Biological and chemical microcavity resonant sensors and methods of detecting molecules
    1.
    发明授权
    Biological and chemical microcavity resonant sensors and methods of detecting molecules 有权
    生物和化学微腔谐振传感器和分子检测方法

    公开(公告)号:US07781217B2

    公开(公告)日:2010-08-24

    申请号:US11733480

    申请日:2007-04-10

    IPC分类号: G01N23/00

    摘要: Resonant sensors and methods of detecting specific molecules with enhanced sensitivity. Optical energy is introduced into a microcavity, such as a silica toroid-shaped microcavity. The microcavity sensor has a functionalized outer surface and a sufficiently high Q value to generate an evanescent optical field with increased intensity. A molecule bound to the functionalized outer surface interacts with the external optical field, thereby heating the microcavity and generating a detectable resonant wavelength shift, which indicates a small number of molecules, even a single molecule, without the use of fluorescent or metal labels. Resonant sensors and methods can also be used to detect specific molecules, even a single molecule, within an environment. One application is detecting very small quantities or a single molecule of heavy water in ordinary water.

    摘要翻译: 共振传感器和检测具有增强灵敏度的特定分子的方法。 将光能引入到微腔中,例如二氧化硅环形微腔。 微腔传感器具有功能化的外表面和足够高的Q值以产生具有增加的强度的渐逝光场。 结合到官能化外表面的分子与外部光场相互作用,从而加热微腔并产生可检测的共振波长漂移,其表示少量分子,甚至单个分子,而不使用荧光或金属标记。 谐振传感器和方法也可用于检测环境中的特定分子,甚至单个分子。 一种应用是在普通水中检测非常少的量或单一分子的重水。

    SPLIT FREQUENCY SENSING METHODS AND SYSTEMS
    2.
    发明申请
    SPLIT FREQUENCY SENSING METHODS AND SYSTEMS 有权
    分离频率感测方法和系统

    公开(公告)号:US20100085573A1

    公开(公告)日:2010-04-08

    申请号:US12573009

    申请日:2009-10-02

    IPC分类号: G01B9/02

    CPC分类号: G01N21/7746

    摘要: Resonant sensors and molecule detection methods utilizing split frequency. Optical energy is introduced into a microcavity, such as a toroid-shaped or spherical microcavity. A portion of the optical energy is backscattered and interacts with the introduced optical energy to form first and second modes of optical energy at respective first and second frequencies, also referred to as split frequency or mode doublets. One or more molecules bind to an outer surface of the microcavity and interact with an evanescent field of optical energy resonating within the microcavity. Binding of one or more molecules to the outer surface is detected based at least in part upon a change of the split frequency relative to a baseline split frequency.

    摘要翻译: 谐振传感器和分子检测方法利用分频。 将光能引入微腔中,例如环形或球形微腔。 光能的一部分被反向散射并与引入的光能相互作用以在相应的第一和第二频率处形成第一和第二光能模式,也被称为分裂频率或模式双峰。 一个或多个分子结合到微腔的外表面并与在微腔内共振的光能的消逝场相互作用。 至少部分地基于分割频率相对于基线分割频率的变化来检测一个或多个分子与外表面的结合。

    Split frequency sensing methods and systems
    3.
    发明授权
    Split frequency sensing methods and systems 有权
    分频检测方法和系统

    公开(公告)号:US08593638B2

    公开(公告)日:2013-11-26

    申请号:US12573009

    申请日:2009-10-02

    IPC分类号: G01B9/02

    CPC分类号: G01N21/7746

    摘要: Resonant sensors and molecule detection methods utilizing split frequency. Optical energy is introduced into a microcavity, such as a toroid-shaped or spherical microcavity. A portion of the optical energy is backscattered and interacts with the introduced optical energy to form first and second modes of optical energy at respective first and second frequencies, also referred to as split frequency or mode doublets. One or more molecules bind to an outer surface of the microcavity and interact with an evanescent field of optical energy resonating within the microcavity. Binding of one or more molecules to the outer surface is detected based at least in part upon a change of the split frequency relative to a baseline split frequency.

    摘要翻译: 谐振传感器和分子检测方法利用分频。 将光能引入微腔中,例如环形或球形微腔。 光能的一部分被反向散射并与引入的光能相互作用以在相应的第一和第二频率处形成第一和第二光能模式,也被称为分裂频率或模式双峰。 一个或多个分子结合到微腔的外表面并与在微腔内共振的光能的消逝场相互作用。 至少部分地基于分割频率相对于基线分割频率的变化来检测一个或多个分子与外表面的结合。

    Fiber-coupled microsphere Raman laser

    公开(公告)号:US07003002B2

    公开(公告)日:2006-02-21

    申请号:US10967515

    申请日:2004-10-18

    IPC分类号: H01S3/30 H01S3/08

    摘要: The present invention is a Raman laser and methods related thereto. In the preferred embodiments, the Raman laser comprises a laser pump signal in a fiber waveguide which is optically coupled to a micro-resonator through a fiber taper. The micro-resonator is constructed from a material that has a high Q when it is formed into a micro-resonator and is phase matched to the waveguide. The lasing frequency can be determined based upon the pump input or the micro-resonator material. In the preferred embodiments, the micro-resonator is constructed from a fused silica material. The present invention provides a compact laser with improved emissions and coupling efficiencies and the ability to use stimulated Raman scattering effects to create lasers having frequencies that are otherwise difficult to obtain. Alternative configurations include multiple micro-resonators on a single fiber waveguide and/or utilizing multiple waveguides attached to one or more micro-resonators. The Raman laser can be made to operate in a continuous-wave as opposed to self-pulsing mode.

    Semiconductor laser with photon gain lever
    9.
    发明授权
    Semiconductor laser with photon gain lever 失效
    具有光子增益杆的半导体激光器

    公开(公告)号:US5056100A

    公开(公告)日:1991-10-08

    申请号:US513099

    申请日:1990-04-19

    摘要: A controllable semiconductor laser system including a plurality of semiconductor regions operated at unequal saturation photon densities to permit optical and/or electrical control of lasing in at least one resonant cavity formed therebetween. A pair of such regions may operate as a controllable laser at greater than 100% differential quantum efficiency.

    摘要翻译: 一种可控半导体激光系统,包括在不均匀饱和光子密度下操作的多个半导体区域,以允许在其间形成的至少一个谐振腔中进行激光和/或电控制。 一对这样的区域可以以大于100%的差分量子效率作为可控激光器操作。