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公开(公告)号：US20120082983A1
公开(公告)日：2012-04-05
申请号：US13294927
申请日：2011-11-11
申请人： Alfred M. Spormann , Jochen A. Muller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L. McCarty
发明人： Alfred M. Spormann , Jochen A. Muller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L. McCarty
CPC分类号： C12N1/30 , B09C1/002 , C12N9/0004
摘要： Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.
摘要翻译： 提供了组合物和方法，其涉及氯化乙烯的生物修复，特别是由脱卤胆酸类生物体对氯乙烯的生物修复。 一种分离的细菌菌株，Dehalococcoides sp。 提供代谢氯乙烯的菌株VS; 负责氯乙烯脱卤的酶的基因序列; 评估环境部位内源生物体代谢氯乙烯能力的方法; 以及使用本发明的菌株进行生物修复的方法。
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公开(公告)号：US08063192B2
公开(公告)日：2011-11-22
申请号：US11659064
申请日：2005-08-02
申请人： Alfred M. Spormann , Jochen A. Müller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L McCarty
发明人： Alfred M. Spormann , Jochen A. Müller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L McCarty
IPC分类号： C07H21/04
CPC分类号： C12N1/30 , B09C1/002 , C12N9/0004
摘要： Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.
摘要翻译： 提供了组合物和方法，其涉及氯化乙烯的生物修复，特别是由脱卤胆酸类生物体对氯乙烯的生物修复。 一种分离的细菌菌株，Dehalococcoides sp。 提供代谢氯乙烯的菌株VS; 负责氯乙烯脱卤的酶的基因序列; 评估环境部位内源生物体代谢氯乙烯能力的方法; 以及使用本发明的菌株进行生物修复的方法。
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公开(公告)号：US20090176210A1
公开(公告)日：2009-07-09
申请号：US11659064
申请日：2005-08-02
申请人： Alfred M. Spormann , Jochen A. Müller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L McCarty
发明人： Alfred M. Spormann , Jochen A. Müller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L McCarty
CPC分类号： C12N1/30 , B09C1/002 , C12N9/0004
摘要： Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.
摘要翻译： 提供了组合物和方法，其涉及氯化乙烯的生物修复，特别是由脱卤胆酸类生物体对氯乙烯的生物修复。 一种分离的细菌菌株，Dehalococcoides sp。 提供代谢氯乙烯的菌株VS; 负责氯乙烯脱卤的酶的基因序列; 评估环境部位内源生物体代谢氯乙烯能力的方法; 以及使用本发明的菌株进行生物修复的方法。
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公开(公告)号：US08647824B2
公开(公告)日：2014-02-11
申请号：US13294927
申请日：2011-11-11
申请人： Alfred M. Spormann , Jochen A. Müller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L. McCarty
发明人： Alfred M. Spormann , Jochen A. Müller , Bettina M. Rosner , Gregory Von Abendroth , Galit Meshulam-Simon , Perry L. McCarty
IPC分类号： C12Q1/68
CPC分类号： C12N1/30 , B09C1/002 , C12N9/0004
摘要： Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.
摘要翻译： 提供了组合物和方法，其涉及氯化乙烯的生物修复，特别是由脱卤胆酸类生物体对氯乙烯的生物修复。 一种分离的细菌菌株，Dehalococcoides sp。 提供代谢氯乙烯的菌株VS; 负责氯乙烯脱卤的酶的基因序列; 评估环境部位内源生物体代谢氯乙烯能力的方法; 以及使用本发明的菌株进行生物修复的方法。
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公开(公告)号：US07794994B2
公开(公告)日：2010-09-14
申请号：US10494923
申请日：2002-11-08
申请人： Paul E. Cranley , Jeffrey R. Allen , Kristine L. Danowski , James A. McIntyre , Theodore E. Miller, Jr. , Bettina M. Rosner , Alan D. Strickland , Venkiteswaran Subramanian , Larry Sun
发明人： Paul E. Cranley , Jeffrey R. Allen , Kristine L. Danowski , James A. McIntyre , Theodore E. Miller, Jr. , Bettina M. Rosner , Alan D. Strickland , Venkiteswaran Subramanian , Larry Sun
CPC分类号： C12N9/0006 , C12P7/04 , C12P7/28 , C12Q1/005
摘要： Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics.
摘要翻译： 描述了丙酮特有的酶系统和使用这些酶系统检测生物或环境样品中的丙酮的方法。 公开了含有这些酶系统的生物传感器，其中可以通过将电化学，光度或其它检测手段与一种或多种丙酮特异性酶反应或途径连接来实现丙酮的检测。 使用这种丙酮特异性生物传感器的方法包括体重减轻，疾病检测和治疗剂的生物利用度监测的受试者管理。
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6.发明授权公开(公告)号：US07382263B2
公开(公告)日：2008-06-03
申请号：US11436917
申请日：2006-05-18
申请人： Kristine L. Danowski , Larry S. Sun , Peter K. Mercure , Robert P. Haley , Douglas P. White , Michelle A. Pressler , Susan J. Babinec , Flor A. Castillo , Jahne Simon , Paul E. Cranley , Malcolm W. Warren, II , Diedre A. Strand , Bettina M. Rosner , Robert B. Fletcher , Christopher M. Jones , Thomas H. Kalantar , Mark T. Bernius , W. Chris McDougall , Mark S. B. Felix
发明人： Kristine L. Danowski , Larry S. Sun , Peter K. Mercure , Robert P. Haley , Douglas P. White , Michelle A. Pressler , Susan J. Babinec , Flor A. Castillo , Jahne Simon , Paul E. Cranley , Malcolm W. Warren, II , Diedre A. Strand , Bettina M. Rosner , Robert B. Fletcher , Christopher M. Jones , Thomas H. Kalantar , Mark T. Bernius , W. Chris McDougall , Mark S. B. Felix
CPC分类号： G06K19/04 , A01K11/007 , A61B5/4833 , A61J3/007 , A61J3/071 , A61J2200/30 , A61K9/0009 , A61K9/2072 , A61K9/4808 , G06K7/0008 , G06K7/10079 , G06K19/07327 , G06K19/07336 , G06K19/07345 , G06K19/07749 , H01Q1/2208 , H01Q1/273 , H01Q1/362 , H01Q7/00 , H01Q11/08
摘要： A device useful for oral drug delivery device consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) an RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an antenna; (c) an object selected from the group consisting of a magnet, a ferromagnetic object, a ferrite object and an electromagnetic shielding object positioned within, over or adjacent the antenna of the RFID tag to alter the antenna characteristics of the RFID tag so that if the RFID tag is interrogated before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tag is sufficiently altered or attenuated to determine that the capsule, tablet or pill has not dispersed in the gastrointestinal system and so that if the RFID tag is interrogated after the capsule, tablet or pill has dispersed in the gastrointestinal system, the object separates from the RFID tag so that the response of the RFID tag is sufficiently detectable to determine that the capsule, tablet or pill has dispersed in the gastrointestinal system. Alternatively, a switch can be used to signal ingestion of the device, and change the response of the device.
摘要翻译： 用于口服药物递送装置的装置包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）定位在胶囊，药片或药丸中的RFID标签，RFID标签包括天线; （c）选自位于RFID标签的天线之内或之上的磁体，铁磁体，铁氧体物体和电磁屏蔽物体的物体，以改变RFID标签的天线特性，使得如果 在胶囊，片剂或药丸分散在胃肠系统中之前询问RFID标签，RFID标签的反应被充分改变或减弱，以确定胶囊，片剂或药片未分散在胃肠系统中，并且如果 在胶囊，片剂或药丸已经分散在胃肠系统中之后，RFID标签被询问，物体与RFID标签分离，使得RFID标签的反应充分可检测，以确定胶囊，片剂或药片已经分散在胃肠道 系统。 或者，可以使用开关来信号摄取设备，并且改变设备的响应。
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公开(公告)号：US20100135907A1
公开(公告)日：2010-06-03
申请号：US11989225
申请日：2006-07-21
申请人： Paul E. Cranley , Larry S. Sun , Malcolm W. Warren , Michelle A. Pressler , Kristine L. Danowski , Hamed Lakrout , Christopher M. Jones , Doug P. White , Flor A. Castillo , Bettina M. Rosner
发明人： Paul E. Cranley , Larry S. Sun , Malcolm W. Warren , Michelle A. Pressler , Kristine L. Danowski , Hamed Lakrout , Christopher M. Jones , Doug P. White , Flor A. Castillo , Bettina M. Rosner
CPC分类号： A61B7/008 , A61B5/42 , A61B5/4839 , A61B5/6831 , A61B5/7405 , A61B8/12 , A61K9/0009
摘要： A tablet, pill or capsule containing a material which produces sound waves when the tablet, pill or capsule is exposed to the gastrointestinal system. A two step method for oral drug compliance monitoring. The first step is to ingest a tablet, pill or capsule containing a material which produces sound waves when the tablet, pill or capsule is exposed to the gastrointestinal system of a person. The second step is to detect the sound waves produced when the tablet, pill or capsule is exposed to the gastrointestinal system to confirm that the person has ingested the tablet, pill or capsule.
摘要翻译： 包含片剂，药丸或胶囊暴露于胃肠系统时产生声波的材料的片剂，丸剂或胶囊。 口服药物依从性监测的两步法。 第一步是摄取含有当片剂，药丸或胶囊暴露于人的胃肠系统时产生声波的材料的片剂，药丸或胶囊。 第二步是检测当片剂，药丸或胶囊暴露于胃肠系统时产生的声波，以确认该人已经摄取了片剂，丸剂或胶囊。
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公开(公告)号：US07364551B2
公开(公告)日：2008-04-29
申请号：US10492953
申请日：2002-11-08
申请人： Jeffrey R. Allen , Paul E. Cranley , Kristine L. Danowski , James A. McIntyre , Reed A. Schick , Larry Sun , Bettina M. Rosner
发明人： Jeffrey R. Allen , Paul E. Cranley , Kristine L. Danowski , James A. McIntyre , Reed A. Schick , Larry Sun , Bettina M. Rosner
IPC分类号： A61B5/08
CPC分类号： A61B5/411 , A61B5/0002 , A61B5/083 , A61B10/00 , A61B2010/0009 , C12P7/04 , C12P7/28
摘要： The subject invention provides a hand-held medical apparatus (10) for detecting a predetermined component of user breath and producing a breath-component signal over a measurement time. Such breath-component signal may be correlated to a user fat metabolism indicator.
摘要翻译： 本发明提供一种用于检测用户呼吸的预定成分并在测量时间产生呼吸分量信号的手持式医疗装置（10）。 这样的呼吸分量信号可以与用户脂肪代谢指示符相关。
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