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公开(公告)号：US08557253B2
公开(公告)日：2013-10-15
申请号：US12899492
申请日：2010-10-06
申请人： Alain Francon , Michel Chevalier , Nadege Moreno , Eric Calvosa , Sandrine Cigarini , Virginie Fabre
发明人： Alain Francon , Michel Chevalier , Nadege Moreno , Eric Calvosa , Sandrine Cigarini , Virginie Fabre
IPC分类号： A61K39/205 , A61K47/00 , C12N7/02
CPC分类号： A61K47/26 , A61K39/12 , A61K39/205 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K2039/5252 , C12N2760/20134
摘要： The invention relates to a vaccine composition comprising: a) inactivated whole virus, and b) a stabilizing excipient which comprises: i. a buffer solution, ii. a mixture of essential and nonessential amino acids, iii. a disaccharide, iv. a polyol, v. a chelating agent, vi. urea or a urea derivative, and vii. a nonionic surfactant.
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公开(公告)号：US20110081380A1
公开(公告)日：2011-04-07
申请号：US12899492
申请日：2010-10-06
申请人： Alain Françon , Michel Chevalier , Nadège Moreno , Eric Calvosa , Sandrine Cigarini , Virginie Fabre
发明人： Alain Françon , Michel Chevalier , Nadège Moreno , Eric Calvosa , Sandrine Cigarini , Virginie Fabre
IPC分类号： A61K39/205 , A61K39/12 , A61K47/26 , A61P31/14
CPC分类号： A61K47/26 , A61K39/12 , A61K39/205 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K2039/5252 , C12N2760/20134
摘要： The invention relates to a vaccine composition comprising: a) inactivated whole virus, and b) a stabilizing excipient which comprises: i. a buffer solution, ii. a mixture of essential and nonessential amino acids, iii. a disaccharide, iv. a polyol, v. a chelating agent, vi. urea or a urea derivative, and vii. a nonionic surfactant.
摘要翻译： 本发明涉及疫苗组合物，其包含：a）灭活的全病毒，和b）稳定赋形剂，其包括：i。 缓冲溶液，ii。 必需和非必需氨基酸的混合物，iii。 二糖，iv。 多元醇，v。螯合剂，vi。 脲或脲衍生物，和vii。 非离子表面活性剂。
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公开(公告)号：US06664049B1
公开(公告)日：2003-12-16
申请号：US09600664
申请日：2001-03-21
申请人： Michel Chevalier
发明人： Michel Chevalier
IPC分类号： C12Q168
摘要： Method and device for cell lysis in which a liquid mixture of bateria or eukaryoptic cells and of a lysing agent is produced continuously, and this mixture is caused to flow immediately in a steady stream inside a tubing (7), the flow rate of this stream being adjusted as a function of the diameter and of the length of the tubing (7) so as to obtain a substantially homegenous cell lysate at the outlet (8) of the said tubing.
摘要翻译： 用于细胞裂解的方法和装置，其中连续地产生液体或真核细胞和裂解剂的液体混合物，并使该混合物在管（7）内的稳定流中立即流动，该流的流速 作为管道（7）的直径和长度的函数进行调整，以便在所述管道的出口（8）处获得基本上自生的细胞裂解物。
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公开(公告)号：US4623263A
公开(公告)日：1986-11-18
申请号：US667347
申请日：1984-11-01
申请人： Paul Barberi , Pierre Bergez , Maurice Brun , Michel Chevalier , Charles Eyraud , Jean-Francois Quinson
发明人： Paul Barberi , Pierre Bergez , Maurice Brun , Michel Chevalier , Charles Eyraud , Jean-Francois Quinson
CPC分类号： G01N15/088 , G01N25/4866
摘要： An apparatus for the thermal measurement of the texture of a porous body, including a measuring head, a measuring assembly and a processing and control circuit. The measuring head is provided with two identical cylindrical cells, a measuring cell and a reference cell, arranged in a furnace. The measuring assembly measures the mean temperature of the measuring cell, and measures a calorific effect in the measuring cell, and includes a calorific effect detector, a calibration circuit, a temperature regulator including a furnace heater. The measuring circuit supplies a temperature signal and a calorific effect signal to the processing and control circuit, which in turn controls the heater.
摘要翻译： 一种用于热测量多孔体的织构的装置，包括测量头，测量组件和处理和控制电路。 测量头设置有两个相同的圆柱形单元，测量单元和参考单元，布置在炉中。 测量组件测量测量单元的平均温度，并测量测量单元中的发热效应，并包括发热效应检测器，校准电路，包括炉加热器的温度调节器。 测量电路向处理和控制电路提供温度信号和发热效应信号，进而控制加热器。
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公开(公告)号：US4103218A
公开(公告)日：1978-07-25
申请号：US729800
申请日：1976-10-05
CPC分类号： H01Q3/385
摘要： A set of phase shifters associated with an array of radiators of an electronically scanning antenna are each controlled by a current-limiting amplifier which has an input stage in series with an electronic switch and an output stage connected to a source of operating voltage normally blocking a pair of diodes in the associated phase shifter. A feedback loop between the two amplifier stages includes another diode serving to stabilize the current flow through the phase-shifter diodes upon closure of the electronic switch by a control device and triggering of the input stage by a signal from a reference-voltage generator.
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公开(公告)号：US09005623B2
公开(公告)日：2015-04-14
申请号：US12246803
申请日：2008-10-07
IPC分类号： A61K39/42 , A61K39/145 , A61K39/21 , G01N33/53 , C07K16/10 , A61K31/737 , G01N33/569
CPC分类号： C07K16/1018 , A61K31/737 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The invention relates to a flu virus hemagglutinin-specific monoclonal antibody which recognizes an antigenic structure present both on the H1 and H3 subtypes of the hemagglutinins of type A flu viruses and on the hemagglutinin of type B flu viruses. Within type B flu viruses, the antigenic structure is present on the hemagglutinins of type B flu viruses belonging to the B/Victoria group and/or to the B/Yagamata group.
摘要翻译： 本发明涉及一种流感病毒血凝素特异性单克隆抗体，其识别存在于A型流感病毒的血凝素的H1和H3亚型以及B型流感病毒的血凝素上的抗原结构。 在B型流感病毒中，抗原结构存在于属于B /维多利亚组和/或B / Yagamata组的B型流感病毒的血细胞凝集素上。
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公开(公告)号：US20090092620A1
公开(公告)日：2009-04-09
申请号：US12246803
申请日：2008-10-07
CPC分类号： C07K16/1018 , A61K31/737 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The invention relates to a flu virus hemagglutinin-specific monoclonal antibody which recognizes an antigenic structure present both on the H1 and H3 subtypes of the hemagglutinins of type A flu viruses and on the hemagglutinin of type B flu viruses. Within type B flu viruses, the antigenic structure is present on the hemagglutinins of type B flu viruses belonging to the B/Victoria group and/or to the B/Yagamata group.
摘要翻译： 本发明涉及一种流感病毒血凝素特异性单克隆抗体，其识别存在于A型流感病毒的血凝素的H1和H3亚型以及B型流感病毒的血凝素上的抗原结构。 在B型流感病毒中，抗原结构存在于属于B /维多利亚组和/或B / Yagamata组的B型流感病毒的血细胞凝集素上。
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公开(公告)号：US06861253B2
公开(公告)日：2005-03-01
申请号：US10040349
申请日：2002-01-07
申请人： Robert Brasseur , Benoit Charloteaux , Michel Chevalier , Raphaelle El Habib , Tino Krell , Regis Sodoyer
发明人： Robert Brasseur , Benoit Charloteaux , Michel Chevalier , Raphaelle El Habib , Tino Krell , Regis Sodoyer
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , Y10S530/826
摘要： The present invention thus provides a polypeptide capable of forming a structure corresponding to or mimicking the intermediate of gp41 as well as its use in a vaccine for treating or preventing HIV infections.
摘要翻译： 因此，本发明提供了能够形成对应于或模拟gp41中间体的结构的多肽，以及其在疫苗中用于治疗或预防HIV感染的用途。
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公开(公告)号：US07056519B2
公开(公告)日：2006-06-06
申请号：US10438691
申请日：2003-05-15
IPC分类号： A61K39/385
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C07K16/1063 , C12N2740/16122
摘要： The present invention relates to a method for inducing antibodies neutralizing HIV primary isolates in a mammal, comprising administration of a pharmaceutical composition comprising a polypeptide represented by the formula N-L-C, in which: N represents the amino acid sequence 25–81 of gp41, C represents the amino acid sequence 112–157 of gp41, and L represents a flexible linking sequence comprising from 2 to 30 amino acids.
摘要翻译： 本发明涉及一种用于诱导在哺乳动物中中和HIV初级分离物的抗体的方法，包括给予包含由式NLC表示的多肽的药物组合物，其中：N代表gp41的氨基酸序列25-81，C代表 gp41的氨基酸序列112-157，L代表包含2-30个氨基酸的柔性连接序列。
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公开(公告)号：US5001491A
公开(公告)日：1991-03-19
申请号：US769892
申请日：1977-02-15
申请人： Michel Chevalier , Roger Bischoff , Yves Loiseau
发明人： Michel Chevalier , Roger Bischoff , Yves Loiseau
摘要： A diode phase-shifting device for an electronically scanning antenna includes a cut-off device designed to operate when the phase-shifting diodes are switched to their non-conducting state, with a view to increasing the switchover speed. This device comprises mainly a low-voltage generator, a circuit breaker or switch, and a high-voltage generator. A switching from the low-voltage generator to the high-voltage generator occurs when the voltage at the terminals of the phase-shifting diode considered exceeds a given threshold value.
摘要翻译： 用于电子扫描天线的二极管相移装置包括设计成当相移二极管切换到其不导通状态时操作的截止装置，以提高切换速度。 该装置主要包括低压发生器，断路器或开关以及高压发生器。 当所考虑的移相二极管的端子处的电压超过给定的阈值时，就会发生从低电压发生器到高电压发生器的切换。
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