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公开(公告)号：US07985841B2
公开(公告)日：2011-07-26
申请号：US11315970
申请日：2005-12-22
申请人： Angray Kang , Carlos F. Barbas , Richard A. Lerner
发明人： Angray Kang , Carlos F. Barbas , Richard A. Lerner
IPC分类号： C12P21/08
CPC分类号： C40B40/02 , C07K14/705 , C07K16/00 , C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2319/02 , C12N15/1037 , C12P19/34
摘要： Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor comprised of the first and second polypeptides surface-integrated into the matrix via a filamentous phage coat protein membrane anchor domain fused to at least one of the polypeptides.
摘要翻译： 丝状噬菌体包含cpVIII蛋白质基质，其包封编码独组织受体（例如抗体）的第一和第二多肽的基因组，以及由第一和第二多肽组成的受体，其通过丝状噬菌体蛋白膜表面整合到基质中 锚结构域与至少一个多肽融合。
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公开(公告)号：US07118866B2
公开(公告)日：2006-10-10
申请号：US10273973
申请日：2002-10-18
IPC分类号： C12Q1/68
CPC分类号： C40B40/02 , C07K14/705 , C07K16/00 , C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2319/02 , C12N15/1037 , C12P19/34
摘要： Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor comprised of the first and second polypeptides surface-integrated into the matrix via a filamentous phage coat protein membrane anchor domain fused to at least one of the polypeptides.
摘要翻译： 丝状噬菌体包含cpVIII蛋白质基质，其包封编码独组织受体（例如抗体）的第一和第二多肽的基因组，以及由第一和第二多肽组成的受体，其通过丝状噬菌体蛋白膜表面整合到基质中 锚结构域与至少一个多肽融合。
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公开(公告)号：US06268488B1
公开(公告)日：2001-07-31
申请号：US09318661
申请日：1999-05-25
IPC分类号： C07H1524
CPC分类号： C07H15/252
摘要： The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
摘要翻译： 本发明提供了一种化合物，其包含与对具有后 - 醛醇缩合反应的分子的催化作用敏感的阻断部分连接的活性治疗剂和复合迈克尔催化活性，制备这种化合物的方法和将这些化合物转化为活性的方法 使用具有醛缩酶活性的分子的治疗剂。
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4.发明授权Methods for producing polypeptide metal binding sites and compositions thereof 失效产生多肽金属结合位点的方法及其组合物
公开(公告)号：US5679548A
公开(公告)日：1997-10-21
申请号：US77797
申请日：1993-06-14
CPC分类号： C40B40/02 , C07H21/00 , C07K16/00 , C07K16/40 , C12N15/1037 , C07K2317/55
摘要： The present invention describes methods for producing metal binding sites on polypeptides, and particularly for producing metal binding sites within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles. The invention also describes oligonucleotides useful for preparing the metal binding sites, and human monoclonal antibodies produced by the present methods.
摘要翻译： 本发明描述了在多肽上产生金属结合位点的方法，特别是用于在显示在丝状噬菌体颗粒表面上的免疫球蛋白重链或轻链的CDR区内产生金属结合位点的方法。 本发明还描述了可用于制备金属结合位点的寡核苷酸以及通过本发明方法产生的人单克隆抗体。
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公开(公告)号：US08252902B2
公开(公告)日：2012-08-28
申请号：US10278364
申请日：2002-10-22
IPC分类号： C07K16/00
CPC分类号： A61K49/0058 , A61K47/54 , A61K47/545 , A61K47/642 , A61K47/66 , A61K47/6813 , A61K47/6871 , A61K47/6881 , A61K47/6889 , B82Y5/00 , C07D475/04 , C07K5/0817 , C07K7/06 , C07K14/005 , C07K14/47 , C07K14/5406 , C07K14/575 , C07K14/71 , C07K16/40 , C12N9/0002 , C12N15/115 , C12N2740/16022
摘要： The present invention provides antibody targeting compounds in which the specificity of the antibody has been reprogrammed by covalently or noncovalently linking a targeting agent to the combining site of an antibody. By this approach, the covalently modified antibody takes on the binding specificity of the targeting agent. The compound may have biological activity provided by the targeting agent or by a separate biological agent. Various uses of the invention compounds are provided.
摘要翻译： 本发明提供抗体靶向化合物，其中抗体的特异性已通过共价或非共价连接靶向剂与抗体的结合位点重新编程。 通过这种方法，共价修饰的抗体具有靶向剂的结合特异性。 化合物可以具有由靶向剂或单独的生物制剂提供的生物活性。 提供本发明化合物的各种用途。
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公开(公告)号：US5733757A
公开(公告)日：1998-03-31
申请号：US573415
申请日：1995-12-15
IPC分类号： C07C45/45 , C07C231/12 , C07C233/33 , C07K16/44 , C12N5/10 , C12N5/18 , C12N9/00 , C12N9/88 , C12N15/06 , C12P7/26 , C12P13/00 , C12P21/08 , C12N5/12
CPC分类号： C12P7/26 , C12N9/0002 , C12N9/88 , G01N2333/901
摘要： Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.
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7.发明授权公开(公告)号：US07666658B1
公开(公告)日：2010-02-23
申请号：US10110181
申请日：2000-10-06
申请人： Carlos F. Barbas , Richard A. Lerner , Guofu Zhong
发明人： Carlos F. Barbas , Richard A. Lerner , Guofu Zhong
CPC分类号： C07D277/24 , C07B57/00 , C07B2200/07 , C07D277/34 , C07D277/36 , C07D417/06 , C07D493/04 , C12N9/0002 , C12P7/26 , C12P13/02 , C12P41/00 , C12P41/002
摘要： Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.
摘要翻译： 使用半抗原2产生九种有效的醛缩酶抗体。该半抗原在单个分子中结合用于反应性免疫的结构组分与用于形成醛醇反应的过渡态类似物的结构组分。 这些抗体中的两种的表征显示它们是非常熟练的（比任何其他抗体催化剂优于1000倍）和对映体选择性催化剂，用于醛醇醛和醛缩醇反应，并显示与抗体38C2相反的对映体和非对映体选择性。
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8.发明授权公开(公告)号：US07067284B1
公开(公告)日：2006-06-27
申请号：US09610551
申请日：2000-07-05
CPC分类号： C07K16/005 , C07K16/40 , C07K16/44 , C07K2317/55 , C07K2317/565 , C12N15/102 , C12N15/1086 , C12N15/1093
摘要： The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
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公开(公告)号：US06589766B1
公开(公告)日：2003-07-08
申请号：US09965512
申请日：2001-09-25
IPC分类号： C12P726
CPC分类号： C12P7/26 , C12N9/0002
摘要： Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products. A number of intramolecular aldol reactions have also been defined. Catalysis of all intramolecular aldol reactions examined yields the corresponding condensation products.
摘要翻译： 包括38C2和33F12在内的催化抗体能够有效地催化各种酮 - 酮，酮 - 醛，醛 - 酮和醛 - 醛分子间醛醇反应，并且在某些情况下催化它们随后的脱水以产生醛醇缩合 产品。 还定义了许多分子内醛醇反应。 所检测的所有分子内醛醇反应的催化产生相应的缩合产物。
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公开(公告)号：US06326176B1
公开(公告)日：2001-12-04
申请号：US09573753
申请日：2000-05-18
IPC分类号： C12P726
CPC分类号： C12P7/26 , C12N9/0002
摘要： Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products. A number of intramolecular aldol reactions have also been defined. Catalysis of all intramolecular aldol reactions examined yields the corresponding condensation products.
摘要翻译： 包括38C2和33F12在内的催化抗体能够有效地催化各种酮 - 酮，酮 - 醛，醛 - 酮和醛 - 醛分子间醛醇反应，并且在某些情况下催化它们随后的脱水以产生醛醇缩合 产品。 还定义了许多分子内醛醇反应。 所检测的所有分子内醛醇反应的催化产生相应的缩合产物。
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