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45 条记录 (耗时 0.05 秒)

    Vanilloid receptor ligands and their use in treatments
    2.
    发明授权
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US07265138B2

    公开(公告)日：2007-09-04

    申请号：US10775980

    申请日：2004-02-09

    申请人： Elizabeth M. Doherty ,  Christopher H. Fotsch ,  Nianhe Han ,  Randall W. Hungate ,  Qingyian Liu ,  Mark H. Norman ,  Ning Xi ,  Shimin Xu

    发明人： Elizabeth M. Doherty ,  Christopher H. Fotsch ,  Nianhe Han ,  Randall W. Hungate ,  Qingyian Liu ,  Mark H. Norman ,  Ning Xi ,  Shimin Xu

    IPC分类号： A61K31/425 ,  C07D277/04

    CPC分类号： C07D233/90 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛， 咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    Tyrosine kinase inhibitors
    5.
    发明授权
    Tyrosine kinase inhibitors 失效
    酪氨酸激酶抑制剂

    公开(公告)号：US06544988B1

    公开(公告)日：2003-04-08

    申请号：US09914985

    申请日：2001-09-06

    申请人： Mark T. Bilodeau ,  Mark E. Fraley ,  Randall W. Hungate

    发明人： Mark T. Bilodeau ,  Mark E. Fraley ,  Randall W. Hungate

    IPC分类号： C07D48704

    CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/535 ,  A61K41/0038 ,  A61K45/06

    摘要： The present invention relates to pyrazolo-pyrimidinyl compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

    摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的吡唑并嘧啶基化合物，其含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤的方法 生长，动脉粥样硬化，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。