C12P13/04 ,  C12P13/10 ,  C12P13/24 ,  C12Y101/01113 ,  C12Y102/01026 ,  C12Y103/05001 ,  C12Y301/01068 ,  C12Y402/01082

Abstract: A target substance can be produced by culturing a bacterium having an ability to produce 2-ketoglutaric acid or a derivative thereof, and an ability to produce xylonic acid from xylose, which is imparted with xylonate dehydratase activity, 2-keto-3-deoxyxylonate dehydratase activity and 2-ketoglutaric semialdehyde dehydrogenase activity, or in which these activities are enhanced, in a medium containing xylose as a carbon source to produce and accumulate the target substance in the medium, and collecting the target substance from the medium.

Abstract translation: 目标物质可以通过培养具有生产2-酮戊二酸或其衍生物的能力的细菌和从赋予木糖酸脱水酶活性的木糖中产生木糖酸的能力，2-酮-3-脱氧木糖酸脱水酶 活性和2-酮戊二醛半醛脱氢酶活性，或其中这些活性增强的培养基，在含有木糖作为碳源的培养基中培养和累积目标物质，并从培养基中收集目标物质。

公开(公告)号：US11198894B2

公开(公告)日：2021-12-14

申请号：US16268082

申请日：2019-02-05

Applicant: AJINOMOTO CO., INC.

Inventor： Kazuteru Yamada ,  Ye Zhang ,  Kenji Abe ,  Naoki Iwanaga ,  Ryo Takeshita ,  Yuri Uehara ,  Chika Hikichi ,  Yasuhiro Oota

IPC: C12P13/20 ,  C12P13/08 ,  C12P13/04 ,  C12N15/09 ,  A23K50/80 ,  A23K10/18 ,  A01K61/10 ,  A01K61/59 ,  C12N1/20 ,  C12P13/14

Abstract: A method for producing an L-amino acid such as L-lysine is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a carotenoid biosynthesis enzyme is increased, in a medium, and collecting the L-amino acid from the medium.

公开(公告)号：US20160222394A1

公开(公告)日：2016-08-04

申请号：US15134674

申请日：2016-04-21

Applicant: AJINOMOTO CO., INC.

Inventor： Kazuteru Yamada ,  Yoshihiko Hara

IPC: C12N15/77 ,  C12P13/04 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12P19/40 ,  C12N9/92

CPC classification number: C12N15/77 ,  C07K14/34 ,  C12N1/20 ,  C12N9/0008 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/92 ,  C12P13/04 ,  C12P19/32 ,  C12P19/34 ,  C12P19/40 ,  C12P21/02 ,  C12Y102/01026 ,  C12Y207/01017 ,  C12Y402/01082 ,  C12Y503/01005

Abstract: A method for producing a target substance is provided. A target substance is produced by culturing a coryneform bacterium, which is able to produce a target substance, and which also has an improved ability to assimilate xylose as a result of the introduction of a mutation into a coding region and/or an expression control region of the NCgl2954 gene on the chromosome of the bacterium. The culture is conducted in a medium containing xylose, and the target substance can be collected from the medium.

Abstract translation: 提供了制造目标物质的方法。 通过培养能够产生目标物质的棒状细菌产生目标物质，并且由于将突变引入编码区和/或表达控制区而具有改善的木糖同化能力 的NCgl2954基因在细菌的染色体上。 培养物在含有木糖的培养基中进行，并且可以从培养基中收集目标物质。

公开(公告)号：US12241103B2

公开(公告)日：2025-03-04

申请号：US17019666

申请日：2020-09-14

Applicant: AJINOMOTO CO., INC. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Mitsuhiro Kishino ,  Hiroyuki Kojima ,  Hideo Hosono ,  Michikazu Hara ,  Masaaki Kitano ,  Toshiharu Yokoyama ,  Toru Numaguchi ,  Munenobu Ito ,  Kazuteru Yamada ,  Hiromi Noguchi

IPC: C12P13/14 ,  B01J23/02 ,  B01J23/04 ,  B01J23/46 ,  B01J23/58 ,  B01J35/00 ,  B01J37/02 ,  C01C1/04 ,  C12M1/00 ,  C12N1/20 ,  C12P13/08

Abstract: Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

公开(公告)号：US10155952B2

公开(公告)日：2018-12-18

申请号：US15134674

申请日：2016-04-21

Applicant: AJINOMOTO CO., INC.

Inventor： Kazuteru Yamada ,  Yoshihiko Hara

IPC: C12N15/77 ,  C12P19/32 ,  C12P21/02 ,  C07K14/34 ,  C12N1/20 ,  C12P19/34 ,  C12P19/40 ,  C12N9/00 ,  C12N9/12 ,  C12N9/88 ,  C12N9/92 ,  C12P13/04 ,  C12N9/02

Abstract: A method for producing a target substance is provided. A target substance is produced by culturing a coryneform bacterium, which is able to produce a target substance, and which also has an improved ability to assimilate xylose as a result of the introduction of a mutation into a coding region and/or an expression control region of the NCgl2954 gene on the chromosome of the bacterium. The culture is conducted in a medium containing xylose, and the target substance can be collected from the medium.

公开(公告)号：US20170342449A1

公开(公告)日：2017-11-30

申请号：US15675068

申请日：2017-08-11

Applicant: AJINOMOTO CO., INC. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Mitsuhiro Kishino ,  Hiroyuki Kojima ,  Hideo Hosono ,  Michikazu Hara ,  Masaaki Kitano ,  Toshiharu Yokoyama ,  Toru Numaguchi ,  Munenobu Ito ,  Kazuteru Yamada ,  Hiromi Noguchi

IPC: C12P13/08 ,  C12M1/00 ,  C01C1/04 ,  B01J37/08 ,  B01J37/04 ,  B01J35/00 ,  B01J27/24 ,  B01J23/46 ,  B01J23/02 ,  C12P13/14 ,  B01J21/06

CPC classification number: C12P13/08 ,  B01J21/066 ,  B01J23/02 ,  B01J23/462 ,  B01J27/24 ,  B01J35/0006 ,  B01J37/04 ,  B01J37/088 ,  C01B21/38 ,  C01C1/0411 ,  C01C1/0417 ,  C01C1/0488 ,  C01C1/185 ,  C01C1/28 ,  C07C273/02 ,  C12M1/00 ,  C12M29/26 ,  C12N1/00 ,  C12P1/00 ,  C12P7/02 ,  C12P7/40 ,  C12P13/04 ,  C12P13/14 ,  C12P19/04 ,  C12P21/00 ,  Y02P20/52

Abstract: Provided is a novel production system for a product selected from a nitrogen-containing product and a fermented and cultured product that does not involve (or can minimize) the transport of liquid ammonia. A production system for a product selected from a nitrogen-containing product and a fermented and cultured product can include: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported metal catalyst containing as a support one or more selected from the group consisting of: i) a conductive mayenite compound; ii) a two-dimensional electride compound or a precursor thereof; and iii) a complex formed of a support base containing at least one metal oxide selected from ZrO2, TiO2, CeO2, and MgO and a metal amide represented by a formula M(NH2)x (where M represents one or more selected from Li, Na, K, Be, Mg, Ca, Sr, Ba, and Eu; and x represents a valence number of M) supported by the support base; and a production apparatus that produces a product selected from a nitrogen-containing product and a fermented and cultured product using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

公开(公告)号：US10808267B2

公开(公告)日：2020-10-20

申请号：US15675113

申请日：2017-08-11

Applicant: AJINOMOTO CO., INC. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Mitsuhiro Kishino ,  Hiroyuki Kojima ,  Hideo Hosono ,  Michikazu Hara ,  Masaaki Kitano ,  Toshiharu Yokoyama ,  Toru Numaguchi ,  Munenobu Ito ,  Kazuteru Yamada ,  Hiromi Noguchi

IPC: C12M1/00 ,  C12P13/08 ,  C12P13/14 ,  B01J23/58 ,  C12N1/20 ,  C01C1/04 ,  B01J23/02 ,  B01J23/04 ,  B01J23/46 ,  B01J35/00 ,  B01J37/02

Abstract: Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

公开(公告)号：US20190161780A1

公开(公告)日：2019-05-30

申请号：US16268082

申请日：2019-02-05

Applicant: AJINOMOTO CO., INC.

Inventor： Kazuteru Yamada ,  Ye Zhang ,  Kenji Abe ,  Naoki Iwanaga ,  Ryo Takeshita ,  Yuri Uehara ,  Chika Hikichi ,  Yasuhiro Oota

IPC: C12P13/08 ,  C12P13/04 ,  C12P13/20 ,  C12P13/14 ,  C12N1/20 ,  A23K50/80 ,  A23K10/18 ,  A01K61/10 ,  A01K61/59

Abstract: A method for producing an L-amino acid such as L-lysine is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a carotenoid biosynthesis enzyme is increased, in a medium, and collecting the L-amino acid from the medium.

公开(公告)号：US20170342450A1

公开(公告)日：2017-11-30

申请号：US15675113

申请日：2017-08-11

Applicant: AJINOMOTO CO., INC. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Mitsuhiro Kishino ,  Hiroyuki Kojima ,  Hideo Hosono ,  Michikazu Hara ,  Masaaki Kitano ,  Toshiharu Yokoyama ,  Toru Numaguchi ,  Munenobu Ito ,  Kazuteru Yamada ,  Hiromi Noguchi

IPC: C12P13/14 ,  C12M1/00 ,  C01C1/04 ,  B01J37/02 ,  B01J35/00 ,  B01J23/58 ,  B01J23/46 ,  B01J23/04 ,  C12P13/08 ,  B01J23/02

Abstract: Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.