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    System for washing and processing of cells for delivery thereof to tissue
    3.
    发明授权
    System for washing and processing of cells for delivery thereof to tissue 失效
    用于洗涤和处理细胞以将其递送至组织的系统

    公开(公告)号：US07713232B2

    公开(公告)日：2010-05-11

    申请号：US11460635

    申请日：2006-07-28

    申请人： Arthur E. Uber, III ,  Frederick W. Trombley, III ,  Kevin P. Cowan ,  Mark Trocki

    发明人： Arthur E. Uber, III ,  Frederick W. Trombley, III ,  Kevin P. Cowan ,  Mark Trocki

    IPC分类号： G01N35/10

    CPC分类号： A61J1/1443 ,  A61J1/1456 ,  A61J1/1475 ,  A61M5/142 ,  A61M5/1723 ,  A61M5/3145 ,  A61M31/005 ,  B01L3/502 ,  B01L2300/044 ,  B01L2300/0681 ,  G06F19/3468

    摘要： A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

    摘要翻译： 用于将注射器注射到患者体内的系统包括用于保持注射器的第一可加压容器; 与所述第一可加压容器流体连接的患者接口，所述患者接口适于将所述注射器通入患者的组织; 动力注射器，其与所述第一可加压容器可操作地连接以对所述注射器加压; 与动力注射器操作连接的控制器系统; 以及适于与病人界面操作连接的立体定向定位框架，以协助控制患者界面的定位。 用于处理细胞（和/或其它注射组分）的系统​​包括适于可滑动地定位在容器内的容器和柱塞。 该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。 柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于经由入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物 港口。

    Syringes, syringe tubing and fluid transfer systems
    6.
    发明授权
    Syringes, syringe tubing and fluid transfer systems 有权
    注射器，注射器管和流体传输系统

    公开(公告)号：US06733477B2

    公开(公告)日：2004-05-11

    申请号：US09731108

    申请日：2000-12-06

    申请人： Kevin P. Cowan ,  Frederick W. Trombley, III ,  Mark Trocki ,  David M. Reilly

    发明人： Kevin P. Cowan ,  Frederick W. Trombley, III ,  Mark Trocki ,  David M. Reilly

    IPC分类号： A61M500

    CPC分类号： A61M5/14546 ,  A61M5/385 ,  A61M2005/1403

    摘要： A syringe includes a body and a plunger disposed therein. The body includes a nozzle formed therein and at least one hub member connected thereto or integrally formed thereon for holding an end of a connector tube. The connector tube includes two ends, each end preferably being connected to a respective hub member to retain the connector tube in contact with the syringe. Preferably, the syringe and the connector tube are packaged in a pre-connected condition for ease of use by the customer. Furthermore, flexible inlet tubing for connection to a syringe for filling the syringe with contrast media, for example, is described. The inlet tubing permits filling of the syringe from either a bag or a bottle and may remain attached to the syringe so that it forms at least a part of the connection to the patient. In addition, an apparatus for facilitating the purge of air from a connector tube that will ultimately be connected between a syringe and a patient is described. The apparatus includes a purging tube connected to the distal end of the connector tubing from the syringe. The purging tube includes a venting cap at its distal end. A flow inhibitor is positioned under the venting cap to cooperate with the venting cap by discouraging the discharge of fluid from the distal end of the purging tube while permitting the discharge of air therefrom.

    摘要翻译： 注射器包括主体和设置在其中的柱塞。 主体包括形成在其中的喷嘴和与其连接或一体地形成在其上的至少一个毂构件，用于保持连接器管的端部。 连接器管包括两个端部，每个端部优选地连接到相应的毂部件，以将连接器管保持与注射器接触。 优选地，注射器和连接管被包装在预连接状态中，以便客户易于使用。 此外，描述了用于连接到注射器的柔性入口管，用于例如用造影剂填充注射器。 入口管允许从袋或瓶中填充注射器，并且可以保持附接到注射器，使得其形成与患者的连接的至少一部分。 此外，描述了一种便于从最终连接在注射器和患者之间的连接管吹扫空气的装置。 该装置包括从注射器连接到连接管的远端的清洗管。 吹扫管在其远端包括通气盖。 流动抑制剂位于排气盖下面，以与通气帽配合，通过阻止从清洗管的远端排出流体，同时允许排出空气。

    Method of substituting a first fluid delivery device with a second fluid delivery device
    7.
    发明授权
    Method of substituting a first fluid delivery device with a second fluid delivery device 有权
    用第二流体输送装置代替第一流体输送装置的方法

    公开(公告)号：US07540854B2

    公开(公告)日：2009-06-02

    申请号：US10190361

    申请日：2002-07-03

    申请人： Frederick W. Trombley, III ,  Francis J. Sciulli, Jr. ,  David M. Griffiths ,  Arthur E. Uber, III

    发明人： Frederick W. Trombley, III ,  Francis J. Sciulli, Jr. ,  David M. Griffiths ,  Arthur E. Uber, III

    IPC分类号： A61M37/00 ,  A61B6/00

    CPC分类号： A61M5/142 ,  A61M39/08 ,  A61M39/10

    摘要： A method of substituting an MRI incompatible pump for delivering fluid to a patient with an MRI compatible pump, both pumps being microprocessor controlled. The first pump operates upon administration tubing for pumping fluid from a source thereof to the patient. The method includes the steps of: providing the second pump to be substituted for the first pump; providing second tubing having a portion thereof that is operable to function with the second pump; connecting the second tubing to the administration tubing to establish an altered fluid path from the source to the patient, the altered path including portions of both the administration and second tubing; placing the second pump for operation upon the second tubing to enable the second pump to pump the fluid through the altered path according to programming thereof; and disconnecting the first pump from the administration tubing before bringing the patient into the MRI environment.

    摘要翻译： 用MRI兼容的泵代替MRI不相容的泵将流体输送到具有MRI兼容泵的患者的方法，两个泵都由微处理器控制。 第一泵在管道管上操作，以将流体从源的泵送到患者。 该方法包括以下步骤：提供要替代第一泵的第二泵; 提供第二管道，其具有可与第二泵一起起作用的部分; 将所述第二管道连接到所述管道管，以建立从所述源到所述患者的改变的流体路径，所述改变的路径包括所述施用和所述第二管道的两部分; 将第二泵放置在第二管上以使第二泵根据其编程使泵流体通过改变的路径; 并在将患者进入MRI环境之前将第一个泵与管线管连接起来。

    Syringes and injector systems with collapsible cartridges
    8.
    发明授权
    Syringes and injector systems with collapsible cartridges 有权
    具有可折叠墨盒的注射器和注射器系统

    公开(公告)号：US06620134B1

    公开(公告)日：2003-09-16

    申请号：US09831125

    申请日：2001-05-04

    申请人： Frederick W. Trombley, III ,  Arthur E. Uber, III

    发明人： Frederick W. Trombley, III ,  Arthur E. Uber, III

    IPC分类号： A61M3700

    CPC分类号： A61M5/2425 ,  A61M5/1452 ,  A61M5/14546 ,  A61M5/14566

    摘要： A syringe system (20) includes an elongated shell (30), a pressure member (80) slidable disposed within the elongated shell (30), and a collapsible cartridge (100). The Collapsible cartridge (100) is inserted within the elongated shell (30), and collapses as the pressure member (30) is advanced within the elongated body (30) to pressurize fluid within the collapsible cartridge (100). The collapsible cartridge (100) preferably further includes a passage (130) through which the fluid passes when pressurized by the pressure member (80).

    摘要翻译： 注射器系统（20）包括细长壳（30），可滑动地设置在细长壳（30）内的压力构件（80）和可折叠筒（100）。 可折叠筒（100）插入细长壳（30）内，并且当压力构件（30）在细长主体（30）内前进并且压缩可折叠筒（100）内的流体时，塌缩。 可折叠筒（100）优选地还包括通道（130），当压力构件（80）加压时流体通过该通道。