公开(公告)号：US20120209069A1

公开(公告)日：2012-08-16

申请号：US13502412

申请日：2010-10-04

申请人： Aleksandra Popovic ,  Mareike Klee ,  Bout Marcelis ,  Christianus Martinus Van Heesch

发明人： Aleksandra Popovic ,  Mareike Klee ,  Bout Marcelis ,  Christianus Martinus Van Heesch

IPC分类号： A61B1/00 ,  A61B1/04

CPC分类号： A61B5/065 ,  A61B1/00147 ,  A61B1/00149 ,  A61B1/00193 ,  A61B34/30 ,  A61B2034/105 ,  A61B2034/301 ,  A61B2090/062 ,  A61B2090/08021 ,  A61B2090/3614 ,  A61B2090/367 ,  A61B2090/3784 ,  A61B2090/506 ,  G06T7/579 ,  G06T2207/10068 ,  G06T2207/30004

摘要： An endoscopic method involves an advancement of an endoscope (20) as controlled by an endoscopic robot (31) to a target location within an anatomical region of a body, and a generation of a plurality of monocular endoscopic images (80) of the anatomical region as the endoscope (20) is advanced to the target location by the endoscopic robot (31). For avoiding or detecting a collision of the endoscope (20) with and object within monocular endoscopic images (80) (e.g., a ligament within monocular endoscopic images of a knee), the method further involves a generation of distance measurements of the endoscope (20) from the object as the endoscope (20) is advanced to the target location by the endoscopic robot (31), and a reconstruction of a three-dimensional image of a surface of the object within the monocular endoscopic images (80) as a function of the distance measurements (81).

摘要翻译： 内窥镜方法包括将内窥镜机器人（31）控制的内窥镜（20）推进到身体的解剖区域内的目标位置，以及生成解剖区域的多个单目内窥镜图像（80） 当内窥镜（20）通过内窥镜机器人（31）前进到目标位置时。 为了避免或检测内窥镜（20）与单眼内窥镜图像（80）（例如膝盖的单眼内窥镜图像内的韧带）的对象的碰撞，该方法还包括生成内窥镜（20）的距离测量 ）由内窥镜（20）通过内窥镜机器人（31）前进到目标位置，并且将单眼内窥镜图像（80）内的物体的表面的三维图像重建为功能 的距离测量（81）。

公开(公告)号：US20110245713A1

公开(公告)日：2011-10-06

申请号：US13127046

申请日：2009-11-09

申请人： Judith Margreet Rensen ,  Jaap Haartsen ,  Mareike Klee ,  Drazenko Babic ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Christianus Martinus Van Heesch ,  Bout Marcelis

发明人： Judith Margreet Rensen ,  Jaap Haartsen ,  Mareike Klee ,  Drazenko Babic ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Christianus Martinus Van Heesch ,  Bout Marcelis

IPC分类号： A61B5/01

CPC分类号： G01K13/002 ,  A61B5/01 ,  A61B2562/0271 ,  G01K3/14 ,  G01K7/02

摘要： A medical device comprising a probe for measurement temperature data of tissue within a patient's body is proposed. The probe (2) comprises a flexible substrate (3) attached to a medical device core (5), the flexible substrate (3) comprising one or more thermopiles (7) and may furthermore comprise resistors for measuring an absolute temperature and heat sources for locally applying heat. The thermopiles can be processed directly on a flexible polymer carrier or, alternatively, on a silicon substrate and transferred to a flexible carrier (3) enabling both, a highly flexible substrate (3) and very small structural dimensions for the thermopiles (7) and, possibly, the resistors and heat sources. Accordingly, measurement of temperature gradients of tissue being in contact to the medical device may be performed at high resolution allowing reliable detection of temperature anomalies e.g. due to malign tissue.

摘要翻译： 提出了包括用于测量患者身体内的组织的温度数据的探针的医疗装置。 探针（2）包括附接到医疗器件芯（5）的柔性衬底（3），柔性衬底（3）包括一个或多个热电堆（7），并且还可以包括用于测量绝对温度的电阻器和用于 局部施加热量。 可以将热电堆直接加工在柔性聚合物载体上，或者在硅衬底上进行处理，并转移到柔性载体（3）上，从而使高弹性基底（3）和热电堆（7）的非常小的结构尺寸和 ，可能是电阻和热源。 因此，可以以高分辨率执行与医疗装置接触的组织的温度梯度的测量，从而可以可靠地检测温度异常。 由于恶性组织。

公开(公告)号：US20120085934A1

公开(公告)日：2012-04-12

申请号：US13378068

申请日：2010-06-17

申请人： Bout Marcelis ,  Christianus Martinus Van Heesch ,  Mareike Klee ,  Drazenko Babic

发明人： Bout Marcelis ,  Christianus Martinus Van Heesch ,  Mareike Klee ,  Drazenko Babic

IPC分类号： G01N23/00 ,  G01S15/06 ,  G01N21/00

CPC分类号： G01S5/18 ,  G01S15/876 ,  G01S2013/468 ,  G01S2015/465

摘要： The invention relates to position determining system (201) for determining a position of an object (2). A first position detection unit (205) detects a first position of the object (2) based on radiation transferred between the object (2) and transfer positions being known relative to a reference position by a sending and receiving unit (203, 214, 216, 217). A second position detection unit (35) detects a second position based on an acceleration of the object (2) and the determined first position, wherein an output unit (12) outputs at least one of the first position and the second position. If the transfer of radiation is interrupted, the second position can be output by the output unit. Moreover, the first position can be used as an initial value for determining the second position or to update the second position. This improves the quality of determining the position of the object.

摘要翻译： 本发明涉及一种用于确定物体（2）的位置的位置确定系统（201）。 第一位置检测单元（205）基于通过发送和接收单元（203,214,216）在对象（2）和相对于参考位置已知的传送位置之间传送的辐射来检测对象（2）的第一位置 ，217）。 第二位置检测单元（35）基于物体（2）的加速度和确定的第一位置来检测第二位置，其中输出单元（12）输出第一位置和第二位置中的至少一个。 如果辐射传输中断，则第二位置可以由输出单元输出。 此外，第一位置可以用作用于确定第二位置的初始值或者更新第二位置。 这提高了确定对象位置的质量。

公开(公告)号：US20120296224A1

公开(公告)日：2012-11-22

申请号：US13521768

申请日：2011-01-10

申请人： Mareike Klee ,  Christianus Martinus Van Heesch ,  Dirk Jan Broer ,  Jacob Roger Haartsen

发明人： Mareike Klee ,  Christianus Martinus Van Heesch ,  Dirk Jan Broer ,  Jacob Roger Haartsen

IPC分类号： A61B5/026

CPC分类号： A61B5/026 ,  A61B5/413 ,  A61B5/6833 ,  A61B5/6876 ,  A61B5/6884 ,  A61B2560/0412

摘要： The present invention relates to determining or measuring a biological, physical or physiological parameter of an object (10) by a sensor (2). It may be beneficial to constantly monitor or determine a biological, physical or physiological parameter of an object (10) by a sensor (2), subsequently allowing for a preferred removal of the sensor (2) from object (10) when the monitoring is no longer required. Accordingly, a sensor (2) is provided, e.g. a flow sensor, employing a degradable adhesive (8) for attachment of the sensor (2) to the object (10). The degradable adhesive (8) may be degradable e.g. by time, by exposure to a certain measure, e.g. induced heat, or substance for detaching the sensor (2) from the object (10) for subsequent removal of the sensor (2).

摘要翻译： 本发明涉及通过传感器（2）来确定或测量物体（10）的生物，物理或生理参数。 通过传感器（2）持续地监测或确定物体（10）的生物，物理或生理参数可能是有益的，随后允许当监测是（...）时将传感器（2）从对象（10）中移除， 不再需要。 因此，提供传感器（2），例如 流量传感器，使用用于将传感器（2）附接到物体（10）的可降解粘合剂（8）。 可降解粘合剂（8）可以是降解的。 通过暴露于某种措施，例如， 感应的热量或用于将传感器（2）从物体（10）分离以用于随后去除传感器（2）的物质。

公开(公告)号：US20110137166A1

公开(公告)日：2011-06-09

申请号：US13058370

申请日：2009-08-10

申请人： Mareike Klee ,  Michael Harald Kuhn ,  Karen Irene Trovato ,  Christianus Martinus Van Heesch ,  Ruediger Mauczok ,  Marco De Wild ,  Biju Kumar Sreedharan Nair ,  Klaus Reimann

发明人： Mareike Klee ,  Michael Harald Kuhn ,  Karen Irene Trovato ,  Christianus Martinus Van Heesch ,  Ruediger Mauczok ,  Marco De Wild ,  Biju Kumar Sreedharan Nair ,  Klaus Reimann

IPC分类号： A61B8/00

CPC分类号： A61B8/485 ,  A61B8/4281 ,  A61B8/4416 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/4494 ,  A61B2562/0204 ,  A61B2562/164 ,  B06B1/0292 ,  G01H11/06 ,  G10K9/125

摘要： The present invention relates to a transducer arrangement, particularly a transducer arrangement for acquiring tissue information, a method for using a transducer arrangement for acquiring tissue information and a glove which comprises a transducer arrangement. The transducer arrangement 21 for analysing material 40 comprises: a first transducer element 51 for inducing and receiving mechanical displacements in the material to be analysed 40; and an analysing unit 30. The transducer arrangement is arranged such as to be flexible in order to conform with a curved surface of the material to be analysed 40; and the transducer arrangement 21 is adapted to derive a first signal from a low frequency spectrum of mechanical displacements which first signal correlates to sono-elastographical properties of a material to be analysed 40; and the transducer arrangement 21 is adapted to derive a second signal from a high frequency spectrum of mechanical displacements received by the first transducer element 51 which second signal correlates to ultrasonic properties of a material to be analysed 40. With a transducer arrangement according to the invention it may be possible to generate information about the topographical anatomy and information about elastical properties of the material to be analyzed in parallel, whereby the transducer arrangement may be adapted to the unevenness of the material's surface optimally due to its flexibility which may allow the examiner or user of the transducer arrangement to analyze regions which normally may have an uneven surface profile, which may only be reached with difficulty or whose examination may cause inconvenience to the examiner as well as to the person that is being examined.

摘要翻译： 本发明涉及一种换能器装置，特别是一种用于获取组织信息的换能器装置，一种使用换能器装置来获取组织信息的方法和一种包括换能器装置的手套。 用于分析材料40的换能器装置21包括：用于诱导和接收待分析材料40中的机械位移的第一换能器元件51; 和分析单元30.换能器装置布置成柔性以便与要分析的材料40的曲面一致; 并且换能器装置21适于从低频谱的机械位移导出第一信号，第一信号与要分析的材料40的声弹性特性相关; 并且换能器装置21适于从由第一换能器元件51接收的机械位移的高频谱导出第二信号，第二信号与待分析的材料的超声波属性相关。使用根据本发明的换能器装置 有可能产生关于地形解剖学的信息和关于要分析的材料的弹性特性的信息并行地进行，由此，换能器装置可以由于其灵活性而适应于材料表面的不均匀性，其灵活性可允许检查者或 换能器装置的使用者分析通常可能具有不平坦表面轮廓的区域，其可能只能难以达到或者检查可能对检查者以及被检查者造成不便。

公开(公告)号：US08801623B2

公开(公告)日：2014-08-12

申请号：US13521768

申请日：2011-01-10

申请人： Mareike Klee ,  Christianus Martinus Van Heesch ,  Dirk Jan Broer ,  Jacob Roger Haartsen

发明人： Mareike Klee ,  Christianus Martinus Van Heesch ,  Dirk Jan Broer ,  Jacob Roger Haartsen

IPC分类号： A61B5/00 ,  A61B5/02

CPC分类号： A61B5/026 ,  A61B5/413 ,  A61B5/6833 ,  A61B5/6876 ,  A61B5/6884 ,  A61B2560/0412

摘要： A device and method determining or measuring a biological, physical or physiological parameter of an object includes a flexible carrier configured to be placed in a vicinity of the object; and at least one a sensor element attached to the flexible carrier and configured to determine at least one biological, physical or physiological parameter. In addition, a heating element is attached to the flexible carrier and configured to provide heat to the object; and a degradable adhesive is arranged on the flexible carrier adjacent to the heating element and configured to at least temporally affix the flexible carrier to the object.

摘要翻译： 确定或测量物体的生物，物理或生理参数的装置和方法包括被配置为放置在物体附近的柔性载体; 以及至少一个传感器元件，其附接到所述柔性载体并且被配置为确定至少一个生物，物理或生理参数。 此外，加热元件附接到柔性载体并且被配置为向物体提供热量; 并且可降解粘合剂布置在邻近加热元件的柔性载体上并且被配置为至少在时间上将柔性载体附着到物体上。

公开(公告)号：US20120123270A1

公开(公告)日：2012-05-17

申请号：US13384879

申请日：2010-07-26

申请人： Mareike Klee ,  Christianus Martinus Van Heesch ,  Peter Dirksen ,  Ruediger Mauczok ,  Nico Maris Adriaan De Wild

发明人： Mareike Klee ,  Christianus Martinus Van Heesch ,  Peter Dirksen ,  Ruediger Mauczok ,  Nico Maris Adriaan De Wild

IPC分类号： A61B8/00

CPC分类号： A61B8/12 ,  A61B5/489 ,  A61B5/6848 ,  A61B6/4441 ,  A61B8/06 ,  A61B8/0816 ,  A61B8/445 ,  A61B8/4483 ,  A61B2017/00106 ,  B06B1/0622

摘要： The invention proposes to equip the tip of a surgical instrument such as a needle or catheter or any other instrument with an ultrasound transducer array to measure flow just in front of the tip by means of time and frequency differences between the sent and received pulses. Since no image is required, only a few transducer elements are required. The transducer elements generate a pressure pulses in specific directions and receives its echo's without the use of imaging techniques and complex driving electronics. Using the frequency shift and time delay of the received signals the proximity and lateral direction of the blood flow may be detected, thus identifying blood vessels.

摘要翻译： 本发明提出将诸如针或导管或任何其他器械的手术器械的尖端装备有超声换能器阵列，以通过发送和接收的脉冲之间的时间和频率差来测量刚好在尖端前面的流量。 由于不需要图像，因此只需要几个换能器元件。 传感器元件在特定方向产生压力脉冲，并且不使用成像技术和复杂的驱动电子元件接收其回波。 使用接收信号的频移和时间延迟可以检测血流的接近和横向，从而识别血管。

公开(公告)号：US09827351B2

公开(公告)日：2017-11-28

申请号：US14127508

申请日：2012-06-29

申请人： Dirk Burdinski ,  Joyce Van Zanten ,  Lucas Johannes Anna Maria Beckers ,  Cornelis Petrus Hendriks ,  Willem Franke Pasveer ,  Nicolaas Petrus Willard ,  Mareike Klee ,  Biju Kumar Sreedharan Nair ,  David Smith

发明人： Dirk Burdinski ,  Joyce Van Zanten ,  Lucas Johannes Anna Maria Beckers ,  Cornelis Petrus Hendriks ,  Willem Franke Pasveer ,  Nicolaas Petrus Willard ,  Mareike Klee ,  Biju Kumar Sreedharan Nair ,  David Smith

IPC分类号： A61F13/15 ,  A61L31/06 ,  C08G77/392 ,  C08L83/08 ,  A61F5/00 ,  A61Q19/00 ,  A61K8/895 ,  A61K8/02 ,  A61L31/10 ,  A61L31/14 ,  A61F13/20 ,  C08G77/12

CPC分类号： A61L31/06 ,  A61F5/00 ,  A61F13/2002 ,  A61K8/0208 ,  A61K8/895 ,  A61K2800/10 ,  A61K2800/54 ,  A61L31/10 ,  A61L31/146 ,  A61M2205/02 ,  A61Q19/00 ,  C08G77/12 ,  C08G77/392 ,  C08L83/08

摘要： This invention relates to medical, health care and non-medical devices comprising a rubbery or elastomeric polymer material taking up more than 5% by weight of water and at most 500% by weight of water after immersion in demineralized water at room temperature for a sufficient time to reach saturation. The material may be in the form of a foam, or in the form of a coating adapted for adhesion to a substrate, or in the form of a sheet, or in the form of a fiber, and may comprise: —repeating units from one or more hydrophobic organic monomers, and —repeating units from one or more monomers (a) being modified with one or more hydrophilic side groups.

公开(公告)号：US09188469B2

公开(公告)日：2015-11-17

申请号：US13502386

申请日：2010-10-15

申请人： Mareike Klee ,  Jaap Roger Haartsen

发明人： Mareike Klee ,  Jaap Roger Haartsen

IPC分类号： G01F1/68 ,  G01F1/688 ,  G01F1/696 ,  G01F1/698 ,  G01F1/699

CPC分类号： G01F1/688 ,  G01F1/6882 ,  G01F1/696 ,  G01F1/6986 ,  G01F1/699

摘要： A sensor system for measuring a velocity of a fluid flowing through a channel includes a heating element for heating the fluid. The heating element is provided with a predetermined level of power during operation. The sensor system further includes a primary electronic circuit having a primary resonance frequency which is temperature dependent. The temperature of the primary electronic circuit is determined by heat transferred from the heating element to the fluid flowing through the channel. In addition, the sensor system also includes a transducer arrangement configured to generate a measurement signal indicative of the velocity of the fluid flowing through the channel. The measurement signal is based on the primary resonance frequency.

摘要翻译： 用于测量流过通道的流体的速度的传感器系统包括用于加热流体的加热元件。 在操作期间，加热元件具有预定水平的功率。 传感器系统还包括具有温度依赖性的初级共振频率的初级电子电路。 主电子电路的温度由从加热元件传递到流过通道的流体的热量来确定。 此外，传感器系统还包括被配置为产生指示流过通道的流体的速度的测量信号的换能器装置。 测量信号基于初级共振频率。

公开(公告)号：US20130333563A1

公开(公告)日：2013-12-19

申请号：US14002213

申请日：2012-02-27

申请人： Rainer Hilbig ,  Achim Gerhard Rolf Koerber ,  Mareike Klee ,  Wilco Cornelis Keur

发明人： Rainer Hilbig ,  Achim Gerhard Rolf Koerber ,  Mareike Klee ,  Wilco Cornelis Keur

IPC分类号： C01B13/02

CPC分类号： C01B13/0251 ,  B01D53/047 ,  B01D53/22 ,  B01D53/229 ,  B01D71/024 ,  B01D2256/12 ,  B01D2259/402 ,  B01D2325/027 ,  C01B13/0255 ,  C01B13/0259 ,  C01B13/027 ,  Y02P20/126

摘要： The invention relates to a method of generating oxygen. The method comprises the steps of: intermittently guiding a stream of oxygen comprising gas through at least one adsorption chamber (12) being equipped with an oxygen separation adsorbent (16), thereby defining an adsorption mode and a desorption mode of the at least one adsorption chamber (12), and thereby enriching the oxygen comprising gas with respect to oxygen, guiding the enriched oxygen comprising gas to a primary side of a dense membrane (52), heating the dense membrane(52) to a temperature at which it is permeable for oxygen, generating an oxygen flow through the dense membrane (52) to its secondary side, thereby separating the oxygen from the enriched oxygen comprising gas and forming a stream of oxygen. According to the invention, the invention further comprises the step of guiding at least a part of the generated oxygen through the at least one adsorption chamber (12) being in desorption mode. The method according to the invention allows generating oxygen in a high purity, thereby being energy saving, cost saving and being performable in a compact device.

摘要翻译： 本发明涉及一种产生氧气的方法。 该方法包括以下步骤：间歇地引导包含气体的氧气通过装有氧分离吸附剂（16）的至少一个吸附室（12），从而限定至少一种吸附剂的吸附模式和解吸模式 （12），从而使相对于氧气的包含气体的氧富集，将富含氧气的气体引导到致密膜（52）的初级侧，将致密膜（52）加热至可渗透的温度 用于氧气，产生通过致密膜（52）到其次级侧的氧气流，从而将氧气与富氧的含氧气体分离并形成氧气流。 根据本发明，本发明还包括通过处于解吸模式的至少一个吸附室（12）引导至少一部分产生的氧的步骤。 根据本发明的方法允许产生高纯度的氧，从而在紧凑的装置中节能，成本节约和可执行。