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    System for washing and processing of cells for delivery thereof to tissue
    4.
    发明授权
    System for washing and processing of cells for delivery thereof to tissue 失效
    用于洗涤和处理细胞以将其递送至组织的系统

    公开(公告)号：US07713232B2

    公开(公告)日：2010-05-11

    申请号：US11460635

    申请日：2006-07-28

    申请人： Arthur E. Uber, III ,  Frederick W. Trombley, III ,  Kevin P. Cowan ,  Mark Trocki

    发明人： Arthur E. Uber, III ,  Frederick W. Trombley, III ,  Kevin P. Cowan ,  Mark Trocki

    IPC分类号： G01N35/10

    CPC分类号： A61J1/1443 ,  A61J1/1456 ,  A61J1/1475 ,  A61M5/142 ,  A61M5/1723 ,  A61M5/3145 ,  A61M31/005 ,  B01L3/502 ,  B01L2300/044 ,  B01L2300/0681 ,  G06F19/3468

    摘要： A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

    摘要翻译： 用于将注射器注射到患者体内的系统包括用于保持注射器的第一可加压容器; 与所述第一可加压容器流体连接的患者接口，所述患者接口适于将所述注射器通入患者的组织; 动力注射器，其与所述第一可加压容器可操作地连接以对所述注射器加压; 与动力注射器操作连接的控制器系统; 以及适于与病人界面操作连接的立体定向定位框架，以协助控制患者界面的定位。 用于处理细胞（和/或其它注射组分）的系统​​包括适于可滑动地定位在容器内的容器和柱塞。 该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。 柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于经由入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物 港口。

    Systems and methods of delivering a dilated slurry to a patient
    8.
    发明授权
    Systems and methods of delivering a dilated slurry to a patient 有权
    将扩张的浆液递送到患者的系统和方法

    公开(公告)号：US08382704B2

    公开(公告)日：2013-02-26

    申请号：US11960968

    申请日：2007-12-20

    申请人： Arthur E. Uber, III ,  David M. Griffiths ,  David M. Reilly ,  Alan D. Hirschman ,  Kevin P. Cowan ,  Mark Trocki

    发明人： Arthur E. Uber, III ,  David M. Griffiths ,  David M. Reilly ,  Alan D. Hirschman ,  Kevin P. Cowan ,  Mark Trocki

    IPC分类号： A61M37/00

    CPC分类号： A61M5/1407 ,  A61M5/14216 ,  A61M5/14236 ,  A61M5/1723 ,  A61M2202/09 ,  B01F7/00258 ,  B01F7/00566 ,  B01F7/00908 ,  B01F7/086 ,  B01F9/103 ,  B01F11/0071 ,  B01F11/0074 ,  B01F11/0082 ,  B01F11/025 ,  B01F13/002 ,  B01F13/0023 ,  B01F13/0818 ,  G06F19/00

    摘要： A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movement of the dilated cell-slurry.

    摘要翻译： 用于将细胞浆料递送到患者的系统可以包括流体，在流体中不可溶或不混溶的细胞，从而形成细胞浆液，适于容纳细胞浆液和细胞上清液的注射器 - 注射器限定具有出口的第一端，细胞浆料通过该出口传送到患者，与注射器相关联的适于用一部分上清液进行细胞浆液的扩张的流化系统，形成 扩张的细胞浆液，将扩张的细胞浆液从流化系统转移到注射器，同时保持至少一部分上清液，细胞浆液和上清液从流化系统转移到注射器，加压机构 适于产生压力以使得包含在注射器内的扩张的细胞浆液流动以传递给患者，以及与控制流化系统连通并适于控制流化系统的控制单元 扩散细胞浆的机制和运动。

    Syringes, syringe tubing and fluid transfer systems
    10.
    发明授权
    Syringes, syringe tubing and fluid transfer systems 有权
    注射器，注射器管和流体传输系统

    公开(公告)号：US06733477B2

    公开(公告)日：2004-05-11

    申请号：US09731108

    申请日：2000-12-06

    申请人： Kevin P. Cowan ,  Frederick W. Trombley, III ,  Mark Trocki ,  David M. Reilly

    发明人： Kevin P. Cowan ,  Frederick W. Trombley, III ,  Mark Trocki ,  David M. Reilly

    IPC分类号： A61M500

    CPC分类号： A61M5/14546 ,  A61M5/385 ,  A61M2005/1403

    摘要： A syringe includes a body and a plunger disposed therein. The body includes a nozzle formed therein and at least one hub member connected thereto or integrally formed thereon for holding an end of a connector tube. The connector tube includes two ends, each end preferably being connected to a respective hub member to retain the connector tube in contact with the syringe. Preferably, the syringe and the connector tube are packaged in a pre-connected condition for ease of use by the customer. Furthermore, flexible inlet tubing for connection to a syringe for filling the syringe with contrast media, for example, is described. The inlet tubing permits filling of the syringe from either a bag or a bottle and may remain attached to the syringe so that it forms at least a part of the connection to the patient. In addition, an apparatus for facilitating the purge of air from a connector tube that will ultimately be connected between a syringe and a patient is described. The apparatus includes a purging tube connected to the distal end of the connector tubing from the syringe. The purging tube includes a venting cap at its distal end. A flow inhibitor is positioned under the venting cap to cooperate with the venting cap by discouraging the discharge of fluid from the distal end of the purging tube while permitting the discharge of air therefrom.

    摘要翻译： 注射器包括主体和设置在其中的柱塞。 主体包括形成在其中的喷嘴和与其连接或一体地形成在其上的至少一个毂构件，用于保持连接器管的端部。 连接器管包括两个端部，每个端部优选地连接到相应的毂部件，以将连接器管保持与注射器接触。 优选地，注射器和连接管被包装在预连接状态中，以便客户易于使用。 此外，描述了用于连接到注射器的柔性入口管，用于例如用造影剂填充注射器。 入口管允许从袋或瓶中填充注射器，并且可以保持附接到注射器，使得其形成与患者的连接的至少一部分。 此外，描述了一种便于从最终连接在注射器和患者之间的连接管吹扫空气的装置。 该装置包括从注射器连接到连接管的远端的清洗管。 吹扫管在其远端包括通气盖。 流动抑制剂位于排气盖下面，以与通气帽配合，通过阻止从清洗管的远端排出流体，同时允许排出空气。