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公开(公告)号：US20090123435A1
公开(公告)日：2009-05-14
申请号：US12239458
申请日：2008-09-26
申请人： Anthony Ratcliffe , Jonathan Noel Mansbridge , Lee K. Landeen , Emmett Pinney , Linette J. Edison
发明人： Anthony Ratcliffe , Jonathan Noel Mansbridge , Lee K. Landeen , Emmett Pinney , Linette J. Edison
CPC分类号： C12N5/0062 , A61K31/00 , A61K31/715 , A61K35/33 , A61K35/38 , C12N2501/415 , C12N2502/1323 , C12N2531/00 , C12N2533/40
摘要： The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
摘要翻译： 本公开提供可以使用微创方法施用于组织和器官的三维组织的组合物。 三维组织阐述了促进受损组织和器官修复或再生的生长因子谱。
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公开(公告)号：US20110033434A1
公开(公告)日：2011-02-10
申请号：US12874931
申请日：2010-09-02
申请人： Anthony Ratcliffe , Jonathan Noel Mansbridge , Lee K. Landeen , Emmett Pinney , Linette J. Edison
发明人： Anthony Ratcliffe , Jonathan Noel Mansbridge , Lee K. Landeen , Emmett Pinney , Linette J. Edison
IPC分类号： A61K35/12 , C12N5/071 , A61P9/00 , C12N5/077 , C12N5/0787 , C12N5/0786 , C12N5/078 , A61M25/00
CPC分类号： C12N5/0062 , A61K31/00 , A61K31/715 , A61K35/33 , A61K35/38 , C12N2501/415 , C12N2502/1323 , C12N2531/00 , C12N2533/40
摘要： The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
摘要翻译： 本公开提供可以使用微创方法施用于组织和器官的三维组织的组合物。 三维组织阐述了促进受损组织和器官修复或再生的生长因子谱。
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公开(公告)号：US20120230940A1
公开(公告)日：2012-09-13
申请号：US13417017
申请日：2012-03-09
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
IPC分类号： A61K35/12 , A61K38/18 , A61K31/506 , C12N5/073
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译： 描述了包含调节细胞培养基组合物和使用方法的新产品。 本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。 一旦本发明的细胞培养基被调节，它可以在任何状态下使用。 条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。 另外，介质配制有药学上可接受的载体作为用于内部施用的载体，直接施用于食品或产品，或用药膏或软膏配制用于局部应用。 此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。
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公开(公告)号：US20090123503A1
公开(公告)日：2009-05-14
申请号：US12349451
申请日：2009-01-06
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译： 描述了包含调节细胞培养基组合物和使用方法的新产品。 本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。 介质可以由基质细胞，实质细胞，间充质干细胞，肝储备细胞，神经干细胞，胰干细胞和/或胚胎干细胞调节。 另外，细胞可以被遗传修饰。 优选三维组织构建体。 一旦本发明的细胞培养基被调节，它可以在任何状态下使用。 条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。 另外，介质配制有药学上可接受的载体作为内部给药载体，直接施用于用药膏或软膏配制用于局部应用的食品或产品，或者例如制成或添加到手术胶中 通过侵入性手术加快缝合线愈合。 此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。
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公开(公告)号：US08138147B2
公开(公告)日：2012-03-20
申请号：US12349451
申请日：2009-01-06
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译： 描述了包含调节细胞培养基组合物和使用方法的新产品。 本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。 介质可以由基质细胞，实质细胞，间充质干细胞，肝储备细胞，神经干细胞，胰干细胞和/或胚胎干细胞调节。 另外，细胞可以被遗传修饰。 优选三维组织构建体。 一旦本发明的细胞培养基被调节，它可以在任何状态下使用。 条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。 另外，介质配制有药学上可接受的载体作为内部给药载体，直接施用于用药膏或软膏配制用于局部应用的食品或产品，或者例如制成或添加到手术胶中 通过侵入性手术加快缝合线愈合。 此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。
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公开(公告)号：US08476231B2
公开(公告)日：2013-07-02
申请号：US13417017
申请日：2012-03-09
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译： 描述了包含调节细胞培养基组合物和使用方法的新产品。 本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。 一旦本发明的细胞培养基被调节，它可以在任何状态下使用。 条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。 另外，介质配制有药学上可接受的载体作为用于内部施用的载体，直接施用于食品或产品，或用药膏或软膏配制用于局部应用。 此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。
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公开(公告)号：US08361485B2
公开(公告)日：2013-01-29
申请号：US11538380
申请日：2006-10-03
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译： 描述了包含调节细胞培养基组合物和使用方法的新产品。 本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。 介质可以由基质细胞，实质细胞，间充质干细胞，肝储备细胞，神经干细胞，胰干细胞和/或胚胎干细胞调节。 另外，细胞可以被遗传修饰。 优选三维组织构建体。 一旦本发明的细胞培养基被调节，它可以在任何状态下使用。 条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。 另外，介质配制有药学上可接受的载体作为内部给药载体，直接施用于用药膏或软膏配制用于局部应用的食品或产品，或者例如制成或添加到手术胶中 通过侵入性手术加快缝合线愈合。 此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。
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公开(公告)号：US07118746B1
公开(公告)日：2006-10-10
申请号：US09979813
申请日：2000-05-12
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
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公开(公告)号：US20060154365A1
公开(公告)日：2006-07-13
申请号：US11216574
申请日：2005-08-30
IPC分类号： C12N5/08
CPC分类号： A61Q7/00 , A61K8/99 , A61K31/506 , A61K35/33 , A61K35/36 , A61K38/18 , A61K38/1866 , A61K2800/91 , A61L27/3804 , A61L27/3869 , A61L27/58 , C12N5/0062 , C12N2501/415 , C12N2502/1323 , C12N2531/00 , C12N2533/40 , A61K2300/00
摘要： The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
摘要翻译： 本公开提供可以使用微创方法施用于组织和器官的三维组织的组合物。 三维组织阐述了促进受损组织和器官修复或再生的生长因子谱。
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公开(公告)号：US08574620B2
公开(公告)日：2013-11-05
申请号：US13099762
申请日：2011-05-03
申请人： Anthony Ratcliffe
发明人： Anthony Ratcliffe
IPC分类号： A61F13/00
CPC分类号： A61L26/0052 , A61F2/08 , A61F2/105 , A61F2/28 , A61F2/30756 , A61F2002/0894 , A61K31/77 , A61L26/008 , A61L27/48 , A61L27/50 , A61L27/52
摘要： The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.
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