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公开(公告)号：US06309352B1
公开(公告)日：2001-10-30
申请号：US09179791
申请日：1998-10-27
IPC分类号： A61B600
CPC分类号： A61B5/0095 , A61B5/1459 , A61B8/08 , A61B8/0825 , A61B90/36 , A61B2017/00128 , A61F9/008 , A61F9/00821 , A61F2009/00844 , A61F2009/00851 , A61F2009/00897 , A61K49/225 , G01N21/1702
摘要： The present invention is directed to a method/system of for monitoring tissue properties in real time during treatment using optoacoustic imaging system. Optoacoustic monitoring provides a control of the extent of abnormal tissue damage and assures minimal damage to surrounding normal tissues. Such technique can be applied for monitoring and controlling during surgical, therapeutic, and cosmetic procedures performed in various tissues and organs.
摘要翻译： 本发明涉及一种用于使用光声成像系统在治疗期间实时监测组织性质的方法/系统。 光声监测提供对组织损伤异常程度的控制，并确保对周围正常组织的损伤最小。 这种技术可以应用于在各种组织和器官中进行的手术，治疗和美容过程中的监测和控制。
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公开(公告)号：US06498942B1
公开(公告)日：2002-12-24
申请号：US09633597
申请日：2000-08-07
IPC分类号： A61B500
CPC分类号： G01N21/1702 , A61B5/0095 , A61B5/14553 , A61B5/4076 , A61B8/0808
摘要： An optoacoustic apparatus is disclosed which includes a radiation source of pulsed radiation and a probe having a front face to be placed in close proximity to or in contact with a tissue site of an animal body. The probe further includes a plurality of optical fibers terminating at the surface of the front face of the probe and connected at their other end to a pulsed laser. The front face of the probe also has mounted therein or thereon a transducer for detecting an acoustic response from blood in the tissue site to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of venous blood oxygenation.
摘要翻译： 公开了一种光声装置，其包括脉冲辐射的辐射源和具有被放置在紧邻动物身体的组织部位或与动物身体的组织部位接触的前面的探针。 该探针还包括多个光纤，其终止于探针正面的表面并在其另一端连接到脉冲激光。 探针的前表面还安装有用于检测从组织部位的血液到连接到处理单元的辐射脉冲的声响应的换能器，该处理单元将换能器信号转换为静脉血氧的测量。
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公开(公告)号：US5840023A
公开(公告)日：1998-11-24
申请号：US594758
申请日：1996-01-31
IPC分类号： G01N29/00 , A61B5/00 , A61B8/00 , A61B8/08 , A61B17/00 , A61F9/008 , A61K49/22 , G01N21/00 , G01N21/17
CPC分类号： G01N21/1702 , A61B5/0095 , A61B5/1459 , A61B8/08 , A61F9/008 , A61K49/225 , A61B2017/00128 , A61F2009/00851 , A61F2009/00897
摘要： The laser optoacoustic imaging system described herein utilizes time-resolved measurement of profiles of laser-induced transient pressure (acoustic) waves. The pressure waves are emitted by acoustic sources preferentially generated in absorbing tissues of diagnostic interest. This technique allows visualization of absorbed light distribution in turbid, layered and heterogeneous tissues irradiated by laser pulses in vivo. The laser optoacoustic tomography can be used for the characterization of structure and properties of normal tissue, and for the detection of tissue pathological changes. The optical heterogeneities that can be imaged with the laser optoacoustic imaging system include abnormal tissues such as tumors, injured tissues, blood vessels and other layered tissues. Further, three dimensional images of organs and portions of organs can be obtained.
摘要翻译： 本文描述的激光光声成像系统利用激光诱导瞬态压力（声波）的轮廓的时间分辨测量。 压力波由在诊断感兴趣的吸收组织中优先产生的声源发射。 这种技术允许在体内通过激光脉冲辐射的混浊，分层和异质组织中的吸收光分布的可视化。 激光光声层析成像可用于表征正常组织的结构和性质，并用于检测组织病理变化。 可以用激光光声成像系统成像的光学异质性包括异常组织如肿瘤，损伤组织，血管和其他层状组织。 此外，可以获得器官和器官部分的三维图像。
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4.发明授权Time-resolved optoacoustic method and system for noninvasive monitoring of glucose 有权用于葡萄糖无创监测的时间分辨光声法和系统公开(公告)号：US06405069B1
公开(公告)日：2002-06-11
申请号：US09412852
申请日：1999-10-06
IPC分类号： A61B600
CPC分类号： A61B5/1455 , A61B5/0095 , A61B5/14532 , A61B5/6821 , A61B8/08 , A61B8/0825 , A61B90/36 , A61B2017/00128 , A61F9/008 , A61F2009/00844 , A61F2009/00865 , A61F2009/00897 , A61K49/225 , G01N21/1702
摘要： The present invention is directed to a method/system of monitoring in real time changes in concentration of glucose in tissues. Laser-induced profiles of absorbed optical energy distribution in tissues are determined via measurements of spatial (in-depth) profile of optically-induced acoustic (pressure) transients using a wide-band optoacoustic transducer. Such technique can be applied for monitoring of glucose concentration in various human or nonhuman tissues, cell cultures, solutions or emulsions.
摘要翻译： 本发明涉及一种监测组织中葡萄糖浓度的实时变化的方法/系统。 通过使用宽带光声换能器通过光学诱导的声学（压力）瞬态的空间（深度）分布的测量来确定组织中吸收的光能分布的激光诱导分布。 这种技术可用于监测各种人或非人组织，细胞培养物，溶液或乳剂中的葡萄糖浓度。
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5.发明申请Scanning Optoacoustic Imaging System with High Resolution and Improved Signal Collection Efficiency 审中-公开扫描光学成像系统具有高分辨率和改进的信号采集效率公开(公告)号：US20130190594A1
公开(公告)日：2013-07-25
申请号：US13748315
申请日：2013-01-23
CPC分类号： A61B5/0095 , A61B5/14542 , A61B5/14546 , A61B5/72 , A61B2562/14 , A61B2562/146
摘要： Provided herein are scanning, high-resolution optoacoustic imaging systems or microscopes. Generally, the system/microscope comprises subsystems for scanning a tissue or object therein with a wavelength of electromagnetic energy, such as optical energy, collecting and detecting ultrasonic waves produced when the tissue or object absorbs the incident wavelength and converting the same to an electrical signal, and for processing, analyzing and displaying the electrical signal as a digital image. Specifically, the system/microscope utilizes an off-axis parabolic reflector with a high numerical aperture value for deep tissue visualization. Also, provided is a method for collecting volumetric image data voxel-by-voxel within a subject utilizing the imaging system or microscope. A series of voxels within the scanned tissue produces detectable ultrasonic waves that are collected by the off-axis parabolic reflector and processed as described as a high-resolution image of the tissue or object therein.
摘要翻译： 这里提供扫描，高分辨率光声成像系统或显微镜。 通常，系统/显微镜包括用于扫描具有诸如光能的电磁能波长的组织或物体的子系统，当组织或物体吸收入射波长并将其转换为电信号时收集和检测产生的超声波 并且用于处理，分析和显示作为数字图像的电信号。 具体来说，系统/显微镜利用具有高数值孔径值的离轴抛物面反射器进行深层组织可视化。 此外，提供了一种利用成像系统或显微镜收集受试者内的体素图像数据体素的方法。 扫描的组织内的一系列体素产生可检测的超声波，其由离轴抛物面反射器收集，并如其中组织或物体的高分辨率图像所描述的那样被处理。
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公开(公告)号：US20210030280A1
公开(公告)日：2021-02-04
申请号：US17074371
申请日：2020-10-19
摘要： Provided herein are quantitative optoacoustic tomography systems and methods for dynamic of functional parameters in a subject, for example, to assess conditions of the peripheral vasculature. The system generally has a pulsed laser, a fiberoptic optic bundle light delivery system, and imaging module, an array of ultrawide-band ultrasonic transducers, a circulation system, and electronics/computer system for system control and three-dimensional and two-dimensional optoacoustic image visualization. Also provided is a method for quantitative optoacoustic tomography of an appendage where an appendage of a subject is imaged under conditions of normal, maximum and minimum tolerable temperatures and displaying differential anatomical images of peripheral vasculature in the appendage and functional diagnostic parameters as a function of time and temperature. From this data medical conditions of the appendage may be diagnosed.
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7.发明授权公开(公告)号：US09498133B2
公开(公告)日：2016-11-22
申请号：US14556316
申请日：2014-12-01
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/145 , A61B5/1464 , A61B8/14 , A61B8/08 , A61B8/00
CPC分类号： A61B5/0035 , A61B5/0095 , A61B5/14546 , A61B5/14552 , A61B5/1464 , A61B5/4362 , A61B5/4848 , A61B5/7425 , A61B8/0866 , A61B8/14 , A61B8/4416 , A61B8/4444 , A61B8/5261
摘要： Provided herein are dual modality imaging systems and methods within displayed anatomical structures of placenta in real time. The imaging system comprises a dual modality laser optoacoustic and ultrasonic platform with a plurality of subsystems for delivering near infrared light, optoacoustic and ultrasonic pulses to the placenta and/or associated tissue and deep anatomic structures, for detecting ultrasonic pulses generated or reflected within the tissue using a multi-channel optoacoustic-ultrasound probe and associated transducers. The dual modality imaging system displays the results obtained as quantitative functional images of the parameters coregistered with anatomic tissue images. A multichannel electronic system comprising a computer tangibly storing software enables processor-executable instructions to calculate quantitative functional parameters of the placental blood within specific anatomical tissue structures and display quantitative functional optoacoustic images of the functional parameters within specific anatomical structures in the tissue that are visualized by ultrasound.
摘要翻译： 本文提供了在胎盘显示的解剖结构中实时的双重模态成像系统和方法。 成像系统包括具有多个子系统的双模式激光光声和超声波平台，用于将近红外光，光声和超声脉冲传送到胎盘和/或相关联的组织和深部解剖结构，用于检测组织内产生或反射的超声波脉冲 使用多通道光声超声探头和相关传感器。 双模态成像系统显示获得的结果作为与解剖组织图像核心参数的定量功能图像。 包括有形存储软件的计算机的多通道电子系统使得处理器可执行指令能够计算特定解剖组织结构内的胎盘血液的定量功能参数，并且在组织中的特定解剖结构内显示功能参数的定量功能光声图像，所述功能参数可由 超声波。
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公开(公告)号：US11160456B2
公开(公告)日：2021-11-02
申请号：US13748498
申请日：2013-01-23
摘要： Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system that incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system generates tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system. The method comprises producing an image of an outline boundary of a volume of interest and generating spatially or temporally coregistered images based on speed of sound and/or ultrasonic attenuation and on absorbed optical energy within the outlined volume.
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公开(公告)号：US20210018620A1
公开(公告)日：2021-01-21
申请号：US17063565
申请日：2020-10-05
摘要： Provided herein are imaging systems such as a system for quantitative tomography and a laser optoacoustic ultrasonic imaging system assembly (LOUISA) for imaging a tissue region, for example, a breast, in a subject. Generally, the system components are a laser that emits instant pulses of laser light in a wavelength cycling mode, fiberoptic bundles or optical arc-shaped fiber bundles configured to deliver laser light, an imaging module with an imaging tank, an optoacoustic array(s) of ultrawide-band ultrasonic transducers and ultrasound array(s) of ultrasonic transducers and a coupling medium and an electronics subsystem. Also provided is a method for imaging quantitative functional parameters and/or molecular parameters and anatomical structures in a volumetric tissue region of interest, such as a breast, in a subject utilizing the system for quantitative tomography.
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公开(公告)号：US20150216420A1
公开(公告)日：2015-08-06
申请号：US14611722
申请日：2015-02-02
CPC分类号： A61B5/0095 , A61B5/015 , A61B5/7425 , A61B8/085 , A61B8/14 , A61B8/463 , A61B8/5207 , A61B18/02 , A61B2018/00714 , A61B2018/0293 , A61B2090/378 , A61B2560/0223
摘要： Provided herein are system and methods for monitoring and guiding thermal therapy procedures within a human or animal tissue. The system comprises a therapeutic module configured to apply thermal treatment to a subject; an ultrasound imaging module; an optoacoustic imaging module; a processing module connected to both ultrasound and optoacoustic based imaging module; and an operating controlling module connected with said processing module and configured to manipulate at least one of said therapeutic module, ultrasound imaging module or optoacoustic imaging module. The calibration method is able to eliminate the inconsistency of optoacoustic based temperature measurements caused by sample-to-sample and spatial variations of Gruneisen parameter for different tissues. The method for temperature-structure imaging is able to generate both two dimensional and three dimensional co-registered structure and temperature images for the tissues inside a region of interest of a subject.
摘要翻译： 本文提供了用于监测和指导人或动物组织内的热疗程序的系统和方法。 该系统包括治疗模块，该治疗模块被配置为对受试者施加热治疗; 超声成像模块; 光声成像模块; 连接到超声波和光声成像模块的处理模块; 以及与所述处理模块连接并被配置为操纵所述治疗模块，超声成像模块或光声成像模块中的至少一个的操作控制模块。 校准方法能够消除由样本与样本之间引起的基于光声的温度测量和不同组织的Gruneisen参数的空间变化的不一致性。 用于温度结构成像的方法能够产生受试者感兴趣区域内的组织的二维和三维共注册结构和温度图像。
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