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公开(公告)号：US07998667B1
公开(公告)日：2011-08-16
申请号：US09856290
申请日：1999-11-18
申请人： Alexis Brice , Christophe Lucking , Patrice Denefle , Sylvain Ricard , Nacer Eddine Abbas , Sandrine Bouley
发明人： Alexis Brice , Christophe Lucking , Patrice Denefle , Sylvain Ricard , Nacer Eddine Abbas , Sandrine Bouley
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16
摘要： The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
摘要翻译： 本发明涉及编码人parkin基因的突变形式或截短形式的核酸或包含外显子增殖的形式，以及相应的蛋白质和抗体。 本发明还涉及用于鉴定parkin基因突变的方法和试剂盒，并用于研究用于治疗目的的化合物。
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公开(公告)号：US08835618B2
公开(公告)日：2014-09-16
申请号：US13209495
申请日：2011-08-15
申请人： Alexis Brice , Christophe Lucking , Patrice Denefle , Sylvain Ricard , Nacer Eddine Abbas , Sandrine Bouley
发明人： Alexis Brice , Christophe Lucking , Patrice Denefle , Sylvain Ricard , Nacer Eddine Abbas , Sandrine Bouley
CPC分类号： C12Q1/6883 , C07K16/40 , C12N9/104 , C12N9/93 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Y603/02019
摘要： The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
摘要翻译： 本发明涉及编码人parkin基因的突变形式或截短形式的核酸或包含外显子增殖的形式，以及相应的蛋白质和抗体。 本发明还涉及用于鉴定parkin基因突变的方法和试剂盒，并用于研究用于治疗目的的化合物。
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公开(公告)号：US20120064598A1
公开(公告)日：2012-03-15
申请号：US13209495
申请日：2011-08-15
申请人： Alexis Brice , Christophe Lucking , Patrice Denefle , Sylvain Ricard , Nacer Eddine Abbas , Sandrine Bouley
发明人： Alexis Brice , Christophe Lucking , Patrice Denefle , Sylvain Ricard , Nacer Eddine Abbas , Sandrine Bouley
IPC分类号： C12N9/00 , C07K16/40 , C07H21/00 , C12N5/10 , C12N5/04 , C12N1/21 , C12N1/19 , C12N15/52 , C12N15/63
CPC分类号： C12Q1/6883 , C07K16/40 , C12N9/104 , C12N9/93 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Y603/02019
摘要： The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
摘要翻译： 本发明涉及编码人parkin基因的突变形式或截短形式的核酸或包含外显子增殖的形式，以及相应的蛋白质和抗体。 本发明还涉及用于鉴定parkin基因突变的方法和试剂盒，并用于研究用于治疗目的的化合物。
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公开(公告)号：US06258596B1
公开(公告)日：2001-07-10
申请号：US08952796
申请日：1998-06-05
申请人： Patrick Benoit , Eric Bruckert , Patrice Denefle , Nicolas Duverger , Jean-Charles Fruchart , Gérald Luc , Gérard Turpin , Gerd Assmann , Harald Funke
发明人： Patrick Benoit , Eric Bruckert , Patrice Denefle , Nicolas Duverger , Jean-Charles Fruchart , Gérald Luc , Gérard Turpin , Gerd Assmann , Harald Funke
IPC分类号： C07K1600
CPC分类号： C07K14/775 , A61K38/00 , A61K48/00 , C12N2799/021 , C12N2799/022
摘要： The present invention relates to variants of the human apolipoproteine A-I comprising a cystein in position 151, the corresponding nucleic acids and the vectors containing them. It also relates to pharmaceutical compositions comprising said elements and their utilization, particularly in genic therapy.
摘要翻译： 本发明涉及包含151位半胱氨酸的人载脂蛋白A-1的变体，相应的核酸和含有它们的载体。 它还涉及包含所述元件及其利用的药物组合物，特别是在基因治疗中。
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5.发明授权Recombinant adero viruses comprising an inserted gene encoding apolipoprotein and their use in gene therapy for dyslipoproteinemias 失效包含编码载脂蛋白的插入基因及其在脂蛋白血症基因治疗中的应用的重组腺病毒
公开(公告)号：US5866551A
公开(公告)日：1999-02-02
申请号：US535243
申请日：1996-01-11
IPC分类号： C12N15/09 , A01N43/04 , A01N63/00 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/10 , A61P25/00 , C07K14/775 , C12N7/01 , C12N15/00 , C12N15/861 , C12N15/63 , C12N5/00
CPC分类号： C12N15/86 , C07K14/775 , A61K38/00 , C12N2710/10343
摘要： The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the treatment or prevention of pathologies linked to dyslipoproteinemias.
摘要翻译： PCT No.PCT / FR94 / 00422 Sec。 371日期1996年1月11日 102（e）日期1996年1月11日PCT 1994年4月15日PCT PCT。 第WO94 / 25073号公报 日期1994年11月10日本发明涉及含有编码载脂蛋白的插入基因，包含腺病毒的药物组合物及其用于治疗或预防与脂蛋白血症相关的病理学的用途的有缺陷的重组腺病毒。
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公开(公告)号：US08623831B2
公开(公告)日：2014-01-07
申请号：US13157798
申请日：2011-06-10
申请人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
发明人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
CPC分类号： C07K14/4705 , A61K38/00 , A61K48/00
摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
摘要翻译： 本发明涉及能诱导NFκB的核因子κB（NFκB）诱导因子多肽（NF-κB）诱导因子多肽（NFIF多肽）。 本发明在其范围内包括NFIF多肽，包括NFIF-14b和NFIF-7a，包括编码这些多肽的cDNA，以及能够表达NFIF多肽的表达载体。 还包括用于增加患者中NFkappaB诱导的方法和组合物，用于降低患者中NFkappaB诱导的方法和组合物，用于抑制炎症的方法和用于制备用于治疗和/或预防NFκB调节的药物的方法 炎症反应。 此外，提供了用于确定测试化合物是否抑制或增强NFIF多肽的活性的方法。
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7.发明授权Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses 有权ABC1基因的调控核酸，修饰其活性和治疗用途的分子公开(公告)号：US07378274B2
公开(公告)日：2008-05-27
申请号：US09846456
申请日：2001-05-02
申请人： Marie-Françoise Rosier-Montus , Catherine Prades , Cendrine Lemoine , Laurent Naudin , Patrice Denefle , Nicolas Duverger , Bryan Brewer , Alan Remaley , Sylvia Santamarina-Fojo
发明人： Marie-Françoise Rosier-Montus , Catherine Prades , Cendrine Lemoine , Laurent Naudin , Patrice Denefle , Nicolas Duverger , Bryan Brewer , Alan Remaley , Sylvia Santamarina-Fojo
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , G01N2500/10
摘要： The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. The invention also relates to recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene.
摘要翻译： 本发明涉及一种能够调节ABC1基因转录的核酸，该ABC1基因是与胆固醇代谢功能异常有关的病理学的致病基因，诱导诸如动脉粥样硬化的疾病。 本发明还涉及包含编码感兴趣的多肽或核酸的多核苷酸的核苷酸构建体，其在控制下置于ABC1基因的调控核酸上。 本发明还涉及重组载体，转化宿主细胞和非人类转基因哺乳动物，其包含调节ABC1基因或上述核苷酸构建体的转录的核酸，以及用于筛选能够改变活性的分子或物质的方法 ABC1基因的调控核酸。
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8.发明授权
公开(公告)号：US5851521A
公开(公告)日：1998-12-22
申请号：US723726
申请日：1996-09-30
IPC分类号： C12N15/09 , A61K9/10 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/00 , A61P43/00 , C07K14/47 , C12N7/00 , C12N7/01 , C12N15/63 , C12N15/86
CPC分类号： C07K14/4703 , A61K38/00 , A61K48/00 , C12N2799/022
摘要： The present invention relates to replication defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angioplastic restenosis.
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9.发明申请公开(公告)号：US20050158784A1
公开(公告)日：2005-07-21
申请号：US11034277
申请日：2005-01-12
申请人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
发明人： Marie Rosier , Catherine Prades , Isabelle Arnould , Michael Dean , Rando Allikmets , Patrice Denefle
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P25/14 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C12Q1/6883 , G01N33/68 , C07H21/04
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/705 , C07K16/28 , C12N2799/021 , C12Q2600/156 , C12Q2600/158 , G01N33/68
摘要： The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCC11 gene or in the corresponding protein produced by the allelic form of the ABCC11 gene.
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10.再颁专利Recombinant adeno viruses comprising an inserted gene encoding apolipoprotein and their use in gene therapy for dyslipoproteinemias 有权包含编码载脂蛋白的插入基因及其在脂蛋白血症基因治疗中的应用的重组腺病毒公开(公告)号：USRE38556E1
公开(公告)日：2004-07-13
申请号：US09636771
申请日：2000-08-04
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K38/00 , C07K14/775 , C12N2710/10343
摘要： The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the treatment or prevention of pathologies linked to dyslipoproteinemias.
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