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1.发明授权Cartridge for storing biosample plates and use in automated data storage systems 失效用于存储生物样品板的墨盒，用于自动化数据存储系统公开(公告)号：US08640964B2
公开(公告)日：2014-02-04
申请号：US13151249
申请日：2011-06-01
申请人： Allen Keith Bates , Nils Haustein , James William Johnson , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
发明人： Allen Keith Bates , Nils Haustein , James William Johnson , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
IPC分类号： G06K19/06
CPC分类号： G01N33/48778 , G11B23/023 , G11B23/042 , G11B23/049
摘要： Embodiments of the disclosure relate to a biosample cartridge that includes storage slots for holding biosample plates. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a biosample storage cartridge that has a movable door to provide access to inside the cartridge and a plate holder disposed inside the cartridge. The plate holder includes a plurality of slots for receiving biosample plates that are scanned and processed by the automated tape library.
摘要翻译： 本公开的实施例涉及一种生物样本盒，其包括用于保持生物样本板的存储槽。 墨盒具有与数据磁带盒相同的外形尺寸，以使墨盒能够通过处理自动磁带库中数据墨盒的相同机器人机构来处理。 本公开的一个方面涉及一种生物样本存储盒，其具有可移动门以提供对盒内部的访问以及设置在盒内的板保持架。 板保持器包括用于接收由自动化磁带库扫描和处理的生物样本板的多个槽。
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2.发明授权公开(公告)号：US09229071B2
公开(公告)日：2016-01-05
申请号：US13151258
申请日：2011-06-01
CPC分类号： G01R33/091 , G01N27/72 , G01R33/093 , G01R33/1269
摘要： The invention relates to the identification of molecules using electromagnetic write-heads and magneto-resistive sensors. In one embodiment, an electromagnetic write-head magnetically excites a molecule with an alternating magnetic field. A magneto-resistive sensor measures the resonant response of the magnetically excited molecule. A processor compares the resonant response to a table of known responses of different molecules to identify the chemical composition of the target molecule.
摘要翻译： 本发明涉及使用电磁写入头和磁阻传感器识别分子。 在一个实施例中，电磁写头磁性激发具有交变磁场的分子。 磁阻传感器测量磁激发分子的共振响应。 处理器将共振响应与不同分子的已知响应表进行比较，以鉴定目标分子的化学组成。
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3.发明授权Cartridge for storing biosample capillary tubes and use in automated data storage systems 有权用于存储生物样品毛细管的墨盒，用于自动数据存储系统公开(公告)号：US09286914B2
公开(公告)日：2016-03-15
申请号：US13151247
申请日：2011-06-01
申请人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
发明人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
CPC分类号： B01L9/065 , A61B5/150305 , A61B10/0096 , B01L2300/0809 , B01L2300/0812 , G01N35/00029 , G01N35/00732 , G01N35/0099 , G01N2035/00762 , G01N2035/00801 , G01N2035/0425 , G11B5/00821 , G11B23/049 , H04B7/24
摘要： Embodiments of the disclosure relate to a cartridge that includes slots for storing biosample capillary tubes. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a cartridge comprising an enclosure that includes a movable door to provide access to a tube holder in the enclosure. The tube holder includes cylindrical holes or slots for receiving capillary tubes which contain biosamples scanned and analyzed an automated tape library.
摘要翻译： 本公开的实施例涉及一种盒，其包括用于存储生物样品毛细管的槽。 墨盒具有与数据磁带盒相同的外形尺寸，以使墨盒能够通过处理自动磁带库中数据墨盒的相同机器人机构来处理。 本公开的一个方面涉及一种盒，其包括包括可移动门的外壳，以提供对外壳中的管座的接近。 管支架包括用于接收毛细管的圆柱形孔或槽，其包含扫描并分析了自动化磁带库的生物样本。
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4.发明申请IDENTIFICATION OF MOLECULES BASED ON FREQUENCY RESPONSES USING ELECTROMAGNETIC WRITE-HEADS AND MAGNETO-RESISTIVE SENSORS 有权基于使用电磁写头和磁电阻传感器的频率响应的分子鉴定公开(公告)号：US20120310550A1
公开(公告)日：2012-12-06
申请号：US13151258
申请日：2011-06-01
IPC分类号： G06F19/00
CPC分类号： G01R33/091 , G01N27/72 , G01R33/093 , G01R33/1269
摘要： The invention relates to the identification of molecules using electromagnetic write-heads and magneto-resistive sensors. In one embodiment, an electromagnetic write-head magnetically excites a molecule with an alternating magnetic field. A magneto-resistive sensor measures the resonant response of the magnetically excited molecule. A processor compares the resonant response to a table of known responses of different molecules to identify the chemical composition of the target molecule.
摘要翻译： 本发明涉及使用电磁写入头和磁阻传感器识别分子。 在一个实施例中，电磁写头磁性激发具有交变磁场的分子。 磁阻传感器测量磁激发分子的共振响应。 处理器将共振响应与不同分子的已知响应表进行比较，以鉴定目标分子的化学组成。
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5.发明申请CARTRIDGE FOR STORING BIOSAMPLE CAPILLARY TUBES AND USE IN AUTOMATED DATA STORAGE SYSTEMS 有权用于存储生物柴油毛细管的盒子和用于自动数据存储系统公开(公告)号：US20120309297A1
公开(公告)日：2012-12-06
申请号：US13151247
申请日：2011-06-01
申请人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
发明人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
CPC分类号： B01L9/065 , A61B5/150305 , A61B10/0096 , B01L2300/0809 , B01L2300/0812 , G01N35/00029 , G01N35/00732 , G01N35/0099 , G01N2035/00762 , G01N2035/00801 , G01N2035/0425 , G11B5/00821 , G11B23/049 , H04B7/24
摘要： Embodiments of the disclosure relate to a cartridge that includes slots for storing biosample capillary tubes. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a cartridge comprising an enclosure that includes a movable door to provide access to a tube holder in the enclosure. The tube holder includes cylindrical holes or slots for receiving capillary tubes which contain biosamples scanned and analyzed an automated tape library.
摘要翻译： 本公开的实施例涉及一种盒，其包括用于存储生物样品毛细管的槽。 墨盒具有与数据磁带盒相同的外形尺寸，以使墨盒能够通过处理自动磁带库中数据墨盒的相同机器人机构来处理。 本公开的一个方面涉及一种盒，其包括包括可移动门的外壳，以提供对外壳中的管座的接近。 管支架包括用于接收毛细管的圆柱形孔或槽，其包含扫描并分析了自动化磁带库的生物样本。
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6.发明申请CARTRIDGE FOR STORING BIOSAMPLE PLATES AND USE IN AUTOMATED DATA STORAGE SYSTEMS 失效用于存储生物活化板和用于自动数据存储系统的盒子公开(公告)号：US20120309298A1
公开(公告)日：2012-12-06
申请号：US13151249
申请日：2011-06-01
申请人： Allen Keith Bates , Nils Haustein , James William Johnson , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
发明人： Allen Keith Bates , Nils Haustein , James William Johnson , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
CPC分类号： G01N33/48778 , G11B23/023 , G11B23/042 , G11B23/049
摘要： Embodiments of the disclosure relate to a biosample cartridge that includes storage slots for holding biosample plates. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a biosample storage cartridge that has a movable door to provide access to inside the cartridge and a plate holder disposed inside the cartridge. The plate holder includes a plurality of slots for receiving biosample plates that are scanned and processed by the automated tape library.
摘要翻译： 本公开的实施例涉及一种生物样本盒，其包括用于保持生物样本板的存储槽。 墨盒具有与数据磁带盒相同的外形尺寸，以使墨盒能够通过处理自动磁带库中数据墨盒的相同机器人机构来处理。 本公开的一个方面涉及一种生物样本存储盒，其具有可移动门以提供对盒内部的访问以及设置在盒内的板保持架。 板保持器包括用于接收由自动化磁带库扫描和处理的生物样本板的多个槽。
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公开(公告)号：US08855957B2
公开(公告)日：2014-10-07
申请号：US13099360
申请日：2011-05-03
申请人： David Berman , Dylan Joseph Boday , Icko E. T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
发明人： David Berman , Dylan Joseph Boday , Icko E. T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
CPC分类号： G01R35/00 , G01N27/04 , G01N27/72 , G01N33/53 , G01R33/0035 , G01R33/1207
摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. If it is determined that a read sensor is degraded a method of calibrating a read sensor of a read head is described. In one embodiment, a method of calibrating a magnetic read sensor includes measuring a first resistance of the magnetic read sensor upon an application of a forward bias current to the magnetic read sensor and measuring a second resistance of the magnetic read sensor upon an application of a reverse bias current to the magnetic read sensor. A calibration constant is determined based on at least the first measured resistance and the second measured resistance. In one embodiment the method further includes storing the determined calibration constant for the magnetic read sensor in memory. Further, in one embodiment the head module having the magnetic read sensor is swept over at least one nanoparticle to obtain a read response of the magnetic read sensor to the nanoparticle. The read response from the magnetic read sensor of the at least one nanoparticle is adjusted based on the determined calibration constant. Calibration of each individual read sensor allows for uniform read responses from each of the read sensors on a read head, and prevents unreliable an inaccurate detection of analytes due to sensor degradation.
摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 如果确定读取传感器劣化，则描述校准读取头的读取传感器的方法。 在一个实施例中，一种校准磁性读取传感器的方法包括：在向磁性读取传感器施加正向偏置电流时测量磁性读取传感器的第一个电阻，并测量磁性读取传感器的应用时的第二个电阻 反向偏置电流到磁性读取传感器。 基于至少第一测量电阻和第二测量电阻来确定校准常数。 在一个实施例中，该方法还包括将所确定的磁读取传感器的校准常数存储在存储器中。 此外，在一个实施例中，具有磁读取传感器的头模块扫过至少一个纳米颗粒，以获得磁读取传感器对纳米颗粒的读取响应。 基于所确定的校准常数来调整来自至少一个纳米颗粒的磁读取传感器的读取响应。 每个单独的读取传感器的校准允许来自读取头上的每个读取传感器的均匀的读取响应，并且防止由于传感器劣化而导致的分析物不可靠的检测不可靠。
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8.发明授权公开(公告)号：US09417237B2
公开(公告)日：2016-08-16
申请号：US13151265
申请日：2011-06-01
IPC分类号： B01L3/00 , G01N33/553 , G01N35/00 , G01N33/487 , G06F3/06
CPC分类号： G01N35/00732 , B01L3/50 , B01L3/508 , B01L3/5085 , B01L3/545 , B01L2200/025 , B01L2200/10 , B01L2300/021 , B01L2300/023 , B01L2300/024 , B01L2300/0809 , G01N33/48792 , G01N33/553 , G01N35/00029 , G01N35/00871 , G01N2035/00019 , G01N2035/00089 , G01N2035/00099 , G01N2035/00841 , G06F3/061 , G06F3/0661 , G06F3/0676
摘要： Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing information related to the biosample, biosample plate and biosample analysis data, and a wireless communication interface for transferring information to and from the biosample plate. The biosample plate may be used with an analyzing and data recording system such as an electromagnetic tape drive. The disclosed biosample plate facilitates the correlation between a large number of biosample plates and data as data remains with the corresponding biosamples both when the biosample plates are in use and when they are in storage. The wireless communication interface may comprise an antenna disposed in a biosample plate for data transmission to and from the biosample plate by radio signals.
摘要翻译： 本公开的实施例涉及一种生物样本板，其包括用于存储与生物样本，生物样本板和生物样本分析数据相关的信息的存储器组件，以及用于向生物样本板传送信息的无线通信接口。 生物样本板可以与诸如电磁带驱动器的分析和数据记录系统一起使用。 所公开的生物样品板有利于大量生物样本板和数据之间的相关性，因为当生物样本板正在使用时以及当它们处于储存状态时，数据保留在相应的生物样本上。 无线通信接口可以包括设置在生物样本板中的天线，用于通过无线电信号传送到和从生物样本板的数据传输。
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9.发明申请公开(公告)号：US20120283976A1
公开(公告)日：2012-11-08
申请号：US13099360
申请日：2011-05-03
申请人： David Berman , Dylan Joseph Boday , Icko E.T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
发明人： David Berman , Dylan Joseph Boday , Icko E.T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
IPC分类号： G06F19/00
CPC分类号： G01R35/00 , G01N27/04 , G01N27/72 , G01N33/53 , G01R33/0035 , G01R33/1207
摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. If it is determined that a read sensor is degraded a method of calibrating a read sensor of a read head is described. In one embodiment, a method of calibrating a magnetic read sensor includes measuring a first resistance of the magnetic read sensor upon an application of a forward bias current to the magnetic read sensor and measuring a second resistance of the magnetic read sensor upon an application of a reverse bias current to the magnetic read sensor. A calibration constant is determined based on at least the first measured resistance and the second measured resistance. In one embodiment the method further includes storing the determined calibration constant for the magnetic read sensor in memory. Further, in one embodiment the head module having the magnetic read sensor is swept over at least one nanoparticle to obtain a read response of the magnetic read sensor to the nanoparticle. The read response from the magnetic read sensor of the at least one nanoparticle is adjusted based on the determined calibration constant. Calibration of each individual read sensor allows for uniform read responses from each of the read sensors on a read head, and prevents unreliable an inaccurate detection of analytes due to sensor degradation.
摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 如果确定读取传感器劣化，则描述校准读取头的读取传感器的方法。 在一个实施例中，一种校准磁性读取传感器的方法包括：在向磁性读取传感器施加正向偏置电流时测量磁性读取传感器的第一个电阻，并测量磁性读取传感器的应用时的第二个电阻 反向偏置电流到磁性读取传感器。 基于至少第一测量电阻和第二测量电阻来确定校准常数。 在一个实施例中，该方法还包括将所确定的磁读取传感器的校准常数存储在存储器中。 此外，在一个实施例中，具有磁读取传感器的头模块扫过至少一个纳米颗粒，以获得磁读取传感器对纳米颗粒的读取响应。 基于所确定的校准常数来调整来自至少一个纳米颗粒的磁读取传感器的读取响应。 每个单独的读取传感器的校准允许来自读取头上的每个读取传感器的均匀的读取响应，并且防止由于传感器劣化而导致的分析物不可靠的检测不可靠。
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10.发明授权公开(公告)号：US09040311B2
公开(公告)日：2015-05-26
申请号：US13099358
申请日：2011-05-03
申请人： David Berman , Dylan Joseph Boday , Icko E.T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
发明人： David Berman , Dylan Joseph Boday , Icko E.T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
CPC分类号： G01R33/0035 , G01N27/72 , G01N27/745 , G01R33/09 , G01R33/1269 , G01R35/00 , G01R35/005
摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. Accordingly, one embodiment of the invention includes a calibration assembly having nanoparticles, with known magnetic properties, spaced apart at known y-axis locations along the calibration assembly. In one embodiment, the calibration assembly may be used to calibrate a matched filter of the write and read circuitry. Because the calibration assembly comprises nanoparticles with known magnetic properties the read response of the read circuitry to a particular nanoparticle may be stored in the matched filter as an ideal signal for that nanoparticle. The ideal signal stored in the matched filter may then be utilized for reliably and accurately detecting antigens. Still further, the ideal signal stored within the matched filter of the write and read circuitry may be utilized in a correlation test of a calibration assembly to ensure that the calibration assembly is within a manufacturer's or user's acceptable standards for calibration of their write and read assemblies.
摘要翻译： 描述了确保用于检测抗原的设备是可靠和准确的实施方案。 因此，本发明的一个实施例包括具有已知磁性的纳米颗粒的校准组件，沿着校准组件在已知的y轴位置间隔开。 在一个实施例中，校准组件可用于校准写入和读取电路的匹配滤波器。 因为校准组件包括具有已知磁性的纳米颗粒，读取电路对特定纳米颗粒的读取响应可以作为该纳米颗粒的理想信号存储在匹配滤波器中。 然后可以将存储在匹配滤波器中的理想信号用于可靠且准确地检测抗原。 此外，存储在写入和读取电路的匹配滤波器内的理想信号可以用于校准组件的相关测试中，以确保校准组件在制造商或用户可接受的标准内用于校准其写入和读取组件 。
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