摘要:
The present invention relates to aryl pyrazoles, and pharmaceutically acceptable salts thereof. The aryl pyrazoles of the present invention are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the aryl pyrazoles of the present invention, methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要:
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要:
The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要:
The present invention encompasses compounds of the formula (I): wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
摘要:
A transmission system allowing a window to be opened in three directions includes a door hinge assembly, a guide wheel assembly, a lock assembly, a handle, a first transmission lever, a second transmission lever, an angle converter, a first gear tooth combination, a second gear tooth combination a and a second gear tooth combination b. The angle converter is connected at a position of the first transmission lever and a position of the second transmission lever located at corners of a window sash. The first gear tooth combination is arranged in the handle. The second gear tooth combination a and the second gear tooth combination b are connected to the top and the bottom of the window sash respectively. The lock assemblies are symmetrically provided at two sides of the second gear tooth combination a and the second gear tooth combination b.
摘要:
A hemostasis and suturing conjoined dual-clamp capable of passing through a channel of a digestive endoscope and an operation method, the dual-clamp including a handle, a clamping assembly and a driving assembly. The clamping assembly includes a clamping holder and two clamping portions, and the driving assembly is detachably connected to the clamping assembly. A hemostasis and suturing conjoined dual-clamp capable of passing through a channel of a digestive endoscope and an operation method, two clamping arms of the dual-clamp are able to individually open, clamp and close, have a function of double-sided clamping and closing a large defective wound, and are able to be conveniently separated from the driving assembly, overcoming the defects that conventional hemostatic clamps can only perform one-sided clamping, thereby it is difficult to treat defective wounds that are large or in difficult operating sites.
摘要:
An image signal processing (ISP) system is provided. The system includes a neural network trained by inputting a set of raw data images and a correlating set of desired quality output images; the neural network including an input for receiving input image data and providing processed output; wherein the processed output includes input image data that has been adjusted for at least one image quality attribute. A method and an imaging device are disclosed.
摘要:
A method for displaying contacts in an instant messenger. The method includes displaying information of the contacts in the form of cards in a container; responding to an event that a card is selected; and highlighting the selected card on a surface layer of the container. An instant messaging client is also provided.
摘要:
Three-arm clamp includes: clamping assembly and releasing member connected to each other, clamping assembly includes fixed arm, and two movable arms respectively rotatably connected to fixed arm by hinge pin; the proximal end of each movable arm is provided with first sliding slot, and sliding pin is slidably arranged in first sliding slot; the proximal end of fixed arm is provided with inner cavity, and releasing member is inserted into inner cavity and connected to sliding pin; the proximal end of each movable arm is provided with elastic sheet; movable arms and fixed arm are closed by clamping, and elastic sheets are folded in inner cavity, in radial direction of fixed arm, from connecting end to free end and abut against releasing member; and releasing member is separated from movable arms, and the free end of each elastic sheet elastically abuts against inner wall of inner cavity.
摘要:
A method for enhancing at least one image within a series of images is provided. The method includes: selecting the series of images; upscaling each image within the series of images; selecting a reference image among the series of images; performing image registration to align series of images with the reference image; evaluating the series of aligned images for a subset of pixel locations that exhibit high cross-frame variation; performing learning processing to substantially reduce noise and exclude motion biases at the subset of pixel locations; performing pixel fusion from the series of aligned and processed images to produce the super-resolution reference image. A computer program product and an imaging system are disclosed.