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1.发明申请公开(公告)号：US20100008862A1
公开(公告)日：2010-01-14
申请号：US12460007
申请日：2009-07-10
申请人： Aihua Fu , Shan X. Wang , Sanjiv Sam Gambhir
发明人： Aihua Fu , Shan X. Wang , Sanjiv Sam Gambhir
CPC分类号： A61K49/1848 , A61K9/5094 , A61K49/0002 , A61K49/0032 , A61K49/0045 , A61K49/005 , A61K49/0093 , A61K49/1833 , A61K49/1866 , A61K51/1244 , B82Y5/00 , B82Y15/00 , G01N33/5434 , G01N33/582 , G01N33/587
摘要： Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like.
摘要翻译： 本公开的实施例提供了纳米探针，成像方法，成像靶的方法，制备纳米探针的方法等。
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公开(公告)号：US08722017B2
公开(公告)日：2014-05-13
申请号：US12460007
申请日：2009-07-10
申请人： Aihua Fu , Shan X. Wang , Sanjiv Sam Gambhir
发明人： Aihua Fu , Shan X. Wang , Sanjiv Sam Gambhir
IPC分类号： A61B5/055
CPC分类号： A61K49/1848 , A61K9/5094 , A61K49/0002 , A61K49/0032 , A61K49/0045 , A61K49/005 , A61K49/0093 , A61K49/1833 , A61K49/1866 , A61K51/1244 , B82Y5/00 , B82Y15/00 , G01N33/5434 , G01N33/582 , G01N33/587
摘要： Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like.
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3.发明申请公开(公告)号：US20120052009A1
公开(公告)日：2012-03-01
申请号：US13199428
申请日：2011-08-30
申请人： Zheng Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
发明人： Zheng Cheng , Sanjiv Sam Gambhir , Zheng Miao , Hongguang Liu , Gang Ren
IPC分类号： A61K51/08 , G01N33/566 , C07K14/00
CPC分类号： A61K49/0004 , A61K38/16 , A61K49/0008 , A61K49/14 , A61K51/08 , A61K51/088 , G01N33/574 , G01N33/74 , G01N2333/71
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of detecting the over-expression of epidermal growth factor receptor (EGFR) in a subject or sample, methods of diagnosing the presence of one or more angiogenesis related diseases or related biological events in a subject or sample, method of monitoring the progress of one or more angiogenesis related diseases or related biological events in a subject or sample, a 18F-FBEM-CYS-ZEGFR:1907 probe, compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe, and pharmaceutical compositions including a 18F-FBEM-CYS-ZEGFR:1907 probe and the like.
摘要翻译： 根据本公开的目的，如本文所体现和广泛描述的，本公开的实施方案在一方面涉及检测受试者中表皮生长因子受体（EGFR）的过度表达的方法 或样品，诊断受试者或样品中一种或多种血管生成相关疾病或相关生物事件的存在的方法，监测受试者或样品中一种或多种血管生成相关疾病或相关生物学事件进展的方法，18F- FBEM-CYS-ZEGFR：1907探针，包含18F-FBEM-CYS-ZEGFR：1907探针的组合物和包含18F-FBEM-CYS-ZEGFR：1907探针等的药物组合物。
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公开(公告)号：US20110059439A1
公开(公告)日：2011-03-10
申请号：US12555901
申请日：2009-09-09
申请人： Srabani Bhaumik , Sanjiv Sam Gambhir , Ramasamy Paulmurugan , Shahriar Yaghoubi , Byeong-Cheol Ahn , Natesh Parashurama
发明人： Srabani Bhaumik , Sanjiv Sam Gambhir , Ramasamy Paulmurugan , Shahriar Yaghoubi , Byeong-Cheol Ahn , Natesh Parashurama
CPC分类号： C12Q1/6897 , C12N15/1086 , C12N15/85 , C12N2830/008 , C12N2830/20 , C12N2840/20 , C12Q2565/102 , C12Q2545/101
摘要： An expression vector, comprising a first reporter nucleic acid sequence operably linked to a first expression control sequence comprising a promoter; and a second reporter nucleic acid sequence operably linked to a second expression control sequence that comprises a response element that is activated or inactivated as one or more of the cells differentiate or dedifferentiate. Methods and kits for imaging and monitoring stem cells comprising the expression vector are also provided.
摘要翻译： 表达载体，其包含与包含启动子的第一表达控制序列可操作地连接的第一报道核酸序列; 和与第二表达控制序列可操作地连接的第二报道核酸序列，其包含作为一种或多种分化或去分化的细胞被活化或失活的响应元件。 还提供了用于成像和监测包含表达载体的干细胞的方法和试剂盒。
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公开(公告)号：US10712277B2
公开(公告)日：2020-07-14
申请号：US12932912
申请日：2011-03-09
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes), methods of using Raman agents and Raman imaging devices to image or detect a signal, and the like.
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公开(公告)号：US20140046179A1
公开(公告)日：2014-02-13
申请号：US14113142
申请日：2012-04-30
IPC分类号： A61B6/03
CPC分类号： A61B6/037 , A61B6/508 , A61B6/5235
摘要： Simultaneous dual-isotope positron emission tomography (PET) is used to improve disease evaluation. Two distinct molecular probes are simultaneously provided to the imaging target. One of the probes is labeled with a radionuclide that emits positrons to provide double coincidence events in PET. The other probe is labeled with a radionuclide that emits positrons+prompt gammas to provide triple coincidence events in PET. One of the probes is a metabolic probe, and the other probe is a selective probe that includes a ligand or antibody that is biologically responsive to receptor/antigen status. A PET system is employed that can provide simultaneous double coincidence and triple coincidence PET images. The resulting images provide simultaneous metabolic imaging and receptor/antigen imaging. Applications include disease evaluation, such as cancer staging (e.g., for breast cancer, prostate cancer, etc.).
摘要翻译： 同时使用双同位素正电子发射断层扫描（PET）来改善疾病评估。 两个不同的分子探针同时提供给成像靶。 其中一个探针用发射正电子的放射性核素标记，以在PET中提供双重重合事件。 另一个探针用放射性核素标记，其发射正电子+提示的伽马，以在PET中提供三重重合事件。 探针之一是代谢探针，另一个探针是选择性探针，其包括对受体/抗原状态具有生物学反应的配体或抗体。 采用PET系统可同时提供双重重合和三重重合PET图像。 所得图像提供同时代谢成像和受体/抗原成像。 应用包括疾病评价，例如癌症分期（例如，用于乳腺癌，前列腺癌等）。
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公开(公告)号：US20140316255A1
公开(公告)日：2014-10-23
申请号：US14241790
申请日：2012-08-23
申请人： Ellis Garai , Cristina Zavaleta , Michael Mandella , Jonathan Liu , Sanjiv Sam Gambhir , Christopher H. Contag
发明人： Ellis Garai , Cristina Zavaleta , Michael Mandella , Jonathan Liu , Sanjiv Sam Gambhir , Christopher H. Contag
CPC分类号： A61B5/0075 , A61B1/07 , A61B5/0079 , A61B5/0084 , A61B10/02 , A61B34/20 , A61B2034/2057 , A61K49/0095 , B82Y15/00 , G01J1/0433 , G01J3/0213 , G01J3/0218 , G01J3/18 , G01J3/2803 , G01J3/44 , G01N21/658
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes) or systems, methods of using Raman agents, Raman imaging devices, and/or systems to image or detect a signal, and the like.
摘要翻译： 根据本公开的目的，如本文所体现和广泛描述的，本公开的实施例在一个方面涉及拉曼成像装置（例如，拉曼内窥镜探针）或系统，使用拉曼剂的方法 ，拉曼成像装置和/或用于对信号进行成像或检测的系统等。
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8.发明授权Split protein self complementing fragments, systems, and methods of use thereof 失效分裂蛋白质自身互补片段，系统及其使用方法公开(公告)号：US07601517B2
公开(公告)日：2009-10-13
申请号：US11651956
申请日：2007-01-10
CPC分类号： G01N33/5035 , C07K2319/61 , C12N9/0069 , C12Y113/12007 , G01N2500/10
摘要： Briefly described, embodiments of this disclosure include split protein systems, fusion proteins, methods of producing the split protein systems, methods of screening macromolecular delivery vehicles, methods of cellular localization of proteins, methods of monitoring cell fusion, methods of detecting phosphorylation, and the like.
摘要翻译： 简要描述，本公开的实施方案包括裂解蛋白质系统，融合蛋白质，产生裂解蛋白质系统的方法，筛选大分子递送载体的方法，蛋白质的细胞定位方法，监测细胞融合的方法，检测磷酸化的方法，以及 喜欢。
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公开(公告)号：US09320478B2
公开(公告)日：2016-04-26
申请号：US14113142
申请日：2012-04-30
CPC分类号： A61B6/037 , A61B6/508 , A61B6/5235
摘要： Simultaneous dual-isotope positron emission tomography (PET) is used to improve disease evaluation. Two distinct molecular probes are simultaneously provided to the imaging target. One of the probes is labeled with a radionuclide that emits positrons to provide double coincidence events in PET. The other probe is labeled with a radionuclide that emits positrons+prompt gammas to provide triple coincidence events in PET. One of the probes is a metabolic probe, and the other probe is a selective probe that includes a ligand or antibody that is biologically responsive to receptor/antigen status. A PET system is employed that can provide simultaneous double coincidence and triple coincidence PET images. The resulting images provide simultaneous metabolic imaging and receptor/antigen imaging. Applications include disease evaluation, such as cancer staging (e.g., for breast cancer, prostate cancer, etc.).
摘要翻译： 同时使用双同位素正电子发射断层扫描（PET）来改善疾病评估。 两个不同的分子探针同时提供给成像靶。 其中一个探针用发射正电子的放射性核素标记，以在PET中提供双重重合事件。 另一个探针用放射性核素标记，其发射正电子+提示的伽马，以在PET中提供三重重合事件。 探针之一是代谢探针，另一个探针是选择性探针，其包括对受体/抗原状态具有生物学反应的配体或抗体。 采用PET系统可同时提供双重重合和三重重合PET图像。 所得图像提供同时代谢成像和受体/抗原成像。 应用包括疾病评价，例如癌症分期（例如，用于乳腺癌，前列腺癌等）。
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10.发明授权Triple-fusion constructs and methods of monitoring human embryonic stem cells 有权三重融合构建体和监测人类胚胎干细胞的方法公开(公告)号：US08945862B2
公开(公告)日：2015-02-03
申请号：US13358838
申请日：2012-01-26
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0603 , C12N5/0657 , C12N5/069 , C12N2506/02 , C12N2510/00
摘要： Embodiments of the present disclosure include triple-fusion human embryonic stem cells, methods of imaging triple-fusion human embryonic stem cells, triple-fusion polynucleotides, triple-fusion proteins, methods of monitoring the progression of human embryonic stem cells, methods of making isolated triple-fusion human embryonic stem cells, and the like.
摘要翻译： 本公开的实施方案包括三重融合人胚胎干细胞，成像三重融合人胚胎干细胞的方法，三重融合多核苷酸，三重融合蛋白，监测人胚胎干细胞进展的方法，分离的方法 三重融合人类胚胎干细胞等。
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