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    Reader for conducting assays
    1.
    发明申请
    Reader for conducting assays 审中-公开
    读者进行测定

    公开(公告)号：US20050106746A1

    公开(公告)日：2005-05-19

    申请号：US11009832

    申请日：2004-12-10

    申请人： Alan Shinn ,  Chiko Fan ,  Elias Elias ,  Thomas Novitsky ,  Michael Dawson ,  Keith Richardson

    发明人： Alan Shinn ,  Chiko Fan ,  Elias Elias ,  Thomas Novitsky ,  Michael Dawson ,  Keith Richardson

    IPC分类号： G01N21/25 ,  G01N21/27 ,  G01N21/51 ,  G01N21/53 ,  G01N21/00

    CPC分类号： G01N21/51 ,  G01N21/253 ,  G01N21/272 ,  G01N21/532 ,  Y10T436/11

    摘要： An analytical device that can be used to conveniently and accurately assay plural vessels. In one exemplary embodiment, a pair of LED sources provides illumination through a pair of radial waveguides to plural vessels arranged in a pair of substantially concentric and circular rows about the LED sources. A light pipe receives light transmitted through a vessel from each radial waveguide and reflects the received light downward to a single printed circuit board that contains a photodiode for each light pipe, as well as processing circuitry. The first LED source/radial waveguide optical is used to confirm the presence of a vessel, and the second is used to perform, e.g., turbidometric and/or colorimetric assays upon an analyte within the vessel. The vessel is incubated in a vessel support that includes a heat conducting base and a heat insulating cover. Heat is supplied by a DC heater.

    摘要翻译： 可用于方便，准确地测定多个血管的分析装置。 在一个示例性实施例中，一对LED源通过一对径向波导提供照射到围绕LED源布置在一对基本同心和圆形行中的多个容器。 光管接收从每个径向波导传输通过容器的光，并将接收的光向下反射到包含用于每个光管的光电二极管的单个印刷电路板以及处理电路。 第一个LED源/径向波导光学器件用于确认容器的存在，第二个用于对容器内的分析物进行例如浊度和/或比色测定。 将容器在包括导热基底和隔热盖的容器支架中孵育。 热量由直流加热器供电。

    Reader for conducting assays
    2.
    发明授权
    Reader for conducting assays 失效
    读者进行测定

    公开(公告)号：US06900059B1

    公开(公告)日：2005-05-31

    申请号：US09721973

    申请日：2000-11-27

    申请人： Alan Shinn ,  Chiko Fan ,  Elias R. Elias ,  Thomas J. Novitsky ,  Michael Dawson ,  Keith Richardson

    发明人： Alan Shinn ,  Chiko Fan ,  Elias R. Elias ,  Thomas J. Novitsky ,  Michael Dawson ,  Keith Richardson

    IPC分类号： G01N21/25 ,  G01N21/27 ,  G01N21/51 ,  G01N21/53

    CPC分类号： G01N21/51 ,  G01N21/253 ,  G01N21/272 ,  G01N21/532 ,  Y10T436/11

    摘要： An analytical device that can be used to conveniently and accurately assay plural vessels. In one exemplary embodiment, a pair of LED sources provides illumination through a pair of radial waveguides to plural vessels arranged in a pair of substantially concentric and circular rows about the LED sources. A light pipe receives light transmitted through a vessel from each radial waveguide and reflects the received light downward to a single printed circuit board that contains a photodiode for each light pipe, as well as processing circuitry. The first LED source/radial waveguide optical is used to confirm the presence of a vessel, and the second is used to perform, e.g., turbidometric and/or calorimetric assays upon an analyte within the vessel. The vessel is incubated in a vessel support that includes a heat conducting base and a heat insulating cover. Heat is supplied by a DC heater.

    摘要翻译： 可用于方便，准确地测定多个血管的分析装置。 在一个示例性实施例中，一对LED源通过一对径向波导提供照射到围绕LED源布置在一对基本同心和圆形行中的多个容器。 光管接收从每个径向波导传输通过容器的光，并将接收的光向下反射到包含用于每个光管的光电二极管的单个印刷电路板以及处理电路。 第一个LED源/径向波导光学器件用于确认容器的存在，第二个用于对容器内的分析物进行例如浊度和/或量热分析。 将容器在包括导热基底和隔热盖的容器支架中孵育。 热量由直流加热器供电。

    Collapsible apparatus for compressing packing material in liquid chromatography columns and methods of use
    8.
    发明授权
    Collapsible apparatus for compressing packing material in liquid chromatography columns and methods of use 失效
    用于压缩液相色谱柱中的包装材料的折叠装置和使用方法

    公开(公告)号：US6001260A

    公开(公告)日：1999-12-14

    申请号：US868252

    申请日：1997-06-03

    申请人： Richard G. Hatch ,  Chiko Fan

    发明人： Richard G. Hatch ,  Chiko Fan

    IPC分类号： G01N30/56 ,  B01D15/08 ,  B01D15/20 ,  B01D15/22 ,  G01N30/52 ,  G01N30/60

    CPC分类号： B01D15/206 ,  B01D15/20 ,  B01D15/22 ,  G01N2030/522 ,  G01N30/56 ,  G01N30/6004

    摘要： Longitudinally collapsible apparatus for compacting packing material within a tubular liquid chromatography column. The apparatus includes a first support member, a second support member and a movable support member. The movable support member is releasably connectable to the second support member for support thereby. When released from the second support member, the movable member is adapted to ride on guide members extending between the first and second support members. A compression mechanism is supported on the movable support member to move therewith to a longitudinally collapsed position for the apparatus. The compression mechanism comprises a reversible drive for an axially movable rod carrying a movable piston. With the movable support member secured to the second support member, the piston of the compression mechanism is movable in an end of the tubular column when the column is supported on the first support member. Movement of the movable piston within the column axially compresses a column packing material as the piston is driven towards an opposite end of the column. The piston also is releasably connectable to the tubular column to raise and lower the column when the apparatus extends in a vertical direction and is it is desired to insert an end piston into or remove the end piston from the opposite end of the column or when it is desired to change an adapter ring on the first support member to receive a column of a different diameter for packing by the apparatus.

    摘要翻译： 用于压缩管状液相色谱柱内的包装材料的纵向可折叠装置。 该装置包括第一支撑构件，第二支撑构件和可动支撑构件。 可移动支撑构件可释放地连接到用于支撑的第二支撑构件。 当从第二支撑构件释放时，可移动构件适于骑在在第一和第二支撑构件之间延伸的引导构件上。 压缩机构被支撑在可移动支撑构件上以随着其移动到用于装置的纵向收缩位置。 压缩机构包括用于承载活动活塞的可轴向移动的杆的可逆驱动。 当可移动支撑件固定到第二支撑构件上时，当柱被支撑在第一支撑构件上时，压缩机构的活塞可在管柱的端部移动。 当活塞朝向柱的相对端驱动时，柱内的可移动活塞的移动轴向压缩柱填充材料。 当装置在垂直方向上延伸时，活塞也可释放地连接到管状柱体，以升高和降低柱体，并且期望将端部活塞从柱的相对端插入或移出端部活塞，或者当其 期望改变第一支撑构件上的适配环以接收不同直径的柱，以便由该装置包装。

    Multichannel pump apparatus with microflow rate capability
    10.
    发明授权
    Multichannel pump apparatus with microflow rate capability 失效
    具有微流量能力的多通道泵装置

    公开(公告)号：US5253981A

    公开(公告)日：1993-10-19

    申请号：US847654

    申请日：1992-03-05

    申请人： Frank J. Yang ,  Chiko Fan

    发明人： Frank J. Yang ,  Chiko Fan

    IPC分类号： F04B9/04 ,  F04B23/06 ,  F04B49/06 ,  F04B49/20 ,  F04B53/14 ,  G01N30/02 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  F04B41/05 ,  F04B49/08

    CPC分类号： G01N30/36 ,  F04B23/06 ,  F04B49/065 ,  F04B49/20 ,  F04B53/147 ,  F04B9/047 ,  G01N2030/322 ,  G01N2030/326 ,  G01N2030/328 ,  G01N2030/342 ,  G01N2030/347 ,  G01N30/02 ,  G01N30/34

    摘要： A multichannel pump system for HPLC and other uses has a plurality of fluid pumps whose input is fed separately to at least one high pressure mixing unit downstream of the pumps and any associated items such as pulse dampeners and pressure transducers. A pump controller is connected to control each of the pumps separately in a coordinated manner to provide a plurality of operational modes. The operational modes include an isocratic mode, in which optionally the output of solvent of like composition from two or more pumps is pooled to provide increased output capacity, as well as binary, ternary, etc., gradient modes in which different solvents are selectively mixed before being applied to an analytical unit such as an HPLC column. The pump system further includes a novel linear drive pump having interchangeable piston modules providing different ranges of flow rates. The linear drive pump is capable of providing precise solvent delivery at high pressure for flow rates from 20 ml/minute down to 0.0001 ml/minute, and is particularly useful because of its microflow gradient elution capability.

    摘要翻译： 用于HPLC和其它用途的多通道泵系统具有多个流体泵，其输入被分别供给到泵下游的至少一个高压混合单元以及诸如脉冲阻尼器和压力换能器的任何相关物品。 泵控制器被连接以以协调的方式分别控制每个泵以提供多个操作模式。 操作模式包括等度模式，其中可选地从两个或多个泵输出相似组成的溶剂的输出以提供增加的输出容量，以及二元，三元等梯度模式，其中不同的溶剂被选择性地混合 之后应用于诸如HPLC柱的分析单元。 该泵系统还包括具有提供不同流量范围的可互换活塞模块的新型线性驱动泵。 线性驱动泵能够在高压下提供精确的溶剂输送，流速从20ml /分钟下降到0.0001ml /分钟，并且由于其微流量梯度洗脱能力而特别有用。