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    Medical devices having adherent polymeric layers with depth-dependent properties
    5.
    发明授权
    Medical devices having adherent polymeric layers with depth-dependent properties 有权
    具有与深度相关性质的贴壁聚合物层的医疗装置

    公开(公告)号：US07919137B2

    公开(公告)日：2011-04-05

    申请号：US11983952

    申请日：2007-11-13

    申请人： Derek Sutermeister ,  Jay Rassat ,  James Anderson

    发明人： Derek Sutermeister ,  Jay Rassat ,  James Anderson

    IPC分类号： A61L33/00 ,  C08J7/18

    CPC分类号： A61L31/10 ,  A61L31/14 ,  Y10T428/31678

    摘要： According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.

    摘要翻译： 根据本发明的一个方面，提供了一种形成医疗装置的方法，其包括：（a）使基底与含有（i）一种或多种聚合物的溶液接触，（ii）含有一种 或更多类型的溶剂物质，和（iii）一种或多种任选的试剂，例如一种或多种治疗剂等; 和（b）从溶液中除去溶剂，由此在基材上形成聚合物层。 在形成聚合物层的过程中改变溶液的组成。 在本发明的另一方面，提供了一种医疗装置，其包括衬底和在衬底上的聚合物层。 聚合物层含有含有不同的第一和第二单体的共聚物。 与基材接触的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。

    Hybrid bifurcated stent
    10.
    发明申请
    Hybrid bifurcated stent 审中-公开
    混合分叉支架

    公开(公告)号：US20070078511A1

    公开(公告)日：2007-04-05

    申请号：US11240313

    申请日：2005-09-30

    申请人： Timothy Ehr ,  Kenneth Merdan ,  Jay Rassat ,  Derek Sutermeister

    发明人： Timothy Ehr ,  Kenneth Merdan ,  Jay Rassat ,  Derek Sutermeister

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/88 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/067 ,  A61F2002/91508 ,  A61F2002/91533 ,  A61F2220/0091 ,  A61F2250/0039

    摘要： A stent assembly has a first stent body and a second stent body. The first stent body defines a first lumen having a first longitudinal axis therethrough, and the second stent body defines a second lumen having a second longitudinal axis therethrough. An end of the second stent body is hingedly engaged to a portion of the first stent body, and the first lumen and the second lumen are in fluid communication with one another. The stent assembly has a undeployed and a deployed state. In the undeployed state the first longitudinal axis and the second longitudinal axis are substantially parallel to one another and the second lumen is positioned entirely within the first lumen. In the deployed state the second longitudinal axis forms an oblique angle with the first longitudinal axis.

    摘要翻译： 支架组件具有第一支架主体和第二支架主体。 第一支架主体限定具有穿过其的第一纵向轴线的第一内腔，并且第二支架主体限定具有穿过其的第二纵向轴线的第二腔。 第二支架主体的端部铰接地接合到第一支架主体的一部分，并且第一管腔和第二管腔彼此流体连通。 支架组件具有未部署和部署状态。 在非部署状态下，第一纵向轴线和第二纵向轴线基本上彼此平行并且第二管腔完全位于第一管腔内。 在展开状态下，第二纵向轴线与第一纵向轴线形成倾斜角度。