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公开(公告)号：US20050164362A1
公开(公告)日：2005-07-28
申请号：US10872770
申请日：2004-06-21
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Matthew Kimber , Benjamin Pinder , Francois Vallee , Olga Wrezel , Donald Awrey , Bryan Beattie
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Matthew Kimber , Benjamin Pinder , Francois Vallee , Olga Wrezel , Donald Awrey , Bryan Beattie
CPC分类号： C12N9/18 , C07K14/21 , C07K2299/00
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
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公开(公告)号：US20050221462A1
公开(公告)日：2005-10-06
申请号：US10965006
申请日：2004-10-14
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Megan Domagala , Matthew Kimber , Francois Vallee
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Megan Domagala , Matthew Kimber , Francois Vallee
CPC分类号： C12N9/88 , C07K2299/00 , C12Q1/18 , G16B15/00 , G16B20/00
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译： 本发明涉及病原菌的新型药物靶标。 因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。
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公开(公告)号：US20050214773A1
公开(公告)日：2005-09-29
申请号：US10806062
申请日：2004-03-22
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Robert Lam , Qin Li , Kathleen Nethery-Brokx , Ivy Ng , Benjamin Pinder , Cristina Viola , Olga Wrezel , Dhushy Kanagarajah , Kamran Mansoury , Sasha Necakov , Francois Vallee , Merry-Lynn McDonald
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Megan Domagala , Simon Houston , Robert Lam , Qin Li , Kathleen Nethery-Brokx , Ivy Ng , Benjamin Pinder , Cristina Viola , Olga Wrezel , Dhushy Kanagarajah , Kamran Mansoury , Sasha Necakov , Francois Vallee , Merry-Lynn McDonald
IPC分类号： A61K38/00 , C07K14/205 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/315 , C12N9/00 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/80 , G01N33/569 , C12Q1/68 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C07K14/205 , A61K38/00 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/3156 , C07K2299/00 , C07K2319/00 , C12N9/0006 , C12N9/1077 , C12N9/1085 , C12N9/1205 , C12N9/1217 , C12N9/1229 , C12N9/1241 , C12N9/80 , C12N9/93 , C12Y207/01026 , C12Y207/01069 , C12Y207/02003 , C12Y207/07003 , C12Y601/01001 , C12Y601/0101 , C12Y601/01021 , G01N33/56911 , G01N33/56938 , G01N33/56944
摘要： The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
摘要翻译： 本发明涉及致病细菌的多肽靶标。 本发明还提供那些多肽的生物化学和生物物理学特征。
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公开(公告)号：US20050181388A1
公开(公告)日：2005-08-18
申请号：US10958216
申请日：2004-10-04
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Cheryl Arrowsmith , Donald Awrey , Bryan Beattie , Kristina Buzadzija , Veronica Canadien , Megan Domagala , Simon Houston , Dhushy Kanagarajah , Qin Li , Kamran Mansoury , Merry-Lynn McDonald , Kathleen Nethery-Brokx , Ivy Ng , Hui Ouyang , Benjamin Pinder , Dawn Richards , Matthew Tai , Rosanne Thalakada , Francois Vallee , Cristina Virag
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Cheryl Arrowsmith , Donald Awrey , Bryan Beattie , Kristina Buzadzija , Veronica Canadien , Megan Domagala , Simon Houston , Dhushy Kanagarajah , Qin Li , Kamran Mansoury , Merry-Lynn McDonald , Kathleen Nethery-Brokx , Ivy Ng , Hui Ouyang , Benjamin Pinder , Dawn Richards , Matthew Tai , Rosanne Thalakada , Francois Vallee , Cristina Virag
IPC分类号： C07K14/245 , C07K14/315 , C07K14/32 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/16 , C12N9/78 , C12N9/90 , C12Q1/68 , G01N33/00
CPC分类号： C12N9/0008 , C07K14/245 , C07K14/3156 , C07K14/32 , C07K2319/00 , C12N9/0006 , C12N9/1007 , C12N9/1077 , C12N9/1085 , C12N9/1205 , C12N9/1229 , C12N9/1235 , C12N9/1241 , C12N9/14 , C12N9/16 , C12N9/78 , C12N9/90 , C12N9/93 , C12Y101/01158 , C12Y102/01011 , C12Y201/01033 , C12Y201/01045 , C12Y201/01061 , C12Y204/02007 , C12Y205/01007 , C12Y207/01026 , C12Y207/01048 , C12Y207/04008 , C12Y207/06001 , C12Y207/07003 , C12Y207/07023 , C12Y207/07038 , C12Y304/11018 , C12Y304/24057 , C12Y305/04005 , C12Y306/01001 , C12Y501/03001 , C12Y504/02003 , C12Y599/01003 , C12Y601/01014 , C12Y601/0102 , C12Y601/01021 , C12Y603/02004 , C12Y603/02008 , C12Y603/02013 , C12Y603/04014 , C12Y604/01002
摘要： The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
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公开(公告)号：US20050181464A1
公开(公告)日：2005-08-18
申请号：US10953901
申请日：2004-09-29
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Cheryl Arrowsmith , Donald Awrey , Bryan Beattie , Kristina Buzadzija , Teresa Clarke , Megan Domagala , Simon Houston , Dhushy Kanagarajah , Qin Li , Kamran Mansoury , Merry-Lynn McDonald , Kathleen Nethery-Brokx , Ivy Ng , Hui Ouyang , Dawn Richards , Francois Vallee , Cristina Virag
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Muhammad Alam , Cheryl Arrowsmith , Donald Awrey , Bryan Beattie , Kristina Buzadzija , Teresa Clarke , Megan Domagala , Simon Houston , Dhushy Kanagarajah , Qin Li , Kamran Mansoury , Merry-Lynn McDonald , Kathleen Nethery-Brokx , Ivy Ng , Hui Ouyang , Dawn Richards , Francois Vallee , Cristina Virag
IPC分类号： B01D15/38 , C07K14/205 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/315 , C12N1/06 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/12 , C12N9/48 , C12N9/78 , C12N9/88 , C12N9/90 , G01N33/554 , C07K14/195 , G01N33/00 , G01N33/569
CPC分类号： C12N9/0016 , B01D15/3804 , C07K14/205 , C07K14/21 , C07K14/245 , C07K14/31 , C07K14/315 , C07K14/3156 , C12N1/06 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1029 , C12N9/1205 , C12N9/1247 , C12N9/1252 , C12N9/1288 , C12N9/48 , C12N9/78 , C12N9/88 , C12N9/90 , C12N9/93
摘要： The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
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公开(公告)号：US20050245728A1
公开(公告)日：2005-11-03
申请号：US10967671
申请日：2004-10-18
申请人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Matthew Kimber , Francois Vallee
发明人： Aled Edwards , Akil Dharamsi , Masoud Vedadi , Matthew Kimber , Francois Vallee
CPC分类号： C12N9/1085 , C07K2299/00 , C12Q1/18 , G01N2333/21
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译： 本发明涉及病原菌的新型药物靶标。 因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。
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7.发明授权Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90 有权芴衍生物，含有该衍生物的组合物及其作为蛋白质分子伴侣HSP90抑制剂的用途公开(公告)号：US08163750B2
公开(公告)日：2012-04-24
申请号：US12625005
申请日：2009-11-24
申请人： Fabienne Thompson , Patrick Mailliet , Jean-Marie Ruxer , Helene Goulaouic , Francois Vallee , Herve Minoux , Fabienne Pilorge , Luc Bertin , Stephane Hourcade , Maria Mendez-Perez , Peter Hamley
发明人： Fabienne Thompson , Patrick Mailliet , Jean-Marie Ruxer , Helene Goulaouic , Francois Vallee , Herve Minoux , Fabienne Pilorge , Luc Bertin , Stephane Hourcade , Maria Mendez-Perez , Peter Hamley
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D403/12 , C07D401/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I): wherein R1, R2, R2′, L, Het, p and p′ are as defined herein, compositions containing them, and their use as medicinal products.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，R2'，L，Het，p和p'如本文所定义，含有它们的组合物及其作为药用产品的用途。
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