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公开(公告)号：US20100234364A1
公开(公告)日：2010-09-16
申请号：US12309329
申请日：2007-07-10
申请人： Arindrajit Basak , Jeff Jin , Jimmie Moore , Andrew M.K. Pennell , Sreenlvas Punna , Solomon Ungashe , Zheng Wei
发明人： Arindrajit Basak , Jeff Jin , Jimmie Moore , Andrew M.K. Pennell , Sreenlvas Punna , Solomon Ungashe , Zheng Wei
IPC分类号： A61K31/54 , C07C311/21 , A61K31/18 , C07D213/78 , A61K31/4409 , C07D265/30 , C07D263/32 , A61K31/5375 , A61K31/421 , C07D213/42 , A61K31/4418 , C07D207/04 , A61K31/40 , C07D207/16 , C07D279/12 , C07D231/18 , A61K31/415 , A61P29/00 , A61P37/00
CPC分类号： A61K31/44 , A61K31/47 , A61K31/5375 , C07C311/21 , C07D207/16 , C07D213/42 , C07D213/50 , C07D231/12 , C07D263/32 , C07D295/108 , C07D295/192
摘要： Compounds are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, CCR9-mediated diseases, as controls in assays for the identification of CCR2 antagonists, and as controls in assays for the identification of CCR9 antagonists.
摘要翻译： 提供了作为CCR2或CCR9受体的有效拮抗剂的化合物。 动物试验表明，这些化合物可用于治疗炎症，CCR2和CCR9的标志性疾病。 化合物通常是芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，CCR9介导的疾病，作为用于鉴定CCR2拮抗剂的测定中的对照，以及用于鉴定CCR9的测定中的对照 拮抗剂
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公开(公告)号：US20100056509A1
公开(公告)日：2010-03-04
申请号：US12582001
申请日：2009-10-20
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M.K. Pennell , John J. Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M.K. Pennell , John J. Wright
IPC分类号： A61K31/5377 , C07D471/02 , C07D401/06 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D413/06 , C07D498/02
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US20070037794A1
公开(公告)日：2007-02-15
申请号：US11486974
申请日：2006-07-14
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/444 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US20060173019A1
公开(公告)日：2006-08-03
申请号：US11332786
申请日：2006-01-13
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
IPC分类号： A61K31/496 , A61K31/4545 , C07D403/02 , C07D401/02
CPC分类号： C07C311/21 , C07D213/48 , C07D213/61 , C07D213/643 , C07D213/70 , C07D213/73 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/89 , C07D241/22 , C07D263/32 , C07D401/04 , C07D405/04 , C07D409/12 , C07D413/06 , C07D413/10 , C07D417/12 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号：US07622583B2
公开(公告)日：2009-11-24
申请号：US11486974
申请日：2006-07-14
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
IPC分类号： C07D471/02 , C07D237/00 , A61K31/495 , A61K31/44
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US08093247B2
公开(公告)日：2012-01-10
申请号：US12582001
申请日：2009-10-20
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US20110118248A1
公开(公告)日：2011-05-19
申请号：US12309314
申请日：2009-01-13
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/538 , C07C311/29 , C07D213/76 , C07D401/12 , C07D401/06 , C07D413/06 , C07D405/04 , C07D471/04 , C07D417/12 , C07D498/04 , C07D401/04 , C07D413/10 , C07D401/10 , A61K31/18 , A61K31/44 , A61K31/444 , A61K31/443 , A61K31/5377 , A61K31/4375 , A61K31/4439 , A61K31/5383 , A61K31/517 , A61K31/437 , A61K31/502 , A61K31/519 , C12N5/071 , A61P9/10 , A61P9/00 , A61P25/28 , A61P29/00 , A61P3/04 , A61P3/10 , A61P13/12 , A61P1/00 , A61P11/00 , A61P37/06 , A61P35/00 , A61P25/04
CPC分类号： A61K31/5383 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4965 , A61K31/502 , A61K31/5377 , A61K31/538 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US07714167B2
公开(公告)日：2010-05-11
申请号：US11656891
申请日：2007-01-22
申请人： Hisashi Yamamoto , Arindrajit Basak , Wei Zhang
发明人： Hisashi Yamamoto , Arindrajit Basak , Wei Zhang
IPC分类号： C07C239/14 , C07C315/02 , C07F9/53
CPC分类号： C07D303/14 , B01J31/006 , B01J31/0201 , B01J31/2213 , B01J31/2226 , B01J31/2234 , B01J2231/70 , B01J2231/72 , B01J2531/0266 , B01J2531/56 , B01J2531/64 , B01J2540/34 , C07D301/14
摘要： The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.
摘要翻译： 本发明涉及通过烯烃的催化不对称氧化合成手性环氧化物。 另外，该方法提供了一种不对称氧化硫化物和膦的方法。 这种不对称氧化采用由金属和手性双硅氧酸配体组成的催化剂体系，其在化学计量氧化试剂的存在下用于不对称地氧化各种底物。
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公开(公告)号：US20050159607A1
公开(公告)日：2005-07-21
申请号：US10762028
申请日：2004-01-20
申请人： Hisashi Yamamoto , Arindrajit Basak , Wei Zhang
发明人： Hisashi Yamamoto , Arindrajit Basak , Wei Zhang
IPC分类号： B01J31/18 , C07D301/12 , C07D301/14 , C07D303/14 , C07D301/16 , C07C259/04 , C07F9/00
CPC分类号： C07D303/14 , B01J31/006 , B01J31/0201 , B01J31/2213 , B01J31/2226 , B01J31/2234 , B01J2231/70 , B01J2231/72 , B01J2531/0266 , B01J2531/56 , B01J2531/64 , B01J2540/34 , C07D301/14
摘要： The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.
摘要翻译： 本发明涉及通过烯烃的催化不对称氧化合成手性环氧化物。 另外，该方法提供了一种不对称氧化硫化物和膦的方法。 这种不对称氧化采用由金属和手性双硅氧酸配体组成的催化剂体系，其在化学计量氧化试剂的存在下用于不对称地氧化各种底物。
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公开(公告)号：US20070203347A1
公开(公告)日：2007-08-30
申请号：US11656891
申请日：2007-01-22
申请人： Hisashi Yamamoto , Arindrajit Basak , Wei Zhang
发明人： Hisashi Yamamoto , Arindrajit Basak , Wei Zhang
IPC分类号： C07D301/19 , C07F11/00
CPC分类号： C07D303/14 , B01J31/006 , B01J31/0201 , B01J31/2213 , B01J31/2226 , B01J31/2234 , B01J2231/70 , B01J2231/72 , B01J2531/0266 , B01J2531/56 , B01J2531/64 , B01J2540/34 , C07D301/14
摘要： The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.
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