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公开(公告)号：US07569364B2
公开(公告)日：2009-08-04
申请号：US11104248
申请日：2005-04-11
IPC分类号： A61K39/395 , A61P19/02 , A61P29/02 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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公开(公告)号：US20080182978A1
公开(公告)日：2008-07-31
申请号：US11104248
申请日：2005-04-11
IPC分类号： C07K16/18
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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公开(公告)号：US20100254990A1
公开(公告)日：2010-10-07
申请号：US12755279
申请日：2010-04-06
申请人： David L. Shelton
发明人： David L. Shelton
IPC分类号： A61K39/395 , A61P11/06 , A61P21/00 , A61P19/02 , A61P17/06
CPC分类号： C07K16/22 , A61K31/573 , A61K39/3955 , A61K39/39566 , A61K2039/505 , A61K2039/507 , C07K16/241 , C07K16/4291 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates generally to methods of using anti-NGF antibodies in the treatment of various NGF-related disorders, including asthma, arthritis and psoriasis. The methods are effective in treating these disorder in a patient without having a significant adverse effect on the immune system of the patient.
摘要翻译： 本发明一般涉及使用抗NGF抗体治疗各种NGF相关疾病（包括哮喘，关节炎和牛皮癣）的方法。 所述方法在治疗患者的这些疾病中是有效的，而不会对患者的免疫系统产生显着的不利影响。
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4.发明授权Methods for treating bone cancer pain by administering a nerve growth factor antagonist 有权通过施用神经生长因子拮抗剂治疗骨癌疼痛的方法公开(公告)号：US07425329B2
公开(公告)日：2008-09-16
申请号：US11102201
申请日：2005-04-07
IPC分类号： A61K39/395 , C07K16/22 , C12P21/08
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
摘要翻译： 本发明的特征在于通过施用神经生长因子（NGF）拮抗剂来预防或治疗包括与骨转移相关的癌症疼痛的骨癌疼痛的方法和组合物。 NGF拮抗剂可以是能够结合hNGF的抗NGF（例如抗hNGF）抗体。
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公开(公告)号：US20080182275A1
公开(公告)日：2008-07-31
申请号：US11786466
申请日：2007-04-10
申请人： Avi J Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Sophia S. Kuo , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , David L. Shelton , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi J Ashkenazi , Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Sophia S. Kuo , Mary A. Napier , James Pan , Nicholas F. Paoni , Margaret Ann Roy , David L. Shelton , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC分类号： G01N33/53 , C07H21/04 , C12N15/63 , C12N5/06 , C12N5/16 , C12N1/21 , C12N1/19 , C12P21/00 , C07K2/00 , C07K16/46 , C07K16/18 , G01N33/566
CPC分类号： C07K14/47 , G01N33/6872
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07384632B2
公开(公告)日：2008-06-10
申请号：US10312316
申请日：2001-06-22
IPC分类号： A61K39/00 , A61K39/395 , C12P21/08
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译： 本发明涉及模拟NT-3（trkC的天然配体）的某些生物学活性的激动剂抗-trkC单克隆抗体。 本发明还涉及这种抗体在预防和/或治疗细胞变性中的用途，包括与急性神经细胞系统损伤和慢性神经变性疾病（包括周围神经病变）相关的神经细胞损伤。
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公开(公告)号：US5891650A
公开(公告)日：1999-04-06
申请号：US441104
申请日：1995-05-15
IPC分类号： G01N33/48 , A61K38/00 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/28 , C12N9/12 , C12N15/09 , C12Q1/48 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/573 , G01N33/567
CPC分类号： C12N9/12 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/28 , C12Q1/485 , G01N33/54306 , G01N33/566 , G01N33/573 , A61K38/00 , G01N2333/705 , G01N2333/912 , G01N2333/9121 , G01N2500/00
摘要： An assay for measuring activation (i.e., autophosphorylation) of a tyrosine kinase receptor of interest is disclosed.(a) A first solid phase is coated with a substantially homogeneous population of cells so that the cells adhere to the first solid phase. The cells have either an endogenous tyrosine kinase receptor or have been transformed with DNA encoding a receptor or "receptor construct" and the DNA has been expressed so that the receptor or receptor construct is presented in the cell membranes of the cells.(b) A ligand is then added to the solid phase having the adhering cells, such that the tyrosine kinase receptor is exposed to the ligand.(c) Following exposure to the ligand, the adherent cells are solubilized, thereby releasing cell lysate.(d) A second solid phase is coated with a capture agent which binds specifically to the tyrosine kinase receptor, or, in the case of a receptor construct, to the flag polypeptide.(e) The cell lysate obtained in step (c) is added to the wells containing the adhering capture agent so as to capture the receptor or receptor construct to the wells.(f) A washing step is then carried out, so as to remove unbound cell lysate, leaving the captured receptor or receptor construct.(g) The captured receptor or receptor construct is exposed to a labelled anti-phosphotyrosine antibody which identifies phosphorylated residues in the tyrosine kinase receptor.(h) Binding of the anti-phosphotyrosine antibody to the captured receptor or receptor construct is measured.
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公开(公告)号：US4822604A
公开(公告)日：1989-04-18
申请号：US736011
申请日：1985-05-20
IPC分类号： A61K8/23 , A61K8/368 , A61K8/37 , A61K8/45 , A61K31/21 , A61K31/60 , A61Q5/00 , A61Q5/02 , C11D1/00 , A61K7/06
CPC分类号： A61K8/37 , A61K8/23 , A61K8/368 , A61K8/45 , A61Q5/006 , A61Q5/02 , A61K2800/52 , Y10S424/04 , Y10S514/864 , Y10S514/88 , Y10S514/881
摘要： A clear, therapeutic hair care composition is presented having a low pH and useful in the local treatment of dandruff, seborrheic dermatitis and psoriasis of the scalp which resists oxidative decomposition. The shampoo is comprised of a detergent shampoo base, a therapeutic amount of a keratolytic agent and a keratolytic stabilizing agent to stabilize the keratolytic agent against oxidative decoloration decomposition catalyzed by ultraviolet radiation exposure. The keratolytic agent is preferably a salicylate and preferably salicylic acid and the keratolytic stabilizing agent is a tertiary amine.
摘要翻译： 提供了一种具有低pH并且可用于头皮屑，脂溢性皮炎和头皮银屑病的局部治疗的清洁，治疗性护发组合物，其抗氧化分解。 洗发剂由洗涤剂洗发剂碱，治疗量的角质分解剂和角质层析稳定剂组成，以稳定角质层分离剂，防止紫外线照射引起的氧化脱色分解。 角质分解剂优选为水杨酸盐，优选水杨酸，角质分解稳定剂为叔胺。
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公开(公告)号：US20120045443A1
公开(公告)日：2012-02-23
申请号：US13198979
申请日：2011-08-05
IPC分类号： A61K39/395 , C12N15/13 , A61P25/28 , A61P25/00 , C12N5/10 , A61K31/7088 , C12N15/63 , C12N5/16 , C12N5/0793 , C12N1/21 , C07K16/28 , A61P25/02
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译： 本发明涉及模拟NT-3（trkC的天然配体）的某些生物学活性的激动剂抗-trkC单克隆抗体。 本发明还涉及这种抗体在预防和/或治疗细胞变性中的用途，包括与急性神经细胞系统损伤和慢性神经变性疾病（包括周围神经病变）相关的神经细胞损伤。
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10.发明授权Methods for treating pain by administering a nerve growth factor antagonist and an NSAID and compositions containing the same 有权通过施用神经生长因子拮抗剂和NSAID治疗疼痛的方法和含有它们的组合物公开(公告)号：US08034346B2
公开(公告)日：2011-10-11
申请号：US12644087
申请日：2009-12-22
IPC分类号： A61K39/395 , C07K16/22 , C12P21/06
CPC分类号： C07K16/22 , A61K31/192 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/76 , A61K2300/00
摘要： The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an NSAID and kits containing the same.
摘要翻译： 本发明的特征在于治疗或预防疼痛的方法，包括给予一定量的神经生长因子拮抗剂（例如抗NGF抗体）和一定量的NSAID，使得它们一起提供有效的疼痛缓解。 本发明还特征在于包含神经生长因子拮抗剂和NSAID的组合物以及含有其的试剂盒。
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