利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

110 条记录 (耗时 0.08 秒)

    2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF
    1.
    发明申请
    2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF 审中-公开
    2-氨基-6-环丙氨基-3-（吡啶-4-基）咪唑并[1,2-B] - 吡啶衍生物，其制备方法及其治疗应用

    公开(公告)号：US20110312934A1

    公开(公告)日：2011-12-22

    申请号：US13058665

    申请日：2009-08-12

    申请人： Antonio Almario Garcia ,  Philippe Burnier ,  Sylvain Cote-Des Combes ,  Jean-François Gibert ,  Christophe Pacaud ,  Frédéric Puech ,  Yulin Chiang ,  Larry Davis ,  Zhongli Gao ,  Qiuxia Zhao

    发明人： Antonio Almario Garcia ,  Philippe Burnier ,  Sylvain Cote-Des Combes ,  Jean-François Gibert ,  Christophe Pacaud ,  Frédéric Puech ,  Yulin Chiang ,  Larry Davis ,  Zhongli Gao ,  Qiuxia Zhao

    IPC分类号： A61K31/551 ,  C07D498/10 ,  C07D471/08 ,  A61P25/30 ,  A61K31/5386 ,  A61P35/00 ,  A61P25/00 ,  C07D487/04 ,  A61K31/5025

    CPC分类号： C07D487/04 ,  C07D519/00

    摘要： The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy-C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl>C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, —NR4R5, hydroxyl or C1-4 alkyloxy groups; A is a C1-7-alkylene group optionally substituted by one or two Ra groups; B is a C1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1-6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-allyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.

    摘要翻译： 本发明涉及通式（I）的2-烷基-6-环氨基-3-（吡啶-4-基）咪唑并[1,2-b]哒嗪衍生物，其中：R2是C1-6烷基，C3 7-环烷基，C 3-7 - 环烷基-C 1-4 - 烷基，C 1-4 - 烷氧基-C1-烷基，C 3-7 - 环烷氧基-C 1-4 - 烷基，C 3-7 - 环烷基-C 1-4 - 烷氧基 C 1-4烷基，羟基-C 1-6 - 烷基，C 1-4 - 氟代烷基; R3是氢原子或选自卤素原子和C1-3烷基，-NR4R5，羟基或C1-4烷氧基的取代基; A是任选被一个或两个R a基团取代的C 1-7 - 亚烷基; B是任选被一个或两个Rb基团取代的C 1-7 - 亚烷基; L是任选被Rc或Rd基团取代的氮原子或被Re 1基团和Rd基团取代的碳原子或两个Re 2基团; Rd是选自氢原子或C 1-6 - 烷基，C 3-7 - 环烷基，C 3-7 - 环烷基-C 1-6 - 烷基，C 1-6 - 烷硫基-C 1-6 - 烷基，C 1-6 - 烷氧基-C 1-6 - 烷基，C 1-6 - 氟代烷基，羟基-C 1-6 - 烷基; R f是C 1-6 - 烷基，C 3-7 - 环烷基，C 3-7 - 环烷基-C 1-6 - 烷基，C 1-6 - 烷氧基-C 1-6 - 烷基，C 3-7 - 环烷氧基-C 1-4 - 烷基 C 3-7 - 环烷基-C 1-4 - 烷氧基-C 1-4 - 烷基，羟基-C 1-6 - 烯丙基，C 1-6 - 氟烷基或苄基。 本发明还涉及其制备方法及其治疗应用。

    Substrate module with high thermal conductivity and its fabrication method of same
    5.
    发明申请
    Substrate module with high thermal conductivity and its fabrication method of same 审中-公开
    具有高导热性的基板模块及其制造方法

    公开(公告)号：US20080017402A1

    公开(公告)日：2008-01-24

    申请号：US11822772

    申请日：2007-07-10

    申请人： Rong-Fon Huang ,  Hsu-Yuan Chang ,  Kuo-Ta Wu ,  Yulin Chiang

    发明人： Rong-Fon Huang ,  Hsu-Yuan Chang ,  Kuo-Ta Wu ,  Yulin Chiang

    IPC分类号： H05K1/00

    CPC分类号： H05K1/0206 ,  H05K1/0306 ,  H05K3/4611 ,  H05K3/4629 ,  H05K2201/09609 ,  H05K2201/09627 ,  H05K2201/09709

    摘要： A high thermal conductivity substrate includes multiple substrate material layers each having a first plane and a second plane opposite to the first plane, thermal conducting columns arranged in the substrate material layers and respectively extending through the first planes and second planes of each substrate material layer along its thickness direction, and multiple thermal conducting layers arranged on the first plane of each substrate material layer and the second plane of one substrate material layer that is to be disposed at the bottom side of the substrate and connected to the thermal conducting columns in the respective substrate material layers to form a horizontally and vertically distributed thermal conducting network.

    摘要翻译： 高导热性衬底包括多个衬底材料层，每个衬底材料层具有第一平面和与第一平面相对的第二平面，导热柱布置在衬底材料层中并分别延伸穿过每个衬底材料层的第一平面和第二平面 其厚度方向和布置在每个基底材料层的第一平面上的多个导热层和一个基底材料层的第二平面，该第二平面将被布置在基底的底部并连接到相应的导热柱 衬底材料层以形成水平和垂直分布的导热网络。