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公开(公告)号:US5292558A
公开(公告)日:1994-03-08
申请号:US742391
申请日:1991-08-08
申请人: Adam Heller , Panagiotis Argitis , Joseph C. Carls
发明人: Adam Heller , Panagiotis Argitis , Joseph C. Carls
IPC分类号: C23C18/08 , H01L21/768 , B05D5/12 , C23C16/06 , H01L21/314
CPC分类号: C23C18/08 , H01L21/76838 , H01L21/76877
摘要: A method for forming interconnections in microelectronic devices, including interconnections through small vias between different layers in the microelectronic devices include the spin coating of a film comprising a polyoxometalate and an organic material on the substrate. The film is optionally patterned by lithography, the polymer is removed, and the polyoxometalate is reduced to a metal layer. The metal layer may in one embodiment provide a nucleating zone for the deposition of metal.
摘要翻译: 在微电子器件中形成互连的方法,包括通过微电子器件中的不同层之间的小通孔的相互连接,包括在衬底上包含多金属氧酸盐和有机材料的膜的旋涂。 通过光刻任选图案化该膜,除去聚合物,并将多金属氧酸盐还原成金属层。 在一个实施例中,金属层可以提供用于沉积金属的成核区域。
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公开(公告)号:US5178989A
公开(公告)日:1993-01-12
申请号:US384705
申请日:1989-07-21
IPC分类号: G03F7/095 , G03F7/004 , G03F7/038 , G03F7/09 , G03F7/26 , G03F7/32 , G03F7/36 , H01L21/027 , H01L21/30
CPC分类号: G03F7/36 , G03F7/0042 , G03F7/0045 , G03F7/038 , G03F7/094 , G03F7/32
摘要: Pattern forming and transferring processes using radiation sensitive materials based upon mixtures of polyoxometalates and organic compounds. The processes involve establishing a layer of such radiation sensitve material on one or more layers of underlying materials. A pattern is formed in the layer of radiation sensitive material by exposing selected areas of the layer to radiation. The pattern may then be transferred into the underlying layers of material. Methods for developing patterns in layers of radiation sensitive materials, so as to hinder leaching of etch resistant substances included in the radiation sensitive materials, are also provided.
摘要翻译: 使用基于多金属氧酸盐和有机化合物的混合物的辐射敏感材料的图案形成和转印方法。 这些过程涉及在一层或多层下层材料上建立一层这样的辐射敏感材料。 通过将层的选定区域暴露于辐射,在辐射敏感材料层中形成图案。 然后可以将图案转移到下面的材料层中。 还提供了用于在辐射敏感材料层中开发图案的方法,以便阻止包含在辐射敏感材料中的耐蚀刻物质的浸出。
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公开(公告)号:US09066697B2
公开(公告)日:2015-06-30
申请号:US13283562
申请日:2011-10-27
申请人: Thomas Peyser , Adam Heller
发明人: Thomas Peyser , Adam Heller
IPC分类号: A61B5/1486 , A61B5/1473 , A61B5/00 , A61B5/145
CPC分类号: A61B5/14532 , A61B5/0002 , A61B5/0031 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/4839 , A61B5/742 , A61B5/7445 , G06F19/00
摘要: An analyte monitor including a sensor, a sensor control unit, and a display unit is disclosed. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
摘要翻译: 公开了一种包括传感器,传感器控制单元和显示单元的分析物监视器。 分析物监测器还可以是药物递送系统的一部分,以基于使用传感器获得的数据来改变分析物的水平。
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公开(公告)号:US08880137B2
公开(公告)日:2014-11-04
申请号:US10420057
申请日:2003-04-18
申请人: James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人: James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号: A61B5/05 , A61B5/00 , A61B5/1473 , A61B5/1468 , A61B5/145 , G06F19/00 , A61B5/1486 , H01L23/495 , H01L23/31
CPC分类号: A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号:US08741590B2
公开(公告)日:2014-06-03
申请号:US11695612
申请日:2007-04-03
申请人: Adam Heller , Michael V. Pishko
发明人: Adam Heller , Michael V. Pishko
IPC分类号: C12Q1/54
CPC分类号: C12Q1/54 , C12Q1/006 , Y10S435/817 , Y10S435/917 , Y10S435/962
摘要: A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
摘要翻译: 描述了设计用于皮下体内电导率监测葡萄糖的小直径柔性电极。 电极被设计成允许“一点”体内校准,即即使在血清或血液的其它电反应物质的存在下也能在零葡萄糖浓度下具有零输出电流。 电极优选为三层或四层,其中层叠在聚酰胺绝缘金线的尖端上的凹槽内。 第一葡萄糖浓度 - 电流转导层用电绝缘和葡萄糖通量限制层(第二层)涂覆,其上任选地沉积固定的干扰消除辣根过氧化物酶基膜(第三层)。 外(第四)层是生物相容的。
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公开(公告)号:US08650751B2
公开(公告)日:2014-02-18
申请号:US12569350
申请日:2009-09-29
申请人: Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人: Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号: H01R43/20
CPC分类号: G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译: 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室,并且在至少一些情况下,传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度,使用诸如库仑法,电流分析法; 和电位法。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。
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公开(公告)号:US08641619B2
公开(公告)日:2014-02-04
申请号:US12643977
申请日:2009-12-21
申请人: James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人: James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
CPC分类号: A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号:US08480580B2
公开(公告)日:2013-07-09
申请号:US11737671
申请日:2007-04-19
申请人: Howard Wolpert , Adam Heller
发明人: Howard Wolpert , Adam Heller
IPC分类号: A61B5/00
CPC分类号: A61B5/1486 , A61B5/0002 , A61B5/1118 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/4839 , A61B5/7275 , A61B5/7445 , A61B2560/0252 , A61B2560/063 , A61M5/14244 , A61M5/1723 , A61M2205/3569 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , H01L2924/00
摘要: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号:US08473021B2
公开(公告)日:2013-06-25
申请号:US12533680
申请日:2009-07-31
申请人: James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人: James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
CPC分类号: A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号:US08444834B2
公开(公告)日:2013-05-21
申请号:US12051835
申请日:2008-03-19
申请人: Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人: Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号: G01N27/327 , C07F15/00
CPC分类号: C07F15/0026 , C12Q1/002 , C12Q1/004
摘要: Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand.
摘要翻译: 描述了用作电化学生物传感器中的氧化还原介体的聚合物。 连接到聚合物主链上的过渡金属络合物可用作酶基电化学传感器中的氧化还原介体。 在这种情况下,过渡金属配合物以高速率接受电子或将电子转移到酶,并且还与传感器快速交换电子。 过渡金属络合物包括至少一个取代或未取代的双咪唑配体,并且还可以包括第二取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。
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