公开(公告)号：US20250082820A1

公开(公告)日：2025-03-13

申请号：US18607924

申请日：2024-03-18

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Darin J. Messina ,  Elizabeta Pavlovic ,  Cunqi Cui ,  Kate M. Smither

IPC: A61L27/20 ,  A61F2/52 ,  A61L27/18 ,  C08B37/08 ,  C08H1/00

Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.

公开(公告)号：US20240342072A1

公开(公告)日：2024-10-17

申请号：US18582331

申请日：2024-02-20

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Nicholas J. Manesis

IPC: A61K8/73 ,  A61K8/04 ,  A61L27/20 ,  A61L27/52 ,  A61Q19/00 ,  A61Q19/08 ,  C08B37/08

CPC classification number: A61K8/735 ,  A61K8/042 ,  A61L27/20 ,  A61L27/52 ,  A61Q19/00 ,  A61Q19/08 ,  C08B37/0072 ,  A61K2800/91 ,  A61L2400/06 ,  A61L2430/34

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

公开(公告)号：US20200054786A1

公开(公告)日：2020-02-20

申请号：US16341382

申请日：2016-10-13

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Dennis E. VanEpps ,  Iossif A. Strehin

IPC: A61L27/26 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61K8/04 ,  A61K8/73 ,  A61Q19/08 ,  A61Q19/00 ,  C08B37/08

Abstract: The present disclosure provides dermal fillers comprising hyaluronic acid-based hydrogels. The hydrogels are coacervates formed through ionic interactions between anionic polysaccharides, such as hyaluronic acid, and cationic polysaccharides, such as chitosan. The dermal fillers are useful for augmenting soft tissues, reducing soft tissue defects and improving skin quality.

公开(公告)号：US20200030490A1

公开(公告)日：2020-01-30

申请号：US16595481

申请日：2019-10-08

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61L27/52 ,  A61K8/73 ,  A61Q19/08 ,  A61K8/04 ,  A61L27/26 ,  A61L27/36

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US20180303742A1

公开(公告)日：2018-10-25

申请号：US16024559

申请日：2018-06-29

Applicant: Allergan, Inc.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61Q19/08 ,  A61L27/20 ,  C08H1/00 ,  C08B37/08 ,  A61K8/73 ,  C08J3/24 ,  C08L89/00 ,  C08J3/075 ,  A61L27/22 ,  C08L5/08 ,  A61L27/52 ,  A61L27/36

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

公开(公告)号：US09737633B2

公开(公告)日：2017-08-22

申请号：US14829201

申请日：2015-08-18

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Nicholas J. Manesis ,  Athene Wan Chie Chan

IPC: A61K8/73 ,  A61K8/67 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61Q19/08 ,  A61L27/20 ,  A61K47/48 ,  C08B37/08 ,  A61K8/04 ,  A61L27/52

CPC classification number: A61L27/20 ,  A61K8/042 ,  A61K8/676 ,  A61K8/735 ,  A61K47/60 ,  A61K47/61 ,  A61K2800/91 ,  A61L27/00 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/08 ,  C08B37/0072

Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

公开(公告)号：US20170151367A1

公开(公告)日：2017-06-01

申请号：US15428985

申请日：2017-02-09

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Jacob F. Pollock ,  Nicholas Manesis

IPC: A61L27/20 ,  A61L27/54 ,  A61L27/52 ,  A61L27/50

CPC classification number: A61L27/20 ,  A61K8/41 ,  A61K8/42 ,  A61K8/735 ,  A61K9/0024 ,  A61K31/137 ,  A61K31/167 ,  A61K31/728 ,  A61K31/738 ,  A61K45/06 ,  A61K47/36 ,  A61K2800/31 ,  A61K2800/91 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/402 ,  A61L2300/43 ,  A61L2300/436 ,  A61L2300/45 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  A61K2300/00 ,  C08L5/08

Abstract: Dermal fillers are provided, particularly hyaluronic acid-based dermal fillers containing additives, for example, unstable additives, the dermal fillers being provided in an anhydrous state for extended shelf life.

公开(公告)号：US09662422B2

公开(公告)日：2017-05-30

申请号：US14535033

申请日：2014-11-06

Applicant: Allergan, Inc.

Inventor： Jacob F. Pollock ,  Lauren E. Kokai ,  Cunqi Cui ,  Xiaojie Yu ,  Dennis E. Van Epps ,  Darin J. Messina

IPC: A61L27/52 ,  A61K8/65 ,  A61Q19/08 ,  A61L27/24 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61K8/73 ,  A61K8/04 ,  A61L27/20 ,  A61L27/54 ,  A61L27/58

CPC classification number: A61L27/52 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L89/06 ,  C08L5/08

Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

公开(公告)号：US20160361247A1

公开(公告)日：2016-12-15

申请号：US15244587

申请日：2016-08-23

Applicant: Allergan, Inc.

Inventor： Elizabeta Pavlovic ,  Monica A. Serban ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61K8/64 ,  A61Q19/08

CPC classification number: A61K8/64 ,  A61K8/735 ,  A61L27/20 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/04 ,  A61L2430/34 ,  A61Q19/08 ,  C08B37/0072 ,  C08H1/00 ,  C08J3/075 ,  C08J3/246 ,  C08J2305/08 ,  C08J2489/00 ,  C08J2489/04 ,  C08L5/08 ,  C08L89/00

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

Abstract translation: 可用作真皮填料的组合物和使用这种组合物治疗各种皮肤和软组织病症的方法。 真皮填料可以包括使用例如两个交联剂连接到透明质酸的丝，并可用于治疗面部缺陷，面部缺陷，面部增大，乳房缺陷，隆胸或乳房重建。

公开(公告)号：US20150297492A1

公开(公告)日：2015-10-22

申请号：US14693628

申请日：2015-04-22

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Jacob F. Pollock ,  Nicholas Manesis

IPC: A61K8/73 ,  A61K8/41 ,  A61Q19/00 ,  A61K8/42

CPC classification number: A61L27/20 ,  A61K8/41 ,  A61K8/42 ,  A61K8/735 ,  A61K9/0024 ,  A61K31/137 ,  A61K31/167 ,  A61K31/728 ,  A61K31/738 ,  A61K45/06 ,  A61K47/36 ,  A61K2800/31 ,  A61K2800/91 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/402 ,  A61L2300/43 ,  A61L2300/436 ,  A61L2300/45 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  A61K2300/00 ,  C08L5/08

Abstract: Dermal fillers are provided, particularly hyaluronic acid-based dermal fillers containing additives, for example, unstable additives, the dermal fillers being provided in an anhydrous state for extended shelf life.

Abstract translation: 提供皮肤填充剂，特别是含有添加剂的透明质酸类皮肤填充剂，例如不稳定添加剂，以无水状态提供皮肤填充剂以延长保质期。