专利检索 ap:("AQUINOX PHARMACEUTICALS (CANADA) INC.") AND inv:"Curtis HARWIG" 第 1 页

1.

发明申请
INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION 有权

公开(公告)号：US20210032264A1

公开(公告)日：2021-02-04

申请号：US17045675

申请日：2019-04-05

申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.

发明人： Curtis HARWIG , Jeremy D. PETTIGREW , Jennifer CROSS , Jeyaprakashnarayanan SEENISAMY , Mahesh Narayan KEREGADDE , Karthikeyan IYANAR

IPC分类号： C07D493/10 , C07D231/54 , C07D401/08 , C07D403/08 , C07D417/08 , A61P29/00

摘要： Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

2.

发明申请
SHIP1 MODULATORS AND METHODS RELATED THERETO 有权
标题翻译： SHIP1调制器及其相关方法

公开(公告)号：US20160257671A2

公开(公告)日：2016-09-08

申请号：US14759622

申请日：2014-01-07

申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.

发明人： Lloyd F. MACKENZIE , Thomas B. MACRURY , Curtis HARWIG , David BOGUCKI , Jeffery R. RAYMOND , Jeremy D. PETTIGREW , Vladimir KHLEBNIKOV , Rudong SHAN

IPC分类号： C07D405/12 , C07C49/835 , C07C225/20 , C07C43/215 , C07C43/23 , C07C39/17 , C07C62/34 , C07C62/32 , C07C233/60 , C07C233/32 , C07C255/47 , C07C323/20 , C07C233/76 , C07D241/24 , C07D213/81 , C07D233/64 , C07D249/08 , C07D295/112 , C07D213/75 , C07C275/26 , C07C275/64 , C07D295/215 , C07D211/66 , C07C317/22 , C07C279/16 , C07C311/07 , C07C311/18 , C07D401/12 , C07C49/84

CPC分类号： A61K31/4965 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496 , C07B2200/07 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/23 , C07C49/83 , C07C49/835 , C07C49/84 , C07C62/32 , C07C62/34 , C07C217/84 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C233/76 , C07C235/82 , C07C237/08 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C311/18 , C07C317/22 , C07C323/20 , C07C2602/28 , C07D211/66 , C07D213/38 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/112 , C07D295/215 , C07D401/12 , C07D405/12

摘要： Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

摘要翻译： 其中n，R1，R4a，R4b，R5，R7和R8在本文中定义的式（I）化合物或其药学上可接受的盐在本文中描述。所公开的化合物具有作为SHIP1调节剂的活性，因此可用于治疗将受益于SHIP1调节的各种疾病，障碍或病症中的任何一种。还公开了包含式（I）化合物与药学上可接受的载体或稀释剂的组合物，以及通过将这些化合物施用于有此需要的动物的SHIP1调节方法。

3.

发明申请
SHIP1 MODULATORS AND METHODS RELATED THERETO 有权
标题翻译： SHIP1调制器及其相关方法

公开(公告)号：US20150336935A1

公开(公告)日：2015-11-26

申请号：US14759622

申请日：2014-01-07

申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.

发明人： Lloyd F. MACKENZIE , Thomas B. MACRURY , Curtis HARWIG , David BOGUCKI , Jeffery R. RAYMOND , Jeremy D. PETTIGREW , Vladimir KHLEBNIKOV , Rudong SHAN

IPC分类号： C07D405/12 , C07C49/835 , C07C225/20 , C07C43/215 , C07C43/23 , C07C39/17 , C07C62/34 , C07C62/32 , C07C233/60 , C07C233/32 , C07C255/47 , C07C323/20 , C07C233/76 , C07D241/24 , C07D213/81 , C07D233/64 , C07D249/08 , C07D295/112 , C07D213/75 , C07C275/26 , C07C275/64 , C07D295/215 , C07D211/66 , C07C317/22 , C07C279/16 , C07C311/07 , C07C311/18 , C07D401/12 , C07C49/84

CPC分类号： A61K31/4965 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496 , C07B2200/07 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/23 , C07C49/83 , C07C49/835 , C07C49/84 , C07C62/32 , C07C62/34 , C07C217/84 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C233/76 , C07C235/82 , C07C237/08 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C311/18 , C07C317/22 , C07C323/20 , C07C2602/28 , C07D211/66 , C07D213/38 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/112 , C07D295/215 , C07D401/12 , C07D405/12

摘要： Compounds of formula (I): where, n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

摘要翻译： 本文描述式（I）的化合物：其中，n，R1，R4a，R4b，R5，R7和R8如本文所定义，或其药学上可接受的盐。所公开的化合物具有作为SHIP1调节剂的活性，因此可用于治疗将受益于SHIP1调节的各种疾病，障碍或病症中的任何一种。还公开了包含式（I）化合物与药学上可接受的载体或稀释剂的组合物，以及通过将这些化合物施用于有此需要的动物的SHIP1调节方法。

4.

发明申请
INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION 有权

公开(公告)号：US20210155615A1

公开(公告)日：2021-05-27

申请号：US17045626

申请日：2019-04-05

申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.

发明人： Curtis HARWIG , Jeremy D. PETTIGREW , Jennifer CROSS , Jeyaprakashnarayanan SEENISAMY , Mahesh Narayan KEREGADDE , Samir Satish KHER

IPC分类号： C07D413/06 , C07D231/54 , C07D405/12 , C07D401/08 , C07D403/08 , C07D403/04 , C07D241/42 , C07D239/84 , C07D239/74 , C07D209/08 , C07D263/56 , C07D261/20 , A61P29/00

摘要： Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

5.

发明申请
HEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION 有权

公开(公告)号：US20210024571A1

公开(公告)日：2021-01-28

申请号：US17045688

申请日：2019-04-05

申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.

发明人： Curtis HARWIG , Jeremy D. PETTIGREW , Jennifer CROSS , Jeyaprakashnarayanan SEENISAMY , Mahesh Narayan KEREGADDE , Samir Satish KHER , Karthikeyan IYANAR

IPC分类号： C07J71/00 , A61P23/00

摘要： wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.