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1.发明申请公开(公告)号：US20090143766A1
公开(公告)日：2009-06-04
申请号：US12320613
申请日：2009-01-29
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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2.发明授权公开(公告)号：US07465766B2
公开(公告)日：2008-12-16
申请号：US11176544
申请日：2005-07-07
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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3.发明授权公开(公告)号：US08207262B2
公开(公告)日：2012-06-26
申请号：US12283661
申请日：2008-09-15
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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公开(公告)号：US20090142309A1
公开(公告)日：2009-06-04
申请号：US12320609
申请日：2009-01-29
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08J3/246 , C08B37/0072 , C08G73/02 , C08H1/00 , C08J3/24 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
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公开(公告)号：US20090042294A1
公开(公告)日：2009-02-12
申请号：US12283661
申请日：2008-09-15
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
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6.发明申请公开(公告)号：US20060084759A1
公开(公告)日：2006-04-20
申请号：US11176544
申请日：2005-07-07
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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7.发明授权Method and instruments for positioning humeral component during shoulder arthroplasty 有权肩关节成形术中定位肱骨组件的方法和仪器公开(公告)号：US08545504B2
公开(公告)日：2013-10-01
申请号：US12690671
申请日：2010-01-20
申请人： Anitra Durand-Allen , Roy C. Wiley , Louis Bigliani , Evan Flatow , Ian Kelly , George McCluskey , Anthony Miniaci , Gregory Nicholson , Michael Pearl , Ken Yamaguchi
发明人： Anitra Durand-Allen , Roy C. Wiley , Louis Bigliani , Evan Flatow , Ian Kelly , George McCluskey , Anthony Miniaci , Gregory Nicholson , Michael Pearl , Ken Yamaguchi
IPC分类号： A61F2/46
CPC分类号： A61B17/862 , A61B17/1778 , A61B17/8883 , A61F2/30734 , A61F2/40 , A61F2/4059 , A61F2/4612 , A61F2/4657 , A61F2/4684 , A61F2002/30616 , A61F2002/30617 , A61F2002/30708 , A61F2002/30713 , A61F2002/30884 , A61F2002/30896 , A61F2002/4018 , A61F2002/4033 , A61F2002/4051 , A61F2002/4062 , A61F2002/4631 , A61F2002/4658 , A61F2002/4687 , A61F2250/0084 , A61F2250/0087 , A61F2250/0097
摘要： The present invention relates to a set of tools and accessories used for properly positioning a stemmed humeral component, and/or a humeral stem provisional, within a canal in the humerus. The set of tools and accessories includes one or more fin clamps that are configured to be temporarily attached to a fin on the humeral component or the provisional; a ruler that is configured to be attached to the arm of the fin clamp, a fixation pin and pin driver configured to be used with the other tools for marking a position on the humerus; and one or more sleeves that are configured to slide over the stem of the humeral stem provisional to maintain it in the desired position.
摘要翻译： 本发明涉及一种用于在肱骨的管道内适当地定位肱骨头部件和/或肱骨静脉的工具和附件。 一组工具和附件包括一个或多个翅片夹，其被配置为临时附接到肱骨部件上的翅片或临时的; 被配置为附接到所述翅片夹的臂的标尺，固定销和销驱动器，其被配置为与用于标记所述肱骨上的位置的其它工具一起使用; 以及构造成在肱骨柄的杆上滑动以临时使其保持在期望位置的一个或多个套筒。
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公开(公告)号：US20110071641A1
公开(公告)日：2011-03-24
申请号：US12942923
申请日：2010-11-09
申请人： Steven W. Ek , Anthony Miniaci
发明人： Steven W. Ek , Anthony Miniaci
CPC分类号： A61F2/30 , A61B17/1662 , A61B17/1664 , A61B17/1675 , A61B17/1684 , A61F2/3603 , A61F2/389 , A61F2/4607 , A61F2/461 , A61F2/4618 , A61F2002/30827 , A61F2002/4007 , A61F2002/4635 , A61F2002/4636 , A61F2002/4677 , A61F2310/00017 , A61F2310/00023
摘要： A method is provided for delivering an implant for replacing a portion of an articular surface. The method may include forming a socket in an articulating feature that is capable of moving relative to the articular surface. An implant may be placed in the socket and the articulating feature may be moved relative to the articular surface to generally align the socket with an implant site formed in the articular surface. The implant may be transferred from the socket into the implant site.
摘要翻译： 提供了一种用于输送用于替换关节表面的一部分的植入物的方法。 该方法可以包括在能够相对于关节表面移动的关节特征中形成插座。 植入物可以放置在插座中，并且关节特征可以相对于关节表面移动，以将插座大致对准在关节表面中形成的植入部位。 植入物可以从插座转移到植入部位。
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公开(公告)号：US07901408B2
公开(公告)日：2011-03-08
申请号：US11209170
申请日：2005-08-22
申请人： Steven W. Ek , Tim Brightman , Anthony Miniaci
发明人： Steven W. Ek , Tim Brightman , Anthony Miniaci
CPC分类号： A61F2/30756 , A61B17/1637 , A61B17/1684 , A61B17/17 , A61B17/1714 , A61B17/1735 , A61B17/175 , A61B17/1778 , A61F2/3601 , A61F2/4003 , A61F2002/30299 , A61F2002/30332 , A61F2002/3085 , A61F2002/4007 , A61F2002/4631 , A61F2220/0033 , A61F2230/0093
摘要： A system and method may be used for accessing an articular surface and for preparing an implant site on the articular surface. The method may include locating a portion of the articular. An access passage may be drilled towards the articular surface though bone behind the articular surface. An implant site may be excised in the articular surface relative to an axis defined by the access passage.
摘要翻译： 可以使用系统和方法来访问关节表面并且用于在关节表面上准备植入部位。 该方法可以包括定位关节的一部分。 可以通过关节表面后面的骨头朝向关节表面钻取入通道。 可以在关节表面中相对于由进入通道限定的轴线切除植入部位。
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公开(公告)号：US06146385A
公开(公告)日：2000-11-14
申请号：US799697
申请日：1997-02-11
申请人： Paul A. Torrie , Michael C. Ferragamo , Rebecca Blough , Anthony Miniaci , Lazlo Hangody , Zoltan Karparti
发明人： Paul A. Torrie , Michael C. Ferragamo , Rebecca Blough , Anthony Miniaci , Lazlo Hangody , Zoltan Karparti
IPC分类号： A61B17/16 , A61B17/17 , A61B17/90 , A61B19/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/46
CPC分类号： A61B17/1635 , A61F2/30756 , A61F2/4601 , A61F2/4657 , A61B17/175 , A61B2090/062 , A61F2/3859 , A61F2/4618 , A61F2002/2839 , A61F2002/4623 , A61F2002/4649 , A61F2002/4658 , A61F2002/4659 , A61F2310/00964
摘要： A method of repairing cartilage (e.g., articular cartilage on the femur) and a set of instruments used in the method are provided. The damaged cartilage is removed from the bone to expose the underlying bone, grafts covered with cartilage (e.g., hyaline cartilage) are harvested from elsewhere in the body (e.g., other areas of the femur), and the grafts are inserted into holes drilled into the exposed area of bone. A guide is provided for use with surgical instruments during the procedure to orient the surgical instruments perpendicularly to the bone surface during use. The guide includes a guiding portion disposed along a longitudinal axis for engaging the surgical instrument, and a tissue-engaging portion oriented perpendicularly to the longitudinal axis. A set of surgical instruments used to carry out the method includes the guide, a drill for forming the graft-receiving holes, and an insertion tool for inserting the grafts. Other accessory instruments are also provided.
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