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31 条记录 (耗时 0.034 秒)

    System for metering nutrient media to cell culture containers and method
    4.
    发明授权
    System for metering nutrient media to cell culture containers and method 失效
    用于计量营养培养基至细胞培养容器和方法的系统

    公开(公告)号：US4829002A

    公开(公告)日：1989-05-09

    申请号：US862344

    申请日：1986-05-12

    申请人： Martha C. Pattillo ,  David V. Bacehowski ,  Arnold C. Bilstad ,  Herbert M. Cullis ,  T. Michael Dennehey ,  James W. Yang ,  William C. Brown

    发明人： Martha C. Pattillo ,  David V. Bacehowski ,  Arnold C. Bilstad ,  Herbert M. Cullis ,  T. Michael Dennehey ,  James W. Yang ,  William C. Brown

    IPC分类号： C12M3/00 ,  C12M1/00 ,  C12M1/26 ,  C12N5/00 ,  C12N5/10

    CPC分类号： C12M23/14 ,  C12M33/07

    摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.

    摘要翻译： 用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。 在优选的实施方案中，无菌连接器可用于基本上无菌的条件。 分支导管在与端部间隔开的位置处从流动管道延伸。 分支管道与用于从所述一端通过介质流动管道接收预定​​体积等分的介质的装置连通。 流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。 与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚

    Method for metering nutrient media to cell culture containers
    5.
    发明授权
    Method for metering nutrient media to cell culture containers 失效
    计量营养培养基至细胞培养容器的方法

    公开(公告)号：US4937194A

    公开(公告)日：1990-06-26

    申请号：US303188

    申请日：1989-01-30

    申请人： Martha C. Pattillo ,  David V. Bacehowski ,  Arnold C. Bilstad ,  Herbert M. Cullis ,  T. Michael Dennehey ,  James W. Yang ,  William C. Brown

    发明人： Martha C. Pattillo ,  David V. Bacehowski ,  Arnold C. Bilstad ,  Herbert M. Cullis ,  T. Michael Dennehey ,  James W. Yang ,  William C. Brown

    IPC分类号： C12M1/00 ,  C12M1/26 ,  C12N5/02

    CPC分类号： C12M23/14 ,  C12M33/07 ,  Y10S435/80

    摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.

    摘要翻译： 用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。 在优选的实施方案中，无菌连接器可用于基本上无菌的条件。 分支导管在与端部间隔开的位置处从流动管道延伸。 分支管道与用于从所述一端通过介质流动管道接收预定​​体积等分的介质的装置连通。 流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。 与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚

    Tube connector
    7.
    发明授权
    Tube connector 失效
    管接头

    公开(公告)号：US4439188A

    公开(公告)日：1984-03-27

    申请号：US378029

    申请日：1982-05-13

    申请人： T. Michael Dennehey ,  Richard J. Greff ,  Ludwig Wolf, Jr.

    发明人： T. Michael Dennehey ,  Richard J. Greff ,  Ludwig Wolf, Jr.

    IPC分类号： A61J1/00 ,  A61J1/14 ,  A61M1/28 ,  A61M5/14 ,  A61M39/00 ,  A61M39/10 ,  A61M5/00

    CPC分类号： A61M39/00 ,  A61J1/00 ,  A61M39/10 ,  A61M5/14 ,  A61J1/14 ,  A61M1/28 ,  A61M2039/1033

    摘要： Equipment for continuous ambulatory peritoneal dialysis in which a solution container is coupled via flexible tubing to a patient's tube that communicates with the patient's peritoneal cavity by means of a catheter, usually a surgically implanted catheter. The equipment includes a flexible, foldable plastic dialysis solution container having a transfer port. A flexible tube having a luer connector at its distal end extends from the transfer port, for connecting to a luer connector carried by the patient's tube. The flexible tube carries a frangible member which normally blocks fluid flow but permits fluid flow after the frangible member is broken. A particulate filter and a manually-operable clamp are in series with the flexible tube.Peritoneal dialysis is accomplished by connecting the luer connector from a fresh dialysis solution bag to the patient's tube luer connector, breaking the frangible member, and opening the clamp on the flexible tubing. After the dialysis solution is introduced into the patient's peritoneal cavity and remains there for a predetermined time, the solution is drained back into the flexible bag, the luer connectors are disconnected and the foregoing steps are repeated. If desired, once the dialysis solution has been introduced into the patient's peritoneal cavity, the luer connections may be disconnected and the patient's tube luer connector may be capped.

    摘要翻译： 用于连续不卧床腹膜透析的设备，其中溶液容器通过柔性管连接到通过导管（通常是手术植入的导管）与患者的腹膜腔连通的患者管。 该设备包括具有转移口的柔性可折叠塑料透析溶液容器。 在其远端处具有鲁尔连接器的柔性管从传送端口延伸，用于连接到患者管所承载的鲁尔连接器。 柔性管带有易碎构件，其通常阻挡流体流动，但在易碎构件破裂之后允许流体流动。 微粒过滤器和可手动操作的夹具与柔性管串联。 腹膜透析是通过将鲁尔连接器从新鲜透析溶液袋连接到患者管路鲁尔连接器，破坏易碎构件，以及将柔性管上的夹子打开来实现的。 将透析溶液引入患者的腹膜腔内并保持在预定时间之后，将溶液排回到柔性袋中，将鲁尔连接器断开并重复上述步骤。 如果需要，一旦透析溶液已经被引入到患者的腹膜腔中，则路厄氏连接可能被断开并且患者的管路鲁尔连接器可能被封盖。

    Luer lock connection device
    8.
    发明授权
    Luer lock connection device 失效
    鲁尔锁定连接装置

    公开(公告)号：US4294250A

    公开(公告)日：1981-10-13

    申请号：US101246

    申请日：1979-12-07

    申请人： T. Michael Dennehey

    发明人： T. Michael Dennehey

    IPC分类号： A61M39/02 ,  A61M1/00 ,  A61M39/10 ,  A61M3/00

    CPC分类号： A61M39/10 ,  A61M2039/1033 ,  Y10S604/905

    摘要： A luer lock connection device for medical use, for example, in continuous ambulatory peritoneal dialysis in which a solution container is coupled via flexible tubing to a patient's tube that communicates with the patient's peritoneal cavity.The luer lock connection device includes a cooperating male luer lock connector and a female luer lock connector, with visual indicating means provided to indicate that the male and female connectors are assembled properly for use when they are in a predetermined relationship. The male and female luer lock connectors are structured to provide a double sealing arrangement for aiding in maintaining an uncontaminated connection.

    摘要翻译： 用于医疗用途的路厄锁定连接装置，例如在连续不卧床腹膜透析中，其中溶液容器通过柔性管连接到与患者腹膜腔连通的患者管。 路厄锁定连接装置包括配合的公鲁尔锁定连接器和母路厄锁定连接器，其中设有视觉指示装置，用于指示阳型和阴性连接器在它们处于预定关系时被正确组装以供使用。 阳和鲁尔锁定连接器被构造成提供双重密封装置，以帮助维持未受污染的连接。

    Gripper member for retention of a plastic tube
    9.
    发明授权
    Gripper member for retention of a plastic tube 失效
    夹具用于保持塑料管

    公开(公告)号：US4227730A

    公开(公告)日：1980-10-14

    申请号：US43061

    申请日：1979-05-29

    申请人： John B. Alexander ,  T. Michael Dennehey ,  Richard J. Greff ,  John M. Munsch

    发明人： John B. Alexander ,  T. Michael Dennehey ,  Richard J. Greff ,  John M. Munsch

    IPC分类号： A61B17/122 ,  A61B17/28 ,  B25B9/02 ,  B25B7/02

    CPC分类号： B25B9/02 ,  A61B17/122 ,  A61B17/2812

    摘要： A gripper member comprises an openable and closable pair of handles interconnected by a hinge member. Each handle defines, adjacent its hinge member, an arcuate recess positioned to face the corresponding recess of the other handle and defining gripping projections therein. A wall member is positioned longitudinally on each handle to cross each arcuate recess, both wall members being positioned at the same side of their respective recesses. Accordingly, a plastic tube may be surrounded and gripped in the arcuate recesses of the handles for rotational retention thereof as a connector member is inserted into or withdrawn from the tube. At the same time, the wall members pinch the tube into closed, sealed relation with the handles in closed position.

    摘要翻译： 夹持器构件包括由铰链构件互连的可打开和可关闭的一对把手。 每个手柄在其铰链构件附近限定了一个弧形凹槽，其定位成面对另一个手柄的相应凹部并且在其中限定夹紧突起。 壁构件纵向地定位在每个手柄上以横穿每个弓形凹部，两个壁构件都位于它们各自的凹部的同一侧。 因此，当连接器构件被插入或从管中取出时，塑料管可以被包围并夹在手柄的弓形凹部中以用于旋转保持。 同时，壁构件将管子夹紧到处于关闭位置的把手处于封闭的密封关系中。

    Small volume collection chamber
    10.
    发明授权
    Small volume collection chamber 失效
    小容量收集室

    公开(公告)号：US5224921A

    公开(公告)日：1993-07-06

    申请号：US531175

    申请日：1990-05-31

    申请人： T. Michael Dennehey ,  Joseph C. West, Jr.

    发明人： T. Michael Dennehey ,  Joseph C. West, Jr.

    IPC分类号： B04B5/02 ,  A61M1/02 ,  A61M1/36 ,  B04B5/04

    CPC分类号： A61M1/3693 ,  A61M1/3696 ,  B04B5/0428 ,  B04B5/0442 ,  A61M2202/0415

    摘要： A device and method are provided for separating mononuclear cells from red blood cell depleted plasma in a centrifuge blood cell separator. The device includes an inlet for receiving plasma, an area for receiving mononuclear cells, and an outlet for receiving mononuclear cell depleted plasma. The distance and flow path between the inlet and outlet being so constructed and arranged as to cause mononuclear cells to sediment out into the area for receiving the mononuclear cells and causing at least 66% of the platelets contained in the plasma to flow to and through the outlet.

    摘要翻译： 提供了一种用于在离心机血细胞分离器中将单核细胞与红细胞消耗的血浆分离的装置和方法。 该装置包括用于接收血浆的入口，用于接收单核细胞的区域和用于接收单核细胞耗尽的血浆的出口。 入口和出口之间的距离和流动路径被构造和布置成使得单核细胞沉淀到用于接收单核细胞的区域中，并且使血浆中包含的至少66％的血小板流入并通过 出口。