公开(公告)号：US20120009608A1

公开(公告)日：2012-01-12

申请号：US12832608

申请日：2010-07-08

Applicant: Barbara BOTTAZZI ,  Alberto Mantovani ,  Tiziano Barbui ,  Alessandro Rambaldi

Inventor： Barbara BOTTAZZI ,  Alberto Mantovani ,  Tiziano Barbui ,  Alessandro Rambaldi

IPC: G01N33/543 ,  G01N33/566

CPC classification number: G01N33/6893 ,  G01N2800/22 ,  G01N2800/222 ,  G01N2800/52

Abstract: The invention provides a method for monitoring the progression of a myeloproliferative disease, particularly Polycythemia Vera (PV) and Essential Thrombocythemia (ET), or the response to pharmacological treatment with JAK2 inhibitors in a patient diagnosed positive for the same disease, or a method for predicting thrombotic events in a patient affected by the same myeloproliferative diseases, based on the measurement of PTX3 concentration in a blood, plasma or serum sample.

Abstract translation: 本发明提供了一种用于监测骨髓增生性疾病，特别是红细胞增多症（PV）和基础性血小板增多症（ET）进展的方法，或对于同一疾病诊断为阳性的患者中用JAK2抑制剂进行药理学治疗的反应或方法 基于血液，血浆或血清样品中PTX3浓度的测量，预测受相同骨髓增生性疾病影响的患者的血栓形成事件。

公开(公告)号：US07915004B2

公开(公告)日：2011-03-29

申请号：US11587528

申请日：2005-04-27

Applicant: Alberto Mantovani ,  Giuseppe Peri

Inventor： Alberto Mantovani ,  Giuseppe Peri

IPC: C07K16/18 ,  C12N5/16 ,  G01N33/53 ,  G01N33/535 ,  G01N33/545 ,  G01N33/577 ,  C12P21/08

CPC classification number: G01N33/6893 ,  G01N2333/47

Abstract: Method for determining the level of PTX3 protein in a sample of a biological fluid; hybridoma capable of producing a rat anti-PTX3 monoclonal antibody where said hybridoma is selected from the group comprising MNB10 and Pen-3; specific anti-PTX3 rat monoclonal antibody selected from the monoclonal antibodies produced by the hybridomas MNB10 and Pen-3; kit for determining the level of PTX3 protein in a biological fluid wherein the said kit includes a rat anti-PTX3 monoclonal antibody.

Abstract translation: 用于测定生物流体样品中PTX3蛋白水平的方法; 能够产生大鼠抗PTX3单克隆抗体的杂交瘤，其中所述杂交瘤选自MNB10和Pen-3; 选自由杂交瘤MNB10和Pen-3产生的单克隆抗体的特异性抗PTX3大鼠单克隆抗体; 用于确定生物流体中PTX3蛋白水平的试剂盒，其中所述试剂盒包括大鼠抗PTX3单克隆抗体。

公开(公告)号：US20110055746A1

公开(公告)日：2011-03-03

申请号：US12600239

申请日：2008-05-08

Applicant: Alberto Mantovani ,  Craig Oberlin

Inventor： Alberto Mantovani ,  Craig Oberlin

IPC: G06F3/048

CPC classification number: G02B27/017 ,  B63C11/26 ,  G02B2027/014

Abstract: Devices and systems are provided which may be used to navigate and communicate while diving in dive sites and improve the safety of the diving experience. For example, in certain embodiments, a diver area system is provided which utilizes virtual underwater information to provide the user with their location, the location of other divers (or “buddies”), and/or location of a surface object (e.g., a dive boat). In certain embodiments, the devices and systems disclosed herein may provide user with their location relative to one or more buddies. The user can thus navigate intelligently throughout the dive site and track the location of their buddies which can improve dive safety and/or efficiency. Additionally, the user can communicate with one or more buddy divers and/or surface-based objects and individuals using embodiments of the disclosure.

Abstract translation: 提供了设备和系统，可用于在潜水中潜水时进行导航和通信，并提高潜水体验的安全性。 例如，在某些实施例中，提供了一种潜水员区域系统，其利用虚拟的水下信息来向用户提供他们的位置，其他潜水者（或“伙伴”）的位置和/或表面对象的位置（例如， 潜水艇）。 在某些实施例中，本文公开的设备和系统可以向用户提供相对于一个或多个伙伴的位置。 因此，用户可以在整个潜水站点智能地导航，并跟踪其伙伴的位置，这可以提高潜水安全性和/或效率。 另外，用户可以使用本公开的实施例与一个或多个伙伴潜水员和/或基于表面的对象和个人进行通信。

公开(公告)号：US07858755B2

公开(公告)日：2010-12-28

申请号：US10893485

申请日：2004-07-16

Applicant: Valerie Wittamer ,  Jean-François Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel LePoul ,  Cecile Loison ,  Frédéric Ooms

Inventor： Valerie Wittamer ,  Jean-François Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel LePoul ,  Cecile Loison ,  Frédéric Ooms

IPC: C07K16/00

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/575 ,  C07K16/18 ,  C07K16/28 ,  G01N33/74 ,  G01N2500/02

Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.

Abstract translation: 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。

公开(公告)号：US20060286617A1

公开(公告)日：2006-12-21

申请号：US11508960

申请日：2006-08-24

Applicant: Roberto Latini ,  Giuseppi Peri ,  Alberto Mantovani ,  Aldo Maggioni

Inventor： Roberto Latini ,  Giuseppi Peri ,  Alberto Mantovani ,  Aldo Maggioni

IPC: G01N33/53 ,  C12M1/34

CPC classification number: G01N33/6893 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/325

Abstract: A method for the early determination of the risk of death or heart failure in infarction patients, and the risk of death, relapse or complications in ictus patients, the method being based on the determination of PTX3 from plasma or blood.

公开(公告)号：US20060024750A1

公开(公告)日：2006-02-02

申请号：US11134811

申请日：2005-05-20

Applicant: Valeria Wittamer ,  J.F. Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franseen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel Le Poul

Inventor： Valeria Wittamer ,  J.F. Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franseen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel Le Poul

IPC: G01N33/53

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/575 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/34 ,  G01N2500/02

Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.

Abstract translation: 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。

公开(公告)号：US06529598B1

公开(公告)日：2003-03-04

申请号：US09312178

申请日：1999-05-14

Applicant: Frank Sacca ,  Alberto Mantovani ,  James Bunde Villadsen Skov

Inventor： Frank Sacca ,  Alberto Mantovani ,  James Bunde Villadsen Skov

IPC: H04M1100

CPC classification number: H04M11/06

Abstract: The line interface circuit of a modem to be connected to a standard RJ11 jack of a digital PBX (Private Branch Exchange) is used along with software routines resident in the modem to detect the presence of a PBX connected to the modem. Upon going off-hook, the modem, by the software routines, determines whether the connection will harm the interface by one of several software routines. If it appears that the interface circuit may be damaged because a PBX line is present, the modem is instructed to go on-hook (hang up), or if the connection is not harmful to the interface, alerts the user that the modem is connected to a wrong jack.

Abstract translation: 要连接到数字PBX（专用交换机）的标准RJ11插孔的调制解调器的线路接口电路与驻留在调制解调器中的软件例程一起使用，以检测连接到调制解调器的集团电话的存在。 摘机时，调制解调器通过软件程序确定连接是否会通过几个软件例程之一对接口造成伤害。 如果看起来接口电路可能因为PBX线路而被损坏，则指示调制解调器进行挂机（挂断），或者如果连接对接口无害，则向用户通知调制解调器已连接 一个错误的杰克。

公开(公告)号：US08003347B2

公开(公告)日：2011-08-23

申请号：US12184783

申请日：2008-08-01

Applicant: Valeria Wittamer ,  Jean-Francois Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel Lepoul

Inventor： Valeria Wittamer ,  Jean-Francois Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Silvano Sozzani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel Lepoul

IPC: C12N15/00 ,  C12N15/85 ,  C12N15/19 ,  C07H21/04 ,  C07K14/52

CPC classification number: C07K14/475 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/705 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/34 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/02

Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.

Abstract translation: 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。

公开(公告)号：US08003109B2

公开(公告)日：2011-08-23

申请号：US11882180

申请日：2007-07-31

Applicant: Barbara Bottazzi ,  Martino Introna ,  Alberto Mantovani ,  Annunciata Vecchi

Inventor： Barbara Bottazzi ,  Martino Introna ,  Alberto Mantovani ,  Annunciata Vecchi

IPC: A61K39/00

CPC classification number: A61K38/1709 ,  A61K48/00 ,  C07K14/47 ,  C07K14/71 ,  Y02A50/481

Abstract: Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumor diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumors.

Abstract translation: 描述的药物组合物含有长的pentraxin PTX3，特别是人PTX3，用于治疗感染性和炎性或肿瘤疾病; 含有编码PTX3的cDNA的表达载体; 用这些载体转染的重组宿主细胞; 用于生产涉及培养这种细胞的大量PTX3的方法，以及所述载体在肿瘤基因治疗中的用途。

公开(公告)号：US20110033467A1

公开(公告)日：2011-02-10

申请号：US12389349

申请日：2009-02-19

Applicant: Valerie Wittamer ,  J. F. Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel Le Poul ,  Cecile Loison ,  Frederic Ooms ,  Silvano Sozzani

Inventor： Valerie Wittamer ,  J. F. Mirjolet ,  Isabelle Migeotte ,  David Communi ,  Alberto Mantovani ,  Marisa Vulcano ,  Jean-Denis Franssen ,  Stephane Brezillon ,  Michel Detheux ,  Gilbert Vassart ,  Marc Parmentier ,  Emmanuel Le Poul ,  Cecile Loison ,  Frederic Ooms ,  Silvano Sozzani

IPC: A61K39/395 ,  C12P21/00

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/575 ,  C07K16/18 ,  C07K16/28 ,  G01N33/74 ,  G01N2500/02

Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.

Abstract translation: 本发明涉及G蛋白偶联受体及其新型配体。 本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。